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The Fluticasone Propionate 1%/Itraconazole 2% Topical Ointment is a semi-solid formulation designed for external application to the skin. This ointment is dispensed in a tube and provides a greasy or oily base, which facilitates the localized delivery of the active ingredients. Fluticasone Propionate is a potent corticosteroid that helps reduce inflammation, itching, and redness associated with various dermatological conditions. Together, this combination is used to treat disease states such as cutaneous fungal infections that are accompanied by inflammatory symptoms or require the concurrent management of inflammation.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Fluticasone Propionate 1%/Itraconazole 2% Topical Ointment is a specialized medication compounded for the treatment of various skin conditions that may benefit from the combined effects of an anti-inflammatory corticosteroid and an antifungal agent. Fluticasone propionate is a potent corticosteroid that works by reducing inflammation, redness, and swelling. Its mechanism of action involves the suppression of the release of inflammatory cytokines and mediators, which are substances that contribute to the inflammatory process.
Itraconazole, on the other hand, is a broad-spectrum antifungal medication that is used to treat fungal infections of the skin. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby causing cell death and resolving the infection. The 2% concentration ensures that the ointment has sufficient antifungal activity to treat localized fungal infections effectively.
The combination of fluticasone propionate and itraconazole in a topical ointment allows for the simultaneous management of inflammation and fungal infections, which can coexist in certain dermatological conditions. This dual-action formulation is particularly useful in cases where a fungal infection has led to an inflammatory skin response or where a pre-existing inflammatory condition has become secondarily infected with fungi.
The ointment is prepared in a semi-solid base that is designed to be applied externally to the skin. The base provides an occlusive layer that helps to maintain skin hydration and enhances the absorption of the active ingredients. The greasy or oily nature of the ointment base also aids in the protection of the affected area, creating a barrier against external irritants and pathogens. This formulation is dispensed in a tube, which allows for easy application and minimizes the risk of contamination.
Patients prescribed this medication should use it as directed by their healthcare provider, typically applying a thin layer to the affected area of the skin. It is important to follow the specific instructions provided, as the potency of fluticasone propionate can lead to side effects if used improperly. Common side effects may include skin irritation, dryness, or changes in skin pigmentation. Long-term use of topical corticosteroids, especially over large areas of the body, should be monitored due to the potential for systemic absorption and associated risks.
Prescribers opting to use this formulation should consider the patient's medical history, the presence of any contraindications, and the potential for interactions with other medications. It is also essential to educate patients on the correct use of the ointment, the importance of adhering to the treatment regimen, and the need to report any adverse effects or lack of improvement in their condition.
At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to the specific needs of our patients. If you have any questions or require further information about the Fluticasone Propionate 1%/Itraconazole 2% Topical Ointment, please do not hesitate to reach out to us.
The combination of Fluticasone Propionate and Itraconazole in a topical ointment is designed to provide both anti-inflammatory and antifungal effects. Fluticasone Propionate is a corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. Itraconazole is an antifungal agent that inhibits the synthesis of ergosterol, a key component of fungal cell membranes, thereby treating and preventing fungal infections of the skin.
When using this combination ointment, it is important to consider potential drug interactions. Fluticasone Propionate, being a corticosteroid, can interact with other medications that suppress the immune system, potentially increasing the risk of infection. Patients should inform their healthcare provider of any other immunosuppressive drugs they are taking, including oral corticosteroids or biologics. Additionally, the systemic absorption of Fluticasone Propionate can be increased when applied to large areas of the skin, under occlusive dressings, or when the skin barrier is disrupted. This could potentially increase the risk of systemic corticosteroid side effects, such as adrenal suppression or Cushing's syndrome, especially if used concurrently with other corticosteroids.
Itraconazole's interactions are more extensive due to its metabolism through the cytochrome P450 enzyme system, particularly CYP3A4. Medications that are also metabolized by this enzyme can lead to increased levels of itraconazole or the concomitant medication, potentially leading to adverse effects or reduced efficacy. Examples include certain antivirals, calcium channel blockers, and statins. Conversely, drugs that induce CYP3A4, such as rifampin and phenytoin, can decrease the effectiveness of itraconazole. Additionally, itraconazole can enhance the effects of anticoagulants like warfarin, necessitating closer monitoring of prothrombin time or INR. Patients should also avoid the consumption of certain acid-reducing medications, such as proton pump inhibitors or H2 antagonists, as they can decrease the absorption of itraconazole from the gastrointestinal tract when taken orally, although this is less of a concern with topical administration.
It is also important to note that while the primary route of administration for this ointment is topical, and systemic absorption is expected to be minimal, the potential for systemic side effects and interactions still exists, especially with prolonged use, application over large surface areas, or in patients with compromised skin integrity. Patients should be advised to use the ointment as directed, and not to apply it more frequently or over a larger area than prescribed. They should also avoid covering the treated area with occlusive dressings unless directed by a healthcare provider.
Patients should be counseled to report any signs of adverse reactions, such as skin irritation, worsening of the skin condition, or signs of systemic corticosteroid effects like unusual weight gain, vision problems, or fatigue. Healthcare providers should review the patient's medication list for potential interactions and monitor for adverse effects. If you have any questions or require further information regarding the use of Fluticasone Propionate/Itraconazole Topical Ointment, please reach out to us at Bayview Pharmacy for assistance.
The Fluticasone Propionate 1%/Itraconazole 2% Topical Ointment is a specialized medication compounded at Bayview Pharmacy, designed to treat a variety of skin conditions that may benefit from the combined effects of an anti-inflammatory corticosteroid and an antifungal agent. This semi-solid formulation is dispensed in a tube and is intended for external application to the skin. The ointment base provides a greasy or oily consistency, which not only facilitates the application but also aids in the delivery and sustained release of the active ingredients to the affected area.
Fluticasone Propionate is a potent synthetic corticosteroid that exhibits anti-inflammatory, antipruritic (anti-itch), and vasoconstrictive properties. When applied topically, Fluticasone Propionate works by reducing the release of inflammatory substances and immune responses that cause skin inflammation and irritation. By diminishing inflammation and swelling, it helps to alleviate the discomfort associated with these conditions.
Itraconazole, on the other hand, is a broad-spectrum antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting the cell membrane formation, Itraconazole effectively weakens the fungal cells, leading to their death and resolving the infection. This makes the ointment particularly useful in treating skin infections caused by a wide range of fungi, including those that are resistant to other antifungal medications.
The combination of Fluticasone Propionate and Itraconazole in a single topical ointment provides a synergistic effect that not only addresses the symptoms of inflammation and itching but also targets the underlying fungal infection. This dual-action approach ensures that both the cause and the symptoms of the skin condition are treated.
It is important for patients and prescribers to understand that this compounded formulation should be used as directed by a healthcare professional. The ointment should be applied to the affected area in a thin layer, usually once or twice daily, or as prescribed. The duration of treatment will depend on the severity and type of the skin condition being treated. As with any medication, potential side effects may occur, and it is essential to monitor the treatment area for any signs of adverse reactions or worsening of the condition.
For any questions or concerns regarding the use of Fluticasone Propionate 1%/Itraconazole 2% Topical Ointment, or to discuss the suitability of this formulation for a specific patient, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and support to ensure the safe and appropriate use of our compounded medications.
Fluticasone Propionate/Itraconazole Topical Ointment is a compounded medication used for treating skin conditions that may involve inflammation and infections.
After thoroughly washing and drying the affected area, a thin layer of the ointment should be gently applied usually twice daily, or as directed by your healthcare provider. Hands should be washed immediately after applying the ointment unless the treatment is for hands.
Potential side effects may include local skin reactions such as burning, itching, dryness, or irritation. More serious side effects can include thinning of the skin, changes in skin color, or hormonal side effects like weight gain or fatigue. If you experience any severe reactions, contact your healthcare provider immediately.
Before using this compounded ointment, discuss with your healthcare provider about any other topical or systemic medications you are taking to avoid potential interactions. Your provider will assess whether it's safe to use in combination with other drugs.
This medication should be used with caution in children or the elderly, and only under the direction of a healthcare professional who can monitor for potential adverse effects or hormonal disruptions.
The ointment should be stored at room temperature, away from direct sunlight and heat. Keep the tube tightly closed when not in use, and make sure to keep it out of reach of children and pets.
This medication is typically meant for intact skin. Avoid using it on open, bleeding, or infected wounds without consulting your healthcare provider first.
If you miss a dose, apply the ointment as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double doses to catch up.
The duration of treatment varies depending on the severity and type of skin condition. Always follow the treatment duration as prescribed by your healthcare provider, even if symptoms appear to improve.
It is best to consult your healthcare provider before applying other skin care products or cosmetics over the ointment. In general, you should allow the medication to fully absorb before applying anything else to the skin to avoid diluting the ointment or causing irritation.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
