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The Fluconazole 4%/Ibuprofen 4% Nail Lacquer is a specialized liquid formulation crafted for direct application to the nails. This unique combination of an antifungal agent and a nonsteroidal anti-inflammatory drug (NSAID) is designed to treat nail conditions such as onychomycosis, a fungal infection of the nails, and to alleviate symptoms associated with nail psoriasis, including brittleness and discoloration. The fluconazole component targets the fungal infection, while ibuprofen helps to reduce inflammation and pain. This nail lacquer formulation ensures that the active ingredients are delivered effectively to the site of infection and inflammation, promoting healthy nail regrowth and enhancing the overall appearance of the nails.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Fluconazole 4%/Ibuprofen 4% Nail Lacquer is a specialized liquid formulation created for the topical treatment of various nail conditions, including fungal infections, brittleness, and discoloration. This unique combination of an antifungal agent and a nonsteroidal anti-inflammatory drug (NSAID) is designed to be applied directly to the nails, ensuring that the active ingredients are delivered to the site of infection or damage. Fluconazole, as an antifungal, works by inhibiting the growth of a wide range of fungi by interfering with the synthesis of the fungal cell membrane.
Ibuprofen, on the other hand, is included in the formulation for its anti-inflammatory properties, which can help reduce pain and inflammation associated with fungal infections or other nail traumas. By combining these two agents, the nail lacquer not only addresses the underlying fungal infection but also helps alleviate symptoms that can cause discomfort and impact the appearance of the nails. The lacquer is formulated to adhere to the nail surface.
Patients using this nail lacquer should be advised that consistent application as directed by a healthcare provider is crucial for optimal results. The formulation is designed to promote healthy nail growth and improve the overall appearance of the nails over time. Prescribers should consider this treatment option for patients who require both antifungal and anti-inflammatory action in a convenient topical form.
For more detailed information on the Fluconazole 4%/Ibuprofen 4% Nail Lacquer, including usage instructions, contraindications, potential side effects, and any other concerns, patients and prescribers are encouraged to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide expert guidance and support to ensure appropriate treatment.
The Fluconazole 4%/Ibuprofen 4% Nail Lacquer is a topical formulation designed to treat nail conditions such as fungal infections, brittleness, or discoloration. Fluconazole is an antifungal agent that works by inhibiting the growth of various types of fungi by disrupting the production of the fungal cell membrane. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can help reduce inflammation and pain. When used in a nail lacquer, ibuprofen may help alleviate symptoms such as swelling and tenderness associated with nail infections or trauma.
When considering the drug interactions for this topical formulation, it is important to note that systemic absorption of both fluconazole and ibuprofen through the nail bed is likely to be minimal. However, certain interactions may still be relevant, especially in patients with significant nail damage or those using the medication over large areas of the body.
Fluconazole can interact with a wide range of medications when taken systemically, as it can inhibit the metabolism of drugs that are substrates for the cytochrome P450 enzyme CYP2C9, CYP2C19, and CYP3A4. This could potentially increase the levels of these drugs in the body and lead to increased risk of side effects. Some examples of drugs that could interact with fluconazole include warfarin, certain antidiabetic drugs, and other antifungal drugs. While the risk of systemic interactions is low with topical application, caution should be exercised in patients taking these medications orally.
Ibuprofen, when taken systemically, can interact with antihypertensive medications such as ACE inhibitors, angiotensin receptor blockers, and diuretics, potentially reducing their effectiveness. It can also increase the risk of gastrointestinal bleeding when taken with other NSAIDs, aspirin, or anticoagulant medications such as warfarin. Additionally, ibuprofen may interact with lithium and methotrexate, leading to increased levels of these drugs in the body. Again, the risk of these interactions is reduced with topical application, but patients should be aware of the potential for systemic absorption, especially if they are using other forms of ibuprofen or are on a comprehensive medication regimen.
It is also important to consider the potential for local interactions with other topical products. The use of other topical agents on the nails should be discussed with a healthcare provider to avoid incompatibilities or interference with the therapeutic effects of the nail lacquer.
Patients should be advised to report any signs of adverse reactions or unusual symptoms to their healthcare provider. Prescribers should review the patient's full medication profile for potential interactions before recommending this formulation. If you have any questions or require further information regarding the use of Fluconazole 4%/Ibuprofen 4% Nail Lacquer, please reach out to us at Bayview Pharmacy for assistance.
The Fluconazole 4%/Ibuprofen 4% Nail Lacquer is a specialized topical treatment designed to address various nail conditions, including fungal infections, brittleness, and discoloration. This unique formulation combines the antifungal properties of fluconazole with the anti-inflammatory and pain-relieving effects of ibuprofen, encapsulated in a nail lacquer that adheres to the nail surface for prolonged drug release.
Fluconazole is a well-known antifungal agent that works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. By disrupting the cell membrane, fluconazole effectively weakens the fungal cells, leading to their death and the resolution of the infection. The 4% concentration ensures that a sufficient amount of the active ingredient is delivered to the site of infection, maximizing the antifungal effects while minimizing systemic absorption and potential side effects.
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is incorporated into the nail lacquer to provide symptomatic relief from pain and inflammation that can accompany nail infections or other nail disorders. Ibuprofen works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for pain, fever, and inflammation. By including ibuprofen in the formulation, patients may experience reduced discomfort and swelling associated with their nail condition, promoting a more comfortable healing process.
The nail lacquer dosage form is particularly advantageous for treating nail conditions as it creates a protective film over the nail, allowing for a localized and sustained release of the active ingredients. This targeted approach ensures that the medication remains in contact with the nail for an extended period, enhancing the treatment's efficacy while reducing the potential for systemic side effects. The lacquer also serves to protect the nail from external moisture and contaminants, which can further aid in the healing process.
Patients and prescribers should note that the effectiveness of the Fluconazole 4%/Ibuprofen 4% Nail Lacquer depends on consistent application as directed, usually once or twice daily, to clean, dry nails. The duration of treatment may vary depending on the severity of the condition and the patient's response to therapy. It is important to continue using the nail lacquer for the full course of treatment, even if symptoms improve, to ensure the complete eradication of the infection and prevent recurrence.
For more detailed information on the use of this formulation, or if you have any questions regarding its suitability for a specific patient or condition, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and support to ensure the best possible outcomes for our patients.
Fluconazole 4%/Ibuprofen 4% Nail Lacquer is used to treat fungal infections of the nails while simultaneously alleviating symptoms such as inflammation and pain. It may also help with brittleness and discoloration, promoting healthier nail growth and improving the appearance of the nails.
Fluconazole is an antifungal agent that works by inhibiting the growth of fungal cells, while Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that helps to reduce pain and inflammation. When compounded in a nail lacquer, these medications are delivered directly to the nail, allowing for targeted treatment.
Clean and dry the affected nail(s) before application. Apply the nail lacquer to the entire nail surface and the surrounding skin, according to your healthcare provider's instructions. Ensure the lacquer has dried before putting on socks or shoes.
The frequency of application depends on the advice of your healthcare provider. Generally, it may be applied once daily, but follow your prescriber's specific instructions for the best results.
Yes, you can use this nail lacquer on both fingernails and toenails. However, always consult with your healthcare provider about the appropriate use for your specific condition.
Side effects may include local irritation at the application site, redness, itching, or swelling. If you experience any severe or concerning reactions, contact your healthcare provider promptly.
Results can vary depending on the severity of the nail condition and individual response to treatment. Some improvement in symptoms may be seen relatively quickly, while the clearance of nail fungus often takes several months due to the slow growth rate of nails.
It is generally discouraged to wear traditional nail polish over medical nail lacquers as it may affect the efficacy of the treatment. However, consult with your healthcare provider for their recommendation.
It's usually not necessary to remove the lacquer before each new application if you're applying it once daily. Follow your healthcare provider's instructions, as they may recommend periodic removal and reapplication of the lacquer.
Consult with your healthcare provider for advice regarding use during pregnancy or while breastfeeding, as they can assess the risks and benefits tailored to your situation.
If you miss an application, apply the lacquer as soon as you remember. However, if it's almost time for your next scheduled application, skip the missed dose and proceed as usual. Do not double the application to make up for a missed dose.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
