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This compounded formulation of Benztropine Mesylate 1 mg, Haloperidol 1 mg, Lorazepam 1 mg, and Metoclopramide HCl 40 mg is prepared as a suppository, a solid dosage form designed for insertion into a body cavity, typically the rectum, where it dissolves or melts to release medication for local or systemic absorption.
This combination is utilized in the management of conditions such as severe nausea and vomiting, agitation, and acute episodes of psychosis. It may also be used to address symptoms associated with Parkinson's disease and to provide relief from anxiety.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This compounded suppository formulation combines Benztropine Mesylate 1 mg, Haloperidol 1 mg, Lorazepam 1 mg, and Metoclopramide HCl 40 mg in a solid dosage form intended for rectal administration. When inserted into the rectum, the suppository dissolves or melts, allowing the active ingredients to be absorbed into the systemic circulation for both local and systemic therapeutic effects.
This specialized formulation is designed to address complex clinical scenarios where patients experience severe nausea, vomiting, agitation, psychosis, and extrapyramidal symptoms, and where oral medication administration is not feasible. The rectal route ensures that medications are delivered effectively when gastrointestinal disturbances or swallowing difficulties impede oral intake.
Metoclopramide HCl at a high dose of 40 mg acts as a prokinetic agent and antiemetic. It enhances gastrointestinal motility and accelerates gastric emptying by antagonizing dopamine receptors in the gastrointestinal tract. Additionally, it acts on the central nervous system to inhibit the chemoreceptor trigger zone, thereby reducing nausea and vomiting. This makes it particularly beneficial for
This compounded formulation of Benztropine Mesylate, Haloperidol, Lorazepam, and Metoclopramide HCl in suppository form is designed to provide a combination of therapeutic effects for the management of various conditions, potentially including movement disorders, psychiatric conditions, anxiety, and gastrointestinal issues such as nausea and vomiting. However, due to the complexity of this combination, it is crucial to consider potential drug interactions that may affect the safety and efficacy of the treatment.
Benztropine Mesylate is an anticholinergic agent that can interact with other medications possessing anticholinergic properties, potentially leading to additive effects such as dry mouth, constipation, urinary retention, and confusion. Caution is advised when used concurrently with other anticholinergics or medications that may exacerbate these side effects.
Haloperidol, an antipsychotic, can interact with medications that prolong the QT interval, increasing the risk of serious cardiac arrhythmias. It is important to avoid concurrent use with other QT-prolonging drugs, such as certain antiarrhythmics, antibiotics, and antidepressants. Additionally, haloperidol may enhance the CNS depressant effects of other medications, including benzodiazepines and alcohol, leading to increased sedation and respiratory depression.
Lorazepam, a benzodiazepine, can potentiate the effects of other CNS depressants, including alcohol, opioids, and other sedatives, increasing the risk of profound sedation, respiratory depression, and hypotension. Patients should be advised to avoid alcohol and use caution when taking other CNS depressants. Lorazepam may also interact with medications that affect hepatic enzymes, altering its metabolism and potentially leading to increased or decreased drug levels.
Metoclopramide HCl, a prokinetic agent, can interact with medications that affect dopamine pathways, such as antipsychotics, potentially leading to an increased risk of extrapyramidal symptoms or neuroleptic malignant syndrome. It may also affect the absorption of other orally administered drugs due to its effects on gastrointestinal motility. Caution is advised when used with medications that have a narrow therapeutic index or require precise dosing.
Given the potential for significant drug interactions, it is essential for prescribers to thoroughly review a patient's medication history and consider any potential interactions before initiating this compounded formulation. Patients should be closely monitored for any adverse effects or changes in therapeutic response. If you have any questions or require further information, please reach out to us at Bayview Pharmacy.
This compounded formulation of Benztropine Mesylate, Haloperidol, Lorazepam, and Metoclopramide HCl in suppository form is designed to provide a multifaceted approach to managing symptoms associated with various neurological and gastrointestinal conditions. Each active ingredient plays a specific role in addressing different aspects of these conditions, and the suppository form allows for both local and systemic absorption, which can be particularly beneficial for patients who have difficulty swallowing or require rapid onset of action.
Benztropine Mesylate is an anticholinergic agent that works by blocking certain neurotransmitters in the brain, specifically acetylcholine. This action helps to restore the balance between acetylcholine and dopamine, which is often disrupted in conditions like Parkinson's disease and drug-induced extrapyramidal symptoms. By reducing the activity of acetylcholine, Benztropine Mesylate can help alleviate symptoms such as tremors, muscle stiffness, and involuntary movements.
Haloperidol is a typical antipsychotic that primarily works by blocking dopamine receptors in the brain. This action is beneficial in treating psychiatric disorders such as schizophrenia and acute psychosis, as well as managing severe behavioral problems. By reducing the effects of excess dopamine, Haloperidol helps to stabilize mood, reduce hallucinations, and improve overall mental function.
Lorazepam is a benzodiazepine that enhances the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Its sedative properties also make it useful in managing symptoms of withdrawal and providing preoperative sedation.
Metoclopramide HCl is a prokinetic agent that works by enhancing the motility of the upper gastrointestinal tract without increasing gastric secretions. By promoting gastric emptying and increasing the tone of the lower esophageal sphincter, Metoclopramide helps alleviate symptoms associated with delayed gastric emptying and reflux.
The suppository form of this formulation allows for direct absorption through the rectal mucosa, bypassing the gastrointestinal tract and potentially reducing the risk of gastrointestinal side effects. This route of administration can be advantageous for patients experiencing nausea or vomiting, as it ensures that the medication is absorbed even if oral administration is not feasible. Additionally, the rectal route can provide a more rapid onset of action compared to oral administration, which can be crucial in managing acute symptoms.
For both patients and prescribers, it is important to understand the synergistic effects of these medications when used in combination. The formulation is tailored to address multiple symptoms simultaneously, providing a comprehensive treatment approach. However, it is essential to monitor for potential interactions and side effects, as the combination of these medications can increase the risk of sedation, anticholinergic effects, and extrapyramidal symptoms. Patients should be advised to report any unusual symptoms or side effects to their healthcare provider promptly.
If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries you may have.
This compounded formulation is designed to provide a combination of medications that may be used to manage symptoms such as nausea, vomiting, anxiety, and muscle spasms. Each component has a specific role, and together they can offer a comprehensive approach to symptom management.
These suppositories should be inserted into the rectum or vagina, depending on your healthcare provider's instructions. They are designed to dissolve or melt, allowing the medication to be absorbed locally or systemically. Follow the specific instructions provided by your healthcare provider or pharmacist.
Potential side effects may include drowsiness, dizziness, dry mouth, constipation, blurred vision, and urinary retention. Each component of the formulation may have its own side effects, so it's important to discuss any concerns with your healthcare provider.
You should consult your healthcare provider before using this formulation if you are pregnant or breastfeeding. They will assess the potential risks and benefits based on your specific situation.
Store the suppositories in a cool, dry place, away from direct sunlight and heat.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Before using this formulation with other medications, consult your healthcare provider or pharmacist. They will help you understand any potential interactions and adjust your treatment plan accordingly.
The time it takes for the suppository to dissolve and take effect can vary depending on individual factors and the specific formulation. Generally, it may take about 15 to 60 minutes for the medication to be absorbed and start working.
Contraindications may include hypersensitivity to any of the components, certain medical conditions, or interactions with other medications. It's important to discuss your medical history with your healthcare provider before using this formulation.
If you experience severe side effects or signs of an allergic reaction, such as difficulty breathing, swelling, or rash, seek immediate medical attention. Contact your healthcare provider for guidance on how to proceed with your treatment.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
