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The Indomethacin 100 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon administration, it dissolves or melts, facilitating the release of the active ingredient, indomethacin, for both local and systemic absorption. This formulation is primarily used to treat inflammatory diseases such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. Additionally, indomethacin suppositories may be used to treat acute gouty arthritis and for the relief of moderate to severe pain.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Indomethacin 100 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, indomethacin, for local or systemic absorption. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that play a role in pain and inflammation. By reducing prostaglandin synthesis, indomethacin effectively decreases inflammation and pain.
This formulation is particularly useful for patients who may have difficulties swallowing oral medications or for those who require immediate onset of action, as the rectal route can provide both local and systemic effects. The 100 mg dose of indomethacin in the suppository form is often prescribed for the treatment of various inflammatory conditions such as moderate to severe rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis. It may also be used to treat pain associated with these conditions.
Rectal suppositories like this one can bypass the gastrointestinal tract, which may be advantageous in patients with nausea, vomiting, or gastrointestinal disorders that could affect the absorption of oral medications. Additionally, this route can avoid the first-pass metabolism in the liver, potentially resulting in a more predictable response to the medication.
It is important for patients and prescribers to be aware that, like other NSAIDs, indomethacin can cause side effects, including gastrointestinal irritation and an increased risk of cardiovascular and thrombotic events. Therefore, it should be used with caution in patients with a history of cardiovascular disease or gastrointestinal bleeding. Monitoring for adverse effects is recommended, and patients should be advised to report any unusual symptoms to their healthcare provider.
For optimal use, the suppository should be stored in a cool place to maintain its solid form before administration. Patients should be instructed on the proper technique for inserting rectal suppositories to ensure the medication is delivered effectively.
If you have any questions or require further information about the Indomethacin 100 mg Rectal Suppository formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and prescribers to ensure the safe and appropriate use of this medication.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. When formulated as a 100 mg rectal suppository, indomethacin is used to treat moderate to severe pain, inflammation, and fever. It is particularly useful in conditions such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, and gout. While the rectal route provides a local effect with less systemic absorption compared to oral administration, it is important to be aware of potential drug interactions.
Indomethacin, like other NSAIDs, can interact with various medications, potentially increasing the risk of adverse effects or affecting the therapeutic efficacy of concomitant drugs. Concurrent use of indomethacin with anticoagulants (e.g., warfarin) or antiplatelet agents (e.g., aspirin, clopidogrel) can increase the risk of bleeding. Patients should be monitored closely for signs of bleeding, and dosage adjustments may be necessary.
Combining indomethacin with other NSAIDs, including selective cyclooxygenase-2 inhibitors, should generally be avoided due to the increased risk of gastrointestinal toxicity, including ulceration and bleeding. If combination therapy is deemed necessary, it should be done with caution and under close medical supervision.
Indomethacin may also interact with antihypertensive medications, such as ACE inhibitors, angiotensin receptor blockers, beta-blockers, and diuretics. This interaction can reduce the antihypertensive effect and potentially lead to the deterioration of renal function in susceptible individuals. Blood pressure and renal function should be monitored when initiating or adjusting indomethacin treatment in patients on antihypertensive therapy.
Concomitant use of indomethacin with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding. Patients should be advised to report any signs of gastrointestinal distress promptly. Additionally, indomethacin can decrease the clearance of lithium, leading to increased lithium plasma levels and potential lithium toxicity. Lithium levels should be monitored when starting, adjusting, or discontinuing indomethacin therapy.
Indomethacin may also affect the pharmacokinetics of methotrexate by inhibiting its renal clearance, which can lead to methotrexate toxicity. Close monitoring of methotrexate levels and renal function is advised when these drugs are used together. Furthermore, indomethacin can antagonize the effects of diuretics and antihypertensive agents, and it may potentiate the nephrotoxicity of cyclosporine and other nephrotoxic drugs.
Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs should avoid indomethacin, as severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Additionally, caution is advised when indomethacin is administered to patients with preexisting renal or hepatic impairment, as these conditions may be exacerbated.
It is important for prescribers to review the patient's complete medication profile for potential interactions before prescribing indomethacin suppositories. Patients should be instructed to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or concerns regarding the use of indomethacin rectal suppositories or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are substances in the body responsible for pain, fever, and inflammation. When formulated as a 100 mg rectal suppository, indomethacin is designed to be inserted into the rectum where it gradually dissolves or melts, releasing the active medication directly at the site of action or allowing for its absorption into the bloodstream for systemic effects.
The rectal route of administration provides several advantages, particularly for patients who may have difficulty swallowing oral medications or for those who are experiencing nausea and vomiting. This route can also be beneficial when a rapid onset of action is desired or when bypassing the gastrointestinal tract is necessary to avoid irritation or to ensure a more complete absorption of the drug.
Upon insertion, the suppository base, typically made from substances like cocoa butter or a glycerinated gelatin, begins to melt or dissolve at body temperature. This process allows the indomethacin to be released and absorbed through the rectal mucosa. From there, the drug enters the rectal blood vessels and is carried into the systemic circulation. A portion of the drug is also directly absorbed into the local tissues, providing relief at the site of inflammation.
Indomethacin suppositories are commonly used to treat various disease states characterized by pain and inflammation. These include inflammatory disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. Additionally, they may be used to treat acute gouty arthritis or other conditions where immediate pain relief is necessary. The rectal administration of indomethacin can lead to a reduction in swelling, pain, and fever, thereby improving patient mobility and quality of life.
It is important for both patients and prescribers to understand that while indomethacin suppositories can provide significant relief from symptoms, they may also be associated with side effects similar to those of other NSAIDs, such as gastrointestinal irritation or an increased risk of bleeding. Monitoring for adverse effects is essential, and the use of this medication should be individualized based on the patient's overall health status and concurrent medications.
If you have any questions about the use of indomethacin 100 mg rectal suppositories or if you require further information on how this formulation works and its suitability for treating specific conditions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need to ensure appropriate treatment for your patients.
An Indomethacin 100 mg Rectal Suppository is a solid dosage form containing the active ingredient indomethacin at a dose of 100 milligrams. It is designed to be inserted into the rectum, where it dissolves or melts to release the medication, allowing for local or systemic absorption.
Once the suppository is inserted into the rectum, body heat will cause it to dissolve or melt, releasing the indomethacin. The medication is then absorbed through the lining of the rectum into the bloodstream, providing either local relief at the site or systemic effects throughout the body.
Indomethacin rectal suppositories are typically prescribed to individuals who require anti-inflammatory and pain relief medication but are unable to take it orally. It can be used for various conditions, such as inflammatory diseases, certain types of pain, and as directed by a healthcare provider.
The frequency of use for Indomethacin Suppositories will depend on the individual's medical condition and the advice of a healthcare provider. It's important to follow the prescription instructions carefully and not exceed the recommended dosage.
Indomethacin can cause dizziness or drowsiness in some people. It is important to know how you react to the medication before you drive or operate heavy machinery. If you experience these side effects, you should avoid such activities until you feel alert and safe to do so.
Possible side effects can include irritation or discomfort in the rectal area, headaches, gastrointestinal issues such as nausea or indigestion, dizziness, and drowsiness. If you experience any severe or persistent side effects, contact your healthcare provider immediately.
If you miss a dose, insert the missed suppository as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed one and continue with your regular dosing schedule. Do not use double the dosage to make up for a missed one.
Store the suppositories at room temperature, away from heat and direct light, and keep them out of reach of children. Do not freeze them, and do not keep them in the bathroom, due to humidity.
The use of Indomethacin Suppositories in children should only be under the advice and guidance of a healthcare provider. Dosages and appropriateness for pediatric use will vary based on the child's condition and age.
The use of indomethacin during pregnancy or while breastfeeding should be discussed with a healthcare provider. They will consider the potential risks and benefits before making a recommendation based on your particular situation.
Avoid using other rectal medications or products unless instructed by your healthcare provider. Also, avoid consuming alcohol as it can increase the risk of gastrointestinal bleeding when taken with NSAIDs like indomethacin. Additionally, inform your doctor of all medications you are currently taking to avoid potential interactions.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
