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Liothyronine 7.5 mcg/mL Transdermal Gel

Liothyronine 7.5 mcg/mL Transdermal Gel is a customized compounded medication at Bayview Pharmacy, tailored for hypothyroidism, fatigue, and weight management.
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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Liothyronine Sodium
Topical Gel
65afed05c38e324419931a07

Formula Information

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Liothyronine 7.5 mcg/mL Transdermal Gel is a specialized medication formulated for the management of certain thyroid-related conditions. Liothyronine, the active ingredient, is a synthetic form of triiodothyronine (T3), which is a hormone naturally produced by the thyroid gland. This hormone plays a crucial role in regulating metabolism, energy production, and many other vital bodily functions. The transdermal delivery system of this medication is designed to allow for the direct application of liothyronine to the skin, where it is absorbed into the bloodstream. This method of administration can be particularly beneficial for patients who have difficulties with oral ingestion or require a steady release of medication over time.

The semisolid gel formulation is dispensed through a pump mechanism, which ensures that each dose is measured accurately, reducing the risk of dosing errors. The consistency of the gel allows for easy application and can be particularly useful for patients who prefer a non-invasive and convenient alternative to oral or injectable forms of medication. The transdermal route also bypasses the gastrointestinal tract, which can be advantageous in patients with malabsorption issues or those on medications that interfere with the absorption of oral thyroid preparations.

This transdermal gel is indicated for the treatment of hypothyroidism, a condition where the thyroid gland does not produce sufficient amounts of thyroid hormones. It may also be used in the management of myxedema coma, a severe form of hypothyroidism, and in the suppression of thyroid-stimulating hormone (TSH) in the treatment of euthyroid goiters and in the management of thyroid cancer. By providing a consistent and controlled release of liothyronine, this formulation can help to normalize thyroid hormone levels, thereby improving symptoms such as fatigue, weight gain, and cold intolerance associated with hypothyroidism.

It is important for patients and prescribers to be aware that the use of liothyronine requires careful monitoring of thyroid function tests to ensure therapeutic levels are achieved without causing hyperthyroidism. The transdermal application may also lead to skin reactions, and the site of application should be rotated to prevent skin irritation. As with any medication, adherence to prescribed dosing and regular follow-up with healthcare providers are essential for optimal treatment outcomes.

If you have any questions or require further information about the Liothyronine 7.5 mcg/mL Transdermal Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing support and guidance to ensure the safe and appropriate use of this medication.

Drug Interactions

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Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (T3) and is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used in the management of myxedema coma and sometimes in the treatment of thyroid cancer. The transdermal gel formulation is designed to deliver a consistent dose of liothyronine through the skin, which can be beneficial for patients who have difficulties with oral administration or for whom gastrointestinal absorption may be impaired.

When considering the use of liothyronine 7.5 mcg/mL transdermal gel, it is important to be aware of potential drug interactions that may affect the efficacy of the treatment or cause adverse effects. Liothyronine can interact with a variety of medications, including antidiabetic drugs, anticoagulants, antidepressants, and other medications that affect thyroid hormone levels or function.

For instance, liothyronine may enhance the effects of anticoagulants such as warfarin, which could increase the risk of bleeding. Patients on anticoagulant therapy should have their clotting status closely monitored, and dosage adjustments may be necessary. Additionally, liothyronine can affect blood sugar levels, which may require adjustments in the dosing of insulin or oral hypoglycemic agents for diabetic patients.

Some antidepressants, particularly tricyclics, may have their effects increased by liothyronine, and careful monitoring is advised when these drugs are used concurrently. Conversely, liothyronine's effectiveness may be reduced by medications that decrease thyroid hormone levels or interfere with its action, such as glucocorticoids, beta-blockers, and some anticonvulsants. It is also important to note that certain substances, including soybean flour, cottonseed meal, walnuts, dietary fiber, and calcium or iron supplements, can decrease the absorption of thyroid hormones and should not be taken within several hours of applying the transdermal gel.

Patients should be advised to inform their healthcare provider of all medications, supplements, and over-the-counter drugs they are taking to ensure proper management of potential interactions. Regular monitoring of thyroid function tests is recommended to adjust the dose of liothyronine as necessary. If you have any questions or concerns regarding the use of liothyronine 7.5 mcg/mL transdermal gel or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Liothyronine is a synthetic form of triiodothyronine (T3), which is a thyroid hormone naturally produced by the thyroid gland. The primary function of T3 is to regulate the body's metabolism, which includes the rate at which the body uses energy, produces heat, and consumes oxygen. When the thyroid gland does not produce sufficient amounts of thyroid hormones (a condition known as hypothyroidism), liothyronine can be prescribed to supplement the deficiency and help restore normal metabolic functions.

The 7.5 mcg/mL transdermal gel formulation of liothyronine is designed to deliver the hormone directly through the skin, into the systemic circulation. This route of administration can be particularly beneficial for patients who have difficulties with oral administration, such as gastrointestinal malabsorption issues, or for those who prefer a more steady release of medication throughout the day, which can sometimes be achieved with transdermal systems.

The gel is compounded in a semisolid base that allows for the medication to be evenly distributed throughout the formulation, ensuring consistent dosing with each application. The base is designed to facilitate the penetration of liothyronine through the skin barrier, where it can then enter the bloodstream. The use of a pump mechanism for dispensing the gel provides a convenient and hygienic method for patients to apply the medication, while also allowing for precise dosing. Each pump delivers a measured dose of the gel, which can be applied to an area of skin as directed by a healthcare provider.

In terms of treating disease states, this liothyronine transdermal gel is primarily used to treat hypothyroidism. By providing a steady absorption of T3 through the skin, it helps to normalize the metabolic processes that are slowed down when the thyroid is underactive. This can lead to an improvement in symptoms such as fatigue, weight gain, cold intolerance, and depression. Additionally, because the medication bypasses the gastrointestinal tract, it may be advantageous for patients who have conditions that interfere with the absorption of oral medications.

It is important for both patients and prescribers to understand that the effectiveness of the transdermal gel can be influenced by various factors, including the site of application, skin integrity, and other individual patient variables. Regular monitoring of thyroid function tests is necessary to ensure that the dose of liothyronine is appropriate and to adjust the dose as needed.

If you have any questions about this formulation or its use in treating hypothyroidism, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to effectively manage your condition.

Other Uses

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Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (T3), which is primarily used to treat hypothyroidism and various thyroid disorders where there is a deficiency of thyroid hormone. Beyond its conventional usage, there may be other off-label uses for liothyronine transdermal gel that healthcare providers might consider based on their clinical judgment and the specific needs of their patients. Additionally, this transdermal formulation can be beneficial in managing conditions that require a steady release of the hormone over extended periods, potentially improving the consistency of thyroid levels in the bloodstream.

Moreover, in instances of skin disorders that are indirectly related to thyroid function, such as myxedema, where the skin becomes thick and dry, this transdermal gel might offer direct application benefits. Additionally, some emerging research suggests various components of thyroid hormones can influence wound healing processes, which could open up an investigative avenue for the use of transdermal liothyronine in this context. However, such applications would be experimental and should be pursued under the guidance of a healthcare professional, within the context of an appropriate study or clinical trial if applicable.

It should be emphasized that liothyronine transdermal gel is not indicated for weight loss and should not be utilized for this purpose. Its use should be strictly under the direction of a healthcare provider experienced in the treatment of thyroid disorders. For patients and prescribers considering this compound formulation for alternative uses, it's essential to engage in a thorough discussion about the risks, benefits, and supporting evidence behind such applications. We encourage an open dialogue to ensure safety and efficacy and to align with best practice guidelines. If there are any questions or additional information needed regarding the potential uses and administration of liothyronine 7.5 mcg/mL transdermal gel, please do not hesitate to reach out to us at Bayview Pharmacy for further assistance.

Frequently Asked Questions

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What is Liothyronine 7.5 mcg/mL Transdermal Gel?

Liothyronine 7.5 mcg/mL Transdermal Gel is a medication formulated for the treatment of certain conditions related to thyroid hormone deficiency, such as hypothyroidism. The active ingredient, Liothyronine, is a synthetic form of the thyroid hormone T3 and is delivered through the skin via a transdermal gel.

How should I use this transdermal gel?

This transdermal gel is applied directly to the skin. The pump mechanism dispenses a measured dose of the gel, which you should spread thinly over the area of skin as directed by your healthcare provider. Do not cover the area with bandages or dressings unless instructed to do so.

How often do I need to apply Liothyronine Transdermal Gel?

The frequency of application will be determined by your prescriber based on your individual treatment needs. Follow the dosing instructions provided by your healthcare provider or pharmacist.

What are the advantages of using a transdermal gel for medication?

A transdermal gel allows medication to be absorbed directly through the skin, which can provide a steady release of the active ingredient into the bloodstream. This method may reduce the likelihood of systemic side effects compared to oral medications and can be beneficial for patients who have difficulties with oral administration.

Where on my body should I apply the gel?

Your healthcare provider will advise you on the most appropriate application site(s) for the gel. Common areas include the inner wrists, arms, or thighs. It is important to rotate the application sites to prevent skin irritation.

Can I shower or swim after applying the gel?

It is best to wait for a certain amount of time, typically 1 to 2 hours, after applying the gel before showering or swimming to ensure proper absorption. Your pharmacist or healthcare provider can give you specific instructions regarding your situation.

What should I do if I miss a dose?

If you miss a dose of Liothyronine Transdermal Gel, apply it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double doses to catch up.

Are there any side effects associated with Liothyronine Transdermal Gel?

As with any medication, side effects may occur. Common side effects can include skin irritation at the application site, itching, or rash. More serious side effects may include symptoms of hyperthyroidism such as sweating, rapid heartbeat, nervousness, or insomnia. Contact your healthcare provider if you experience any severe or concerning symptoms.

How should I store the medication?

Store the gel at room temperature away from direct sunlight and heat. Do not freeze. Keep the container tightly closed when not in use and keep the medication out of reach of children and pets.

Can I use other skin products on the same area where I've applied the gel?

It is generally recommended to avoid using other skin products, such as lotions or creams, on the same area where you've applied the thyroid gel to prevent alteration of the medication's absorption. Discuss with your pharmacist about the appropriate timing for the use of other skin products.

What should I do if I accidentally get the gel in my eyes or mouth?

If the medication comes into contact with your eyes or mouth, rinse the area thoroughly with water. While the medication is intended for topical use only, incidental contact with eyes or mouth should be non-hazardous, but it's always best to consult your healthcare provider or seek medical attention if you are concerned about exposure.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Related Formulas

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NY, NJ, NH, FL, and ME. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Liothyronine 7.5 mcg/mL Transdermal Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)