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Metoclopramide 10 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon administration, the suppository dissolves or melts, facilitating the release of metoclopramide for local or systemic absorption. This formulation is primarily used to treat conditions such as gastroesophageal reflux disease (GERD), diabetic gastroparesis, and to prevent nausea and vomiting associated with chemotherapy, radiation treatment, or surgery. Metoclopramide works by enhancing the motility of the upper gastrointestinal tract, which accelerates gastric emptying and improves symptoms related to the aforementioned disease states.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Metoclopramide 10 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active pharmaceutical ingredient, metoclopramide, for local or systemic absorption. This route of administration can be particularly beneficial for patients who are unable to take medications orally due to nausea, vomiting, or difficulty swallowing. Metoclopramide is a dopamine antagonist that is commonly used for its prokinetic and antiemetic effects. It works by enhancing the motility of the upper gastrointestinal tract without increasing the production of secretions, thereby facilitating gastric emptying and reducing the risk of gastroesophageal reflux.
The rectal suppository form of metoclopramide is indicated for the treatment of various conditions, including gastroparesis, a condition characterized by delayed gastric emptying, and for the management of nausea and vomiting associated with chemotherapy, surgery, or as a result of certain medical conditions. It is also used in the treatment of refractory GERD (gastroesophageal reflux disease) when oral administration is not possible. The rectal route provides a reliable means of administration for patients experiencing emesis, ensuring that the medication is absorbed and can exert its therapeutic effects.
When using Metoclopramide 10 mg Rectal Suppository, it is important for both patients and prescribers to be aware of potential side effects, which may include drowsiness, fatigue, restlessness, and, less commonly, extrapyramidal symptoms such as acute dystonic reactions. Long-term use of metoclopramide can lead to tardive dyskinesia, a serious movement disorder that is often irreversible. Therefore, metoclopramide should be used at the lowest effective dose for the shortest duration necessary. Additionally, patients with underlying conditions such as Parkinson's disease, a history of depression, or those taking certain medications may require careful monitoring or dose adjustments.
For optimal results, the suppository should be stored in a cool place to maintain its solidity and ensure proper dissolution upon administration. Patients should be instructed on the correct method of insertion and the importance of hygiene to prevent infection. As with any medication, adherence to the prescribed regimen is crucial for the effectiveness of the treatment.
If you have any questions or require further information about Metoclopramide 10 mg Rectal Suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to ensure the safe and appropriate use of this medication.
Metoclopramide is a medication that works by blocking dopamine receptors in the chemoreceptor trigger zone of the brain, which helps to prevent nausea and vomiting. It also enhances the motility of the upper gastrointestinal tract, which can be beneficial in conditions where gastric emptying is delayed. As a rectal suppository, metoclopramide is used when oral administration is not possible, such as with severe nausea and vomiting, gastroparesis, or in patients who are unable to swallow tablets.
When considering the use of metoclopramide rectal suppositories, it is important to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. Metoclopramide can interact with a variety of medications, leading to either increased or decreased effects of metoclopramide or the concomitant medication.
Concomitant use of metoclopramide with central nervous system (CNS) depressants, such as alcohol, sedatives, and hypnotics, can potentiate the sedative effects of these drugs. Caution is advised when metoclopramide is used with other medications that have a sedative effect. Similarly, antipsychotic medications, particularly those with dopamine antagonist properties, may have additive effects when used with metoclopramide, increasing the risk of extrapyramidal symptoms.
Metoclopramide may also interact with monoamine oxidase inhibitors (MAOIs), as the combination can increase the risk of hypertensive crises due to the blockade of dopamine receptors by metoclopramide. It is generally recommended to avoid the concurrent use of MAOIs and metoclopramide.
Drugs that are known to prolong the QT interval should be used with caution in patients receiving metoclopramide, as there is a potential for additive effects on the QT interval, which can increase the risk of serious cardiac arrhythmias, including torsades de pointes.
Metoclopramide can also affect the absorption of other drugs by altering gastric motility. For example, the absorption of digoxin and certain other medications may be reduced when used concurrently with metoclopramide. Conversely, the rate of absorption of certain drugs, such as acetaminophen, may be increased when taken with metoclopramide.
Furthermore, metoclopramide is a substrate of CYP2D6, and inhibitors of this enzyme, such as fluoxetine and paroxetine, can increase plasma levels of metoclopramide, potentially leading to an increased risk of adverse effects. Conversely, inducers of CYP2D6, such as rifampin, may decrease the plasma levels of metoclopramide, reducing its efficacy.
It is also important to note that metoclopramide can increase the gastrointestinal absorption of certain drugs, such as cyclosporine, leading to potentially higher blood levels and increased risk of toxicity. Careful monitoring of cyclosporine levels is advised when used with metoclopramide.
Lastly, metoclopramide may antagonize the prokinetic effects of anticholinergic drugs and opioid analgesics, as these medications can slow down gastrointestinal motility, which is counterproductive to the action of metoclopramide.
Given the potential for significant drug interactions, it is crucial for prescribers to review the patient's current medication regimen before initiating treatment with metoclopramide rectal suppositories. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or concerns regarding the use of metoclopramide rectal suppositories or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.
Metoclopramide is a medication that is commonly used to treat certain conditions related to the gastrointestinal tract. When formulated as a 10 mg rectal suppository, it serves as an alternative route of administration, particularly beneficial for patients who may have difficulty swallowing tablets or for those who are vomiting and cannot keep oral medications down. The rectal suppository is designed to be inserted into the rectum, where it then dissolves or melts, allowing the active ingredient, metoclopramide, to be absorbed through the rectal mucosa into the bloodstream.
The mechanism of action of metoclopramide involves its antagonistic effects on dopamine receptors in the chemoreceptor trigger zone (CTZ) of the central nervous system, which is part of the area postrema in the medulla. By blocking dopamine receptors, metoclopramide inhibits signals to the vomiting center of the brain, thus preventing nausea and vomiting. Additionally, metoclopramide enhances the motility of the upper gastrointestinal tract without increasing the production of secretions. It does this by increasing the amplitude of gastric contractions, improving the relaxation of the pyloric sphincter, and accelerating gastric emptying and intestinal transit. This prokinetic effect makes it useful in treating conditions such as gastroparesis, where the stomach does not empty normally.
Furthermore, metoclopramide has antiemetic properties due to its antagonism of serotonin (5-HT3) receptors in both the central nervous system and the peripheral nervous system. This action is particularly useful in the management of chemotherapy-induced nausea and vomiting, as well as postoperative nausea and vomiting. The rectal route of administration can provide a more consistent absorption profile, which is especially important in patients who are unable to take oral medications or maintain consistent levels of medication due to vomiting.
These side effects should be monitored, especially with long-term use. Additionally, metoclopramide is contraindicated in patients with gastrointestinal obstruction, perforation, or hemorrhage, and should be used with caution in patients with a history of seizure disorders or Parkinson's disease.
As compounding pharmacists at Bayview Pharmacy, we are committed to providing high-quality, patient-specific formulations. We are available to answer any questions regarding the use of metoclopramide rectal suppositories, their proper storage, handling, and administration techniques. We can also provide guidance on potential drug interactions and contraindications to ensure safe and appropriate use of this medication. If you have any questions or require further information, please do not hesitate to reach out to us.
Metoclopramide 10 mg Rectal Suppositories are used for the management of gastrointestinal conditions such as nausea, vomiting, and delayed gastric emptying. It may also be prescribed for other conditions as determined by a healthcare professional.
To use a Metoclopramide Rectal Suppository, it is inserted into the rectum using a finger or an applicator. It's important to follow the specific instructions provided by your healthcare provider or the product label, including properly cleansing the area and inserting the suppository past the anal sphincter to ensure it stays in place for proper absorption and effectiveness.
The Metoclopramide suppository, once inserted into the rectum, dissolves or melts, releasing the medication that is then absorbed into the bloodstream through the rectal lining. This allows the medication to exert its effects, such as speeding up gastric emptying and reducing feelings of nausea and vomiting. It may have both local and systemic effects.
Rectal suppositories are advantageous particularly when oral administration is not possible due to vomiting or difficulty swallowing. It's also useful when a fast-acting medication delivery is needed, or when the patient is unconscious or unable to take medications orally. Additionally, it may lead to fewer gastrointestinal adverse effects since it does not pass through the stomach or liver initially.
The potential side effects of Metoclopramide Rectal Suppositories can include drowsiness, dizziness, headache, and gastrointestinal disturbances. More serious side effects could include extrapyramidal symptoms such as involuntary muscle movements or spasms. It is important to contact a healthcare professional if any severe or persistent side effects occur.
No, not everyone can use Metoclopramide Rectal Suppositories. It should not be used by individuals who are allergic to metoclopramide or any components of the suppository. It should also be avoided in patients with certain medical conditions or those taking certain medications. Always consult a healthcare provider before using this medication to ensure it is safe for you.
The onset of action for Metoclopramide Rectal Suppositories can vary by individual, but effects are typically observed within one to two hours following administration. Always consult your healthcare provider for advice tailored to your specific condition and response to treatment.
Metoclopramide Rectal Suppositories should be stored at room temperature, away from light and moisture. Keep them in their original packaging until ready to use, and store them in an area out of reach of children and pets. Check the product label or consult with a pharmacist for specific storage instructions.
The use of Metoclopramide Rectal Suppositories during pregnancy or breastfeeding should only be considered if the potential benefit justifies the potential risk to the fetus or infant. It is crucial to consult a healthcare provider before using this medication if you are pregnant or breastfeeding.
If you miss a dose of the Metoclopramide Rectal Suppository, you should take it as soon as you remember, except if it's near the time for your next dose. In that case, you should skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. For more specific advice, contact your healthcare provider.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
