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The Meclizine HCl 50 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon administration, the suppository dissolves or melts, facilitating the release of Meclizine Hydrochloride for absorption. This medication is primarily used to manage and treat conditions such as nausea, vomiting, and dizziness associated with motion sickness. Additionally, it may be prescribed for the management of vertigo and balance disorders related to the vestibular system. The rectal route of administration provides an alternative for patients who may have difficulties with oral intake or require rapid symptom control.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Meclizine HCl 50 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active pharmaceutical ingredient, Meclizine HCl, for local or systemic absorption. This route of administration can be particularly beneficial for patients who are unable to take medications orally due to nausea, vomiting, or difficulty swallowing. Meclizine is an antihistamine that is commonly used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness, and it may also be used to manage symptoms associated with vestibular disorders such as vertigo.
The 50 mg dose of Meclizine HCl in the rectal suppository form ensures that a sufficient amount of the drug is delivered directly into the bloodstream, bypassing the gastrointestinal tract, which can be advantageous in situations where the oral route is compromised. This can lead to a more predictable pharmacokinetic profile and potentially reduce gastrointestinal side effects. The rectal route can also provide a relatively quick onset of action, which is crucial for patients seeking rapid relief from acute symptoms.
When using Meclizine HCl rectal suppositories, it is important for patients and prescribers to be aware of the potential side effects, which may include drowsiness, dry mouth, blurred vision, or constipation. Caution is advised when performing tasks that require mental alertness, such as driving or operating heavy machinery. Additionally, patients with certain medical conditions or those taking other medications should consult with a healthcare provider to ensure the safe use of this medication.
Bayview Pharmacy's team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the unique needs of each patient. Our pharmacists are available to answer any questions and provide guidance on the proper use of Meclizine HCl rectal suppositories. We work closely with prescribers to ensure that the formulation is tailored to the specific requirements of the patient, taking into account any allergies, sensitivities, or other medications they may be taking. If you have any questions or need further information about this formulation, please do not hesitate to reach out to us.
Meclizine HCl, an antihistamine with antiemetic and antivertigo properties, is used to manage nausea, vomiting, and dizziness associated with motion sickness and vestibular disorders. When formulated as a 50 mg rectal suppository, meclizine is absorbed through the rectal mucosa, which can be beneficial for patients who are unable to take medications orally. However, it is important to consider potential drug interactions when prescribing or using this medication.
Meclizine is metabolized by the liver and may interact with other medications that affect hepatic enzymes, particularly CYP2D6. Inhibitors of this enzyme, such as quinidine, selective serotonin reuptake inhibitors (SSRIs), and certain beta blockers, may increase meclizine plasma levels, potentially leading to enhanced effects or adverse reactions. Conversely, inducers of CYP2D6, such as rifampin and St. John's Wort, may decrease the efficacy of meclizine by increasing its metabolism.
Additionally, meclizine has central nervous system (CNS) depressant effects and may enhance the sedative properties of other CNS depressants, including alcohol, benzodiazepines, opioids, tricyclic antidepressants, and other antihistamines. Patients should be advised to avoid or limit the use of alcohol and other CNS depressants while using meclizine suppositories to prevent excessive sedation and dizziness.
Anticholinergic drugs, such as atropine, scopolamine, and some antipsychotic medications, can also interact with meclizine. The concurrent use of these medications may increase the risk of anticholinergic side effects, such as dry mouth, urinary retention, constipation, and confusion, especially in the elderly. Caution is advised when co-administering these drugs with meclizine.
Patients with a history of cardiovascular disease should use meclizine with caution, as it may interact with certain cardiovascular medications, including antihypertensives and antiarrhythmics. Meclizine can potentially affect blood pressure and heart rate, so monitoring is recommended when used in conjunction with these medications.
It is essential for patients and prescribers to be aware of all medications, including over-the-counter drugs and herbal supplements, that the patient is taking to identify potential interactions with meclizine. Adjustments in dosing or close monitoring may be necessary to ensure safe and appropriate use of meclizine suppositories. If you have any questions or concerns regarding the use of meclizine HCl 50 mg rectal suppositories or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.
Meclizine HCl, the active ingredient in this formulation, is an antihistamine that is commonly used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness, and to a lesser extent, vertigo and other balance disorders. When formulated as a 50 mg rectal suppository, meclizine is administered via the rectal route, which can be particularly beneficial for patients who are unable to take medications orally due to vomiting or other conditions that affect the gastrointestinal tract.
The rectal suppository is a solid dosage form designed to be inserted into the rectum, where it dissolves or melts at body temperature. Upon administration, the meclizine is absorbed through the rectal mucosa, entering the bloodstream. Additionally, rectal administration can result in more consistent blood levels of the medication, avoiding the first-pass metabolism that occurs when drugs are taken orally and processed through the liver.
Once absorbed, meclizine works by blocking the action of acetylcholine (a neurotransmitter) and histamine at H1 receptors in the brain. This action helps to reduce the activity of the vestibular system, which is responsible for sensing motion and maintaining balance. By dampening the signals that cause nausea, vomiting, and dizziness, meclizine can alleviate the symptoms associated with motion sickness and vertigo.
It is also critical to follow the specific dosing instructions provided by the healthcare provider to ensure optimal efficacy and safety of the medication.
If you have any questions about this formulation or its use in treating motion sickness, vertigo, or related conditions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the information and support you need to make informed decisions about your healthcare or the care of your patients.
A Meclizine HCl 50 mg Rectal Suppository is a solid dosage form containing 50 milligrams of Meclizine Hydrochloride. It is designed to be inserted into the rectum where it dissolves or melts, releasing the medication for absorption into the body to treat conditions such as motion sickness and vertigo.
To use a rectal suppository, first wash your hands thoroughly. Remove any wrapping from the suppository, then lie on your side with your lower leg straightened out and your upper leg bent. Gently insert the suppository into the rectum, pointed end first, pushing it about 1 inch in adults or 1/2 inch in children. Stay lying down for a few minutes so the suppository doesn't come out.
Meclizine can cause drowsiness, so it is not recommended to drive or operate heavy machinery until you know how the medication affects you. If you feel drowsy or sedated, do not drive or engage in activities requiring alertness.
Meclizine HCl suppositories may be used in children, but the dosage may vary based on the child's age and weight. It is essential to consult a healthcare professional for the correct dosage and to determine if it is appropriate for your child.
The frequency of use for Meclizine HCl 50 mg Rectal Suppositories depends on the individual's medical condition and response to treatment. It is important to follow the dosing instructions provided by your healthcare provider or pharmacist.
Meclizine HCl Rectal Suppositories should be stored at room temperature away from light and moisture. Do not store in the bathroom or freeze them. Keep suppositories out of reach of children and pets.
If you miss a dose of Meclizine HCl Rectal Suppositories, insert one as soon as you remember, then continue with your regular dosing schedule. However, if it is almost time for your next dose, skip the missed dose and resume your usual schedule. Do not double the dose to catch up.
Like all medications, Meclizine HCl rectal suppositories may cause side effects, although not everyone gets them. Some common side effects include drowsiness, dry mouth, and headache. If you experience any severe or concerning symptoms, seek medical attention immediately.
While using Meclizine HCl suppositories, avoid consuming alcohol as it may enhance the drowsiness effect of the medication. Also, consult your healthcare provider about any other medications you are taking to prevent potential interactions.
You should only use Meclizine HCl Rectal Suppositories during pregnancy or while breastfeeding if clearly needed and prescribed by a healthcare provider. Discuss the risks and benefits with your healthcare provider before use.
If you or someone else may have used too many Meclizine HCl Rectal Suppositories, seek emergency medical attention immediately. Overdose symptoms may include severe drowsiness, seizures, or difficulty breathing.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
