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The Lorazepam 2 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to deliver the active medication. This route of administration is particularly useful for patients who are unable to take medications orally. The lorazepam in this formulation is absorbed either locally or systemically to exert its therapeutic effects.
Lorazepam is a benzodiazepine that is commonly used to treat anxiety disorders, which can include generalized anxiety disorder and panic disorder. Additionally, lorazepam can be used to alleviate symptoms of alcohol withdrawal. The rectal suppository form of lorazepam ensures continued medication administration when oral routes are not feasible, such as in cases of persistent vomiting or pre-surgical preparation.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Lorazepam 2 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, lorazepam, for local or systemic absorption. This route of administration can be particularly useful for patients who are unable to take medications orally due to nausea, vomiting, or difficulty swallowing. Lorazepam is a benzodiazepine that is commonly used for its anxiolytic, sedative, and anticonvulsant properties. It works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that has inhibitory effects on the nervous system, leading to a calming effect on the body.
The lorazepam rectal suppository is indicated for various disease states, including anxiety disorders, where it can help alleviate symptoms of excessive worry and tension. It is also used in the management of seizure disorders, such as epilepsy, as it can help control or prevent seizures. Additionally, lorazepam is employed in the preoperative setting to relieve anxiety and produce sedation before surgical or diagnostic procedures. Its rectal administration is particularly beneficial in situations where oral administration is not feasible or when rapid systemic absorption is desired.
For patients and prescribers considering the use of Lorazepam 2 mg Rectal Suppository, it is important to be aware of the potential side effects, which may include drowsiness, dizziness, weakness, and unsteadiness. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It is also crucial to consider the patient's overall medication profile to avoid interactions with other CNS depressants, which can potentiate the effects of lorazepam. As with any medication, the use of lorazepam should be individualized based on the patient's specific condition and response to therapy.
If you have any questions or require further information about Lorazepam 2 mg Rectal Suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to ensure the safe and appropriate use of this medication.
Lorazepam is a benzodiazepine that is commonly used for the management of anxiety disorders, insomnia due to anxiety or transient situational stress, and as a medication for sedation before surgery. It may also be used to treat seizure disorders and to provide sedation for mechanically ventilated patients. As a rectal suppository, lorazepam can be particularly useful in patients who have difficulty swallowing or when oral administration is not feasible.
When considering the use of lorazepam rectal suppositories, it is important to be aware of potential drug interactions that may affect the efficacy and safety of the medication. Lorazepam, like other benzodiazepines, can cause central nervous system (CNS) depression. Therefore, concurrent use with other CNS depressants such as opioids, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, anticonvulsants, antihistamines, and alcohol can enhance the sedative effects of lorazepam, potentially leading to excessive sedation, respiratory depression, coma, or even death.
Medications that inhibit the cytochrome P450 3A4 (CYP3A4) enzyme can increase the levels of lorazepam in the body, potentially leading to increased sedation and risk of side effects. Examples of CYP3A4 inhibitors include ketoconazole, itraconazole, and ritonavir. Conversely, medications that induce CYP3A4, such as rifampin, carbamazepine, and St. John's Wort, may decrease the levels and effectiveness of lorazepam.
Concomitant use of lorazepam with probenecid may result in a more prolonged half-life and decreased total clearance of lorazepam due to inhibition of renal excretion of lorazepam's glucuronide metabolites. Additionally, the use of lorazepam with valproate may result in increased plasma concentrations and potentiated effects of lorazepam due to inhibition of hepatic metabolism.
It is also important to consider the potential for pharmacodynamic interactions. For example, the use of lorazepam with other medications that have anticholinergic properties, such as certain antihistamines, tricyclic antidepressants, and antiparkinsonian drugs, can increase the risk of cognitive impairment, delirium, constipation, urinary retention, and other anticholinergic side effects.
Patients should be advised to avoid the use of lorazepam with other medications without first consulting with their healthcare provider. Prescribers should review the patient's medication history for potential drug interactions before initiating treatment with lorazepam rectal suppositories and monitor patients for signs of excessive sedation and respiratory depression, especially when lorazepam is used with other CNS depressants. Dose adjustments may be necessary when lorazepam is used in combination with other medications that affect its metabolism or pharmacodynamics.
If you have any questions or require further information regarding the use of lorazepam rectal suppositories and potential drug interactions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and appropriate use of this medication.
Lorazepam 2 mg Rectal Suppository is a solid dosage form designed to be inserted into the rectum, where it dissolves or melts at body temperature. Upon administration, the active ingredient, Lorazepam, begins to be absorbed through the rectal mucosa. The rectal route is particularly useful when oral administration is not feasible due to vomiting, unconsciousness, or difficulty swallowing. Additionally, this route can avoid the first-pass metabolism that occurs when medications are taken orally, potentially leading to more efficient absorption of the drug into the systemic circulation.
Lorazepam is a benzodiazepine, which works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that produces a calming effect. This action helps to reduce anxiety, cause sedation, and relax muscles. As such, Lorazepam rectal suppositories may be used in various disease states where these effects are desired. For instance, they can be used for the management of anxiety disorders, providing sedation before medical procedures, treating status epilepticus (a type of severe seizure), and managing agitation in certain neurological conditions.
When using Lorazepam rectal suppositories, it is important to understand that the onset of action may be slightly delayed compared to oral or intravenous routes, but the medication still provides a relatively rapid effect, which is often necessary in acute situations. The suppository base is typically made from a substance like cocoa butter or a glycerinated gelatin that ensures the medication is released promptly and consistently once inserted into the rectum.
For patients and prescribers considering the use of Lorazepam 2 mg Rectal Suppository, it is crucial to be aware of the potential side effects, which may include drowsiness, dizziness, weakness, and unsteadiness. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It is also important to consider the patient's overall medication profile to avoid interactions with other CNS depressants, which can lead to enhanced sedative effects or respiratory depression.
At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to meet the unique needs of our patients. If you have any questions about Lorazepam 2 mg Rectal Suppositories or would like to discuss whether this formulation is appropriate for your patient, please do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries or concerns you may have.
A Lorazepam 2 mg Rectal Suppository is a solid dosage form containing the medication lorazepam at a strength of 2 milligrams. It is designed to be inserted into the rectum, where it dissolves or melts and releases the lorazepam for local or systemic absorption.
Rectal suppositories are inserted into the rectum rather than taken by mouth. This can be beneficial if the patient is nauseated, vomiting, or unable to swallow oral medication. Additionally, the medication is absorbed differently, which can be helpful in certain medical situations.
Lorazepam Rectal Suppositories are often prescribed for the management of anxiety disorders, insomnia due to anxiety, seizures, and can also be used for sedation before surgical or medical procedures.
Wash your hands thoroughly, then remove the suppository from its packaging. Lie on your side with your lower leg straight and your upper leg bent upward. Gently insert the suppository, pointed end first, into the rectum. Remain lying down for a few minutes and try to hold in the suppository for at least 15 minutes if possible to ensure full absorption of the medication.
The onset of action for a Lorazepam Rectal Suppository can vary, but generally, effects can be noticed within 15 to 30 minutes after administration. It can take longer depending on individual factors and the rate of absorption.
As with any medication, Lorazepam Rectal Suppositories can have side effects. Common side effects include drowsiness, dizziness, weakness, and unsteadiness. However, it's important to contact your doctor if you experience any severe or concerning symptoms.
Lorazepam Rectal Suppositories may be used in children but should only be administered under the guidance of a healthcare provider. The dosing and appropriateness will depend on the child's age, weight, and medical condition.
Store Lorazepam Rectal Suppositories at room temperature away from light and moisture. Keep them in their original packaging until ready to use and out of reach of children and pets.
If you miss a dose, use the suppository as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the next one at your usual time. Do not double the dose to catch up.
Lorazepam may interact with other medications, so it's important to discuss with your healthcare provider all medicines you are currently taking, including prescription, over-the-counter drugs, and herbal supplements, before using Lorazepam Rectal Suppositories.
Since lorazepam can cause drowsiness and dizziness, you should not drive or operate heavy machinery until you know how the medication affects you and until the initial effects have worn off.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
