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This formulation consists of Caffeine 150 mg, Indomethacin 50 mg, and Prochlorperazine Maleate 8 mg in suppository form. It is a solid dosage form designed for insertion into a body cavity, typically the rectum, where it dissolves or melts to release medication for local or systemic absorption.
This combination is used to treat migraine headaches and associated symptoms such as nausea and inflammation. The caffeine acts as a vasoconstrictor to alleviate headache pain, indomethacin provides anti-inflammatory effects, and prochlorperazine maleate helps control nausea and vomiting.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This compounded suppository combines caffeine 150 mg, indomethacin 50 mg, and prochlorperazine maleate 8 mg in a solid dosage form designed for rectal administration. The suppository dissolves or melts upon insertion, allowing the medications to be absorbed either locally or systemically.
This formulation is primarily used in the management of severe migraine headaches, especially in patients who experience nausea and vomiting that prevent oral medication intake. The combination of these three medications works synergistically to alleviate migraine symptoms effectively.
Caffeine acts as a central nervous system stimulant and vasoconstrictor. It helps constrict dilated blood vessels in the brain, which can relieve headache pain. Additionally, caffeine enhances the absorption and effectiveness of analgesics, making it a valuable component in migraine treatment.
Indomethacin is a potent nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever. By inhibiting the synthesis of prostaglandins, it helps alleviate the inflammatory processes associated with migraines, providing significant pain relief.
Prochlorperazine
This formulation of Caffeine 150 mg, Indomethacin 50 mg, and Prochlorperazine Maleate 8 mg in suppository form is designed to provide therapeutic benefits through both local and systemic absorption. Caffeine is a central nervous system stimulant that can enhance alertness and reduce fatigue. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain. Prochlorperazine Maleate is an antipsychotic and antiemetic agent used to control severe nausea and vomiting. This combination may be used to treat conditions such as migraine headaches, where pain relief, anti-inflammatory effects, and antiemetic properties are beneficial.
When using this formulation, it is crucial to consider potential drug interactions that may affect the safety and efficacy of the treatment. Caffeine can interact with various medications, including other stimulants, which may increase the risk of side effects such as increased heart rate, anxiety, and insomnia. It can also affect the metabolism of certain drugs by influencing liver enzymes, potentially altering their effectiveness or increasing their toxicity.
Indomethacin, as an NSAID, may interact with anticoagulants like warfarin, increasing the risk of bleeding. It can also reduce the effectiveness of antihypertensive medications, such as ACE inhibitors and beta-blockers, and may increase the risk of kidney damage when used with diuretics. Additionally, concurrent use with other NSAIDs or corticosteroids can heighten the risk of gastrointestinal bleeding and ulceration.
Prochlorperazine Maleate can interact with medications that affect the central nervous system, such as sedatives, tranquilizers, and alcohol, potentially leading to enhanced sedative effects. It may also interact with anticholinergic drugs, increasing the risk of side effects like dry mouth, constipation, and urinary retention. Furthermore, prochlorperazine can affect the action of medications that prolong the QT interval, increasing the risk of serious cardiac arrhythmias.
Patients and prescribers should be aware of these potential interactions and monitor for any adverse effects. It is essential to review the patient's current medication regimen, including over-the-counter drugs and supplements, to identify any possible interactions. Adjustments to dosages or alternative therapies may be necessary to ensure appropriate treatment. If you have any questions or concerns about this formulation or its interactions, please reach out to us at Bayview Pharmacy for further assistance.
This compounded formulation of Caffeine 150 mg, Indomethacin 50 mg, and Prochlorperazine Maleate 8 mg in suppository form is designed to provide a multifaceted approach to managing certain disease states, potentially including migraine headaches, severe nausea, and inflammation-related conditions. The suppository is a solid dosage form intended for insertion into a body cavity, typically the rectum, where it dissolves or melts to release the active ingredients for local or systemic absorption. This route of administration can be particularly beneficial for patients who are unable to take medications orally due to nausea, vomiting, or other gastrointestinal issues.
Caffeine, a central nervous system stimulant, is included in this formulation to enhance the absorption and efficacy of other medications, particularly analgesics like indomethacin. Caffeine can also contribute to vasoconstriction, which may help alleviate headache symptoms by reducing blood flow in dilated blood vessels, a common occurrence in migraine attacks. By improving the absorption of indomethacin, caffeine can enhance the overall therapeutic effect of the suppository.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that mediate inflammation and pain. By reducing the levels of these chemicals, indomethacin helps to alleviate pain and inflammation associated with various conditions, including migraines and other inflammatory disorders. The rectal administration of indomethacin can provide a rapid onset of action, which is particularly useful in acute settings where quick relief is desired.
Prochlorperazine Maleate is an antiemetic and antipsychotic medication that belongs to the class of drugs known as phenothiazines. It works by blocking dopamine receptors in the brain, which helps to control severe nausea and vomiting. This action is particularly beneficial for patients experiencing nausea as a result of migraines or other medical treatments. By including prochlorperazine in the suppository, patients can achieve relief from nausea and vomiting, which can be a significant barrier to effective oral medication administration.
The combination of these three active ingredients in a suppository form allows for a comprehensive approach to managing symptoms associated with migraines, severe nausea, and inflammation. This formulation is particularly useful in acute situations where rapid symptom relief is necessary. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.
This compounded formulation is typically used to manage symptoms such as pain, inflammation, and nausea. The combination of these medications can provide relief for conditions like migraines or severe headaches.
Insert the suppository into the rectum or vagina, depending on your healthcare provider's instructions. The suppository will dissolve or melt, allowing the medication to be absorbed locally or systemically.
The frequency of use should be determined by your healthcare provider. It is important to follow their instructions to avoid potential side effects or overdose.
If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Possible side effects may include irritation at the site of insertion, dizziness, or gastrointestinal discomfort. If you experience severe side effects or an allergic reaction, seek medical attention immediately.
You should consult your healthcare provider before using this medication if you are pregnant or breastfeeding, as the safety of these suppositories in such conditions has not been fully established.
Store the suppositories in a cool, dry place away from direct sunlight. Keep them out of reach of children and pets. Follow any specific storage instructions provided by your pharmacist.
Before using these suppositories, inform your healthcare provider about any other medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
If you experience severe side effects such as difficulty breathing, swelling, or severe irritation, discontinue use and seek immediate medical attention.
Some leakage may occur after insertion as the suppository dissolves. To minimize discomfort, you may want to lie down for a few minutes after insertion and use a sanitary pad if necessary.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
