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The Phenytoin Sodium 200 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon administration, it dissolves or melts, facilitating the release of phenytoin sodium for both local and systemic absorption. This formulation is primarily used in the management of seizures, offering an alternative route of administration for patients unable to take oral medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Phenytoin Sodium 200 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, phenytoin sodium, for systemic absorption. Phenytoin is a well-established anticonvulsant drug used primarily in the management of epilepsy. It works by stabilizing the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing the membrane sodium gradient. This action helps to limit the spread of seizure activity and reduces the seizure's occurrence without causing sedation.
This particular formulation is beneficial for patients who are unable to take oral medications due to various reasons such as vomiting, unconsciousness, or difficulty swallowing. Rectal administration can provide a more consistent absorption rate in such cases and is particularly useful in emergency situations where rapid control of seizure activity is necessary. Phenytoin's efficacy extends to the prevention and treatment of seizures occurring during or after neurosurgery.
Phenytoin suppositories are compounded with precision to ensure the correct dosage and uniformity of the active ingredient. It is crucial for prescribers to be aware that the dosing of phenytoin via the rectal route may differ from oral dosing due to variations in absorption. Monitoring of phenytoin serum levels may be necessary to adjust the dose accordingly. Additionally, patients should be monitored for potential side effects, which can include ataxia, nystagmus, slurred speech, and mental confusion, among others. Long-term use of phenytoin may lead to folate deficiency, and supplementation may be advised.
It is important for both patients and prescribers to understand that while phenytoin rectal suppositories are an alternative route of administration, they should be used in accordance with a healthcare professional's guidance. For any questions regarding the formulation, dosing, administration, or potential side effects of Phenytoin Sodium 200 mg Rectal Suppository, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing support and information to ensure the safe and appropriate use of this medication.
Phenytoin sodium is an anticonvulsant medication used to treat and manage seizures. When formulated as a 200 mg rectal suppository, it is intended for administration via the rectal route, which can be particularly useful in patients who are unable to take medications orally. The rectal suppository form allows for the medication to be absorbed through the rectal mucosa and enter the systemic circulation, providing therapeutic effects similar to those achieved with oral or intravenous routes.
However, phenytoin is known to interact with a wide range of medications, and these interactions can affect the drug's efficacy and the patient's safety. Phenytoin is a potent inducer of hepatic cytochrome P450 enzymes, which can lead to decreased plasma concentrations and reduced efficacy of drugs metabolized by these enzymes. For example, the effectiveness of certain anticoagulants (such as warfarin), corticosteroids, and oral contraceptives may be reduced when used concurrently with phenytoin. Patients should be closely monitored for changes in the efficacy of these medications and dosage adjustments may be necessary.
Conversely, drugs that inhibit cytochrome P450 enzymes, such as isoniazid, fluconazole, and certain SSRIs, can increase phenytoin levels, potentially leading to toxicity. Signs of phenytoin toxicity include nystagmus, ataxia, slurred speech, and mental confusion. It is crucial to monitor phenytoin serum levels and adjust the dosage as needed when initiating or discontinuing drugs that may affect its metabolism.
Phenytoin also affects the metabolism of other anticonvulsants, such as valproic acid and phenobarbital, which can lead to either increased toxicity or decreased efficacy of these drugs. Additionally, phenytoin's absorption may be affected by drugs that alter gastrointestinal motility, such as anticholinergic agents, which could lead to variable plasma levels and therapeutic effects.
It is also important to note that phenytoin can interact with certain supplements and food. Chronic alcohol use can alter phenytoin metabolism, and acute alcohol intake may either increase or decrease phenytoin serum levels. Folate supplementation may be required as phenytoin can interfere with folate absorption, potentially leading to deficiency.
Given the complexity of these interactions, it is essential for prescribers to thoroughly review a patient's medication regimen before prescribing phenytoin rectal suppositories. Patients should be advised to inform their healthcare provider of all medications, supplements, and herbal products they are taking. Regular monitoring of drug levels and clinical response should be performed to ensure therapeutic effectiveness and to avoid adverse effects. If you have any questions or require further information regarding drug interactions with phenytoin rectal suppositories, please reach out to us at Bayview Pharmacy for assistance.
Phenytoin Sodium is an anticonvulsant medication that is commonly used to manage and prevent seizures in various forms of epilepsy. The 200 mg Phenytoin Sodium Rectal Suppository is a solid dosage form designed for rectal administration, which can be particularly useful in patients who are unable to take medications orally due to vomiting, unconsciousness, or other conditions that affect the gastrointestinal tract.
The rectal suppository is inserted into the rectum, where it begins to dissolve or melt at body temperature. As the suppository base dissolves, it releases the active ingredient, Phenytoin Sodium, which is then absorbed through the rectal mucosa. The rectal route bypasses the stomach and first-pass metabolism in the liver, which can be advantageous for drugs like phenytoin that have variable oral bioavailability. This allows for more consistent plasma levels of the medication, which is critical for the management of seizure disorders.
Once absorbed, Phenytoin Sodium works by stabilizing the neuronal membrane and reducing the excitability of the central nervous system. It does this by inhibiting voltage-gated sodium channels, which decreases the repetitive firing of action potentials in the neurons. This action helps to prevent the spread of seizure activity in the brain and can terminate ongoing seizures.
It is important for patients and prescribers to understand that the dosing of phenytoin must be individualized and carefully monitored due to its narrow therapeutic index and nonlinear pharmacokinetics. Blood levels of phenytoin should be checked regularly to ensure therapeutic levels are maintained and to avoid toxicity. Additionally, patients should be aware of potential side effects, including dizziness, drowsiness, and ataxia, among others.
For those interested in using the Phenytoin Sodium 200 mg Rectal Suppository, it is crucial to follow the specific instructions provided by the healthcare provider and the compounding pharmacy for proper administration. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with your medication needs and to ensure the safe and appropriate use of Phenytoin Sodium suppositories.
A Phenytoin Sodium 200 mg Rectal Suppository is a solid dosage form containing 200 mg of phenytoin sodium, designed to be inserted into the rectum. It dissolves or melts once inside, releasing the medication for local or systemic absorption to treat various conditions.
Once inserted into the rectum, the suppository begins to dissolve or melt due to body heat, releasing the active drug, phenytoin sodium, which is then absorbed through the rectal mucosa into the bloodstream to exert its therapeutic effects.
Rectal suppositories are made from substances like cocoa butter or a synthetic substitute, which are solid at room temperature and melt at body temperature, allowing for the release of the active medication.
Individuals who require phenytoin sodium for the management of seizures but are unable to take oral medication, such as unconscious patients or those having difficulty swallowing, may be administered this rectal suppository.
The suppository should be stored at room temperature away from light and moisture. Be sure it is kept out of reach of children and pets, in its original packaging until it is ready to be used.
Yes, rectal suppositories like Phenytoin Sodium 200 mg can provide systemic absorption of medication, delivering the active substance directly into the bloodstream through the rich vascular network in the rectum.
Before using a rectal suppository, ensure the bowel is empty to ensure optimal absorption of the medication. Wash your hands thoroughly before and after insertion, and follow the instructions provided by your healthcare provider or the packaging label.
Frequency of use should be as directed by a healthcare provider and according to the specific needs of the patient and their medical condition. The dosing schedule may vary and should be followed precisely as prescribed.
If a dose is missed, it should be administered as soon as it is remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.
Side effects can occur, just as with any medication. Common side effects might include local irritation or discomfort, dizziness, headache, or changes in blood pressure. It's important to contact a healthcare provider if any severe or persistent side effects occur.
Yes, Phenytoin Sodium can interact with other medications, potentially altering their effects. Always inform your healthcare provider of all medications and supplements you are taking before starting new medication like a rectal suppository.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
