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This topical gel formulation combines Caffeine 25 mg/g, Meloxicam 7.5 mg/g, and Promethazine 12.5 mg/g, designed for targeted treatment of pain, inflammation, and nausea associated with conditions such as arthritis, migraines, and motion sickness.
A semisolid formulation dispensed through a pump mechanism, facilitating easy and precise application on the skin for targeted treatment or absorption of active ingredients in a gel-like consistency.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This topical gel formulation combines caffeine, meloxicam, and promethazine, each with distinct pharmacological properties that may interact with other medications. Caffeine, a central nervous system stimulant, can potentially interact with other stimulants, leading to increased heart rate and blood pressure. Patients using other medications containing caffeine or those with cardiovascular conditions should use this formulation cautiously. Additionally, caffeine may enhance the effects of certain medications, such as theophylline, and may interfere with the metabolism of drugs metabolized by the CYP1A2 enzyme, such as clozapine and fluvoxamine.
Meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), can interact with other NSAIDs, increasing the risk of gastrointestinal bleeding and ulceration. It may also interact with anticoagulants like warfarin, enhancing their effects and increasing bleeding risk. Patients on antihypertensive medications should be aware that meloxicam may reduce the efficacy of these drugs, potentially leading to elevated blood pressure. Additionally, meloxicam can interact with lithium, increasing lithium levels and the risk of toxicity. Caution is advised when using this formulation in patients with renal impairment, as NSAIDs can further compromise kidney function.
Promethazine, an antihistamine with sedative properties, can interact with other central nervous system depressants, such as benzodiazepines, opioids, and alcohol, leading to enhanced sedation and respiratory depression. It may also interact with monoamine oxidase inhibitors (MAOIs), potentially causing severe side effects such as hypertensive crisis. Promethazine can affect the metabolism of certain medications by inhibiting the CYP2D6 enzyme, which may alter the effectiveness of drugs like codeine and metoprolol. Patients with a history of seizures should use this formulation cautiously, as promethazine may lower the seizure threshold.
For both patients and prescribers, it is crucial to consider these potential drug interactions when using this topical gel formulation. A thorough review of the patient's current medication regimen is recommended to identify any possible interactions. If you have any questions or concerns about using this formulation, please reach out to us at Bayview Pharmacy for further guidance and support.
The Caffeine 25 mg/g, Meloxicam 7.5 mg/g, and Promethazine 12.5 mg/g Topical Gel is a compounded formulation designed to deliver a synergistic combination of active ingredients directly to the site of application. This semisolid gel is dispensed through a pump mechanism, ensuring easy and precise application on the skin, which enhances the targeted treatment and absorption of the active ingredients. The gel-like consistency allows for smooth application and rapid absorption, minimizing systemic exposure and potential side effects associated with oral administration.
Caffeine, a methylxanthine, is included in this formulation for its vasoconstrictive and anti-inflammatory properties. When applied topically, caffeine can help reduce inflammation and swelling by constricting blood vessels, which may be beneficial in conditions characterized by localized inflammation and pain. Additionally, caffeine is known to enhance the penetration of other active ingredients through the skin, potentially increasing the efficacy of the formulation.
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their production, meloxicam helps alleviate pain and inflammation. The topical application of meloxicam allows for direct action at the site of discomfort, providing relief from symptoms associated with musculoskeletal conditions, arthritis, and other inflammatory disorders.
Promethazine is an antihistamine with additional antiemetic and sedative properties. In this topical formulation, promethazine primarily acts to reduce histamine-mediated symptoms such as itching and irritation, which can accompany inflammatory skin conditions. Its inclusion in the gel may also provide a soothing effect, enhancing patient comfort during treatment.
This combination of caffeine, meloxicam, and promethazine in a topical gel is particularly useful for patients who require localized treatment of pain, inflammation, and irritation without the systemic side effects associated with oral medications. The formulation is ideal for individuals with conditions such as arthritis, localized muscle pain, or inflammatory skin disorders. By applying the gel directly to the affected area, patients can achieve targeted relief, improving their quality of life and daily functioning.
For prescribers, this compounded formulation offers a customizable approach to patient care, allowing for adjustments in the concentration of active ingredients based on individual patient needs and response to treatment. The use of a pump mechanism ensures consistent dosing and ease of use, promoting adherence to the treatment regimen.
If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.
This topical gel is designed for targeted treatment or absorption of active ingredients through the skin. Caffeine may help with circulation, Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) for pain relief, and Promethazine is an antihistamine that can help with allergic reactions or skin irritation.
The gel should be dispensed through the pump mechanism and applied directly to the affected area of the skin. Use a small amount and gently rub it in until fully absorbed. Follow your healthcare provider's instructions for specific application guidelines.
The frequency of application should be determined by your healthcare provider. Typically, it may be applied once or twice daily, but always follow the specific instructions provided with your prescription.
Possible side effects may include skin irritation, redness, or itching at the application site. If you experience severe reactions or symptoms persist, contact your healthcare provider immediately.
No, you should not apply the gel to broken, damaged, or irritated skin. It is intended for use on intact skin only. Consult your healthcare provider if you have concerns about where to apply the gel.
Consult your healthcare provider before using this gel if you are pregnant or breastfeeding. They will assess the potential risks and benefits based on your specific situation.
Before using other topical products in conjunction with this gel, consult your healthcare provider to avoid potential interactions or reduced effectiveness of the treatment.
Store the gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not freeze the gel.
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not apply extra gel to make up for a missed dose.
In case of an overdose, seek immediate medical attention or contact a poison control center. Overdose symptoms may include severe skin irritation or other adverse reactions.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
