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Pilocarpine HCl 0.1% Ophthalmic Liquid

FDA-approved generic
Dose form
Ophthalmic Liquid
Active ingredients
Pilocarpine Hydrochloride

Pilocarpine HCl 0.1% Ophthalmic Liquid is a compounded sterile preparation designed for ocular administration. This formulation contains Pilocarpine Hydrochloride as the active ingredient at a concentration of 0.1%, which is known for its parasympathomimetic effects on the eye. Pilocarpine works by constricting the pupil and facilitating aqueous humor outflow through the trabecular meshwork, thereby reducing intraocular pressure.

This ophthalmic solution is primarily indicated for the treatment of glaucoma, including open-angle glaucoma and angle-closure glaucoma, in situations where lowering intraocular pressure is necessary. Additionally, it may be used to induce miosis (pupil constriction) after an ophthalmic examination or surgery where pupillary constriction is required.

As a compounding pharmacy, Bayview Pharmacy ensures that each batch of Pilocarpine HCl 0.1% Ophthalmic Liquid is prepared following stringent aseptic compounding techniques to maintain sterility and stability, ensuring patient safety and efficacy of the medication.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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Requires a prescription from your own provider. Bayview is a pharmacy and does not prescribe.
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Pilocarpine Hydrochloride
Ophthalmic Liquid
65cf7fef9380895b4e36c67b
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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Pilocarpine HCl 0.1% Ophthalmic Liquid is a prescription medication formulated for the treatment of certain eye conditions. Pilocarpine, as an active ingredient, belongs to a class of drugs known as cholinergic agonists, which work by stimulating the muscarinic receptors in the eye. This action leads to a contraction of the ciliary muscle, which results in a decreased pupil size (miosis) and improved outflow of aqueous humor through the trabecular meshwork. By facilitating the drainage of intraocular fluid, pilocarpine effectively reduces elevated intraocular pressure (IOP), making it a valuable agent in the management of glaucoma, particularly open-angle glaucoma, and ocular hypertension.

In addition to its pressure-lowering effects, pilocarpine is also used to reverse the effects of mydriatic drugs, which are used to dilate the pupils during eye examinations. The 0.1% concentration provides a lower dose of the medication, which may be suitable for patients who require a more gentle effect or who may be sensitive to higher concentrations of the drug. This formulation is typically administered topically as eye drops, with the dosing frequency determined by the severity of the condition and the response to treatment.

Patients using Pilocarpine HCl 0.1% Ophthalmic Liquid should be counseled on the proper administration technique to maximize the drug's efficacy and minimize potential side effects, which may include eye pain, headache, blurred vision, or eye irritation. It is also important for patients to understand that while pilocarpine helps control glaucoma, it is not a cure, and regular use as prescribed is essential for maintaining low IOP and preventing vision loss.

Prescribers should consider the patient's overall medical history, including any other medications being taken, as pilocarpine can interact with other drugs. Additionally, caution is advised in patients with certain pre-existing conditions such as iritis or uveitis. Regular monitoring of IOP and ocular health is recommended to assess the effectiveness of the treatment and to make any necessary adjustments to the therapy.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to meet the unique needs of each patient. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide support to both patients and healthcare providers. If you have any questions about Pilocarpine HCl 0.1% Ophthalmic Liquid or its use in treating eye conditions, please reach out to us for further assistance.

Drug Interactions

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Pilocarpine Hydrochloride (HCl) 0.1% Ophthalmic Liquid is a cholinergic agonist that primarily acts by stimulating the muscarinic receptors in the eye, leading to miosis (pupil constriction) and increased outflow of aqueous humor, which can lower intraocular pressure. It is commonly used in the treatment of glaucoma, specifically open-angle glaucoma, and to manage ocular hypertension. It may also be used to induce miosis during ophthalmic surgery.

When considering the use of Pilocarpine HCl 0.1% Ophthalmic Liquid, it is important to be aware of potential drug interactions that could affect its efficacy and safety. Systemic absorption of pilocarpine from ophthalmic formulations is minimal; however, interactions can still occur, particularly with other ophthalmic agents or systemic medications that affect the cholinergic system.

Concomitant use of pilocarpine with other cholinergic drugs, such as certain Alzheimer's medications (e.g., donepezil, galantamine) or direct-acting cholinomimetics, can enhance the effects of pilocarpine, potentially leading to increased miosis or other cholinergic side effects. Conversely, anticholinergic drugs, including antihistamines, tricyclic antidepressants, and some antipsychotics, may counteract the effects of pilocarpine and reduce its efficacy in lowering intraocular pressure.

Use of pilocarpine with beta-blockers, which are also used to treat glaucoma, may have additive effects in reducing intraocular pressure, but the combination should be monitored for potential over-reduction of intraocular pressure or systemic cardiovascular effects. Similarly, caution is advised when pilocarpine is used with other systemic medications that can affect blood pressure or heart rate, as pilocarpine can have vagotonic effects on the heart.

Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids may also interact with pilocarpine. These medications can delay healing or exacerbate conditions such as keratitis, which could be problematic for patients using pilocarpine post-surgery or for those with compromised corneal conditions.

It is also important to consider the timing of administration when using multiple ophthalmic preparations. To avoid dilution or interference with the action of pilocarpine, it is generally recommended to wait at least 5-10 minutes before administering another ophthalmic agent.

Patients should be advised to inform their healthcare providers of all medications they are taking, including over-the-counter drugs and herbal supplements, to ensure that potential interactions with pilocarpine HCl 0.1% Ophthalmic Liquid are assessed and managed appropriately. If you have any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Pilocarpine HCl 0.1% Ophthalmic Liquid is a prescription medication used in the form of eye drops to treat certain conditions of the eye. Pilocarpine is a cholinergic agonist, which means it works by mimicking the action of a neurotransmitter called acetylcholine. This neurotransmitter is responsible for transmitting signals in the nervous system, including those that control the muscles in the eye.

When pilocarpine is administered as an ophthalmic solution, it primarily acts on the muscarinic receptors in the eye. By stimulating these receptors, pilocarpine causes the circular muscle of the iris (the sphincter pupillae) to contract, resulting in miosis, or constriction of the pupil. This action can help to reduce the intraocular pressure in patients with glaucoma, a disease state characterized by increased pressure within the eye that can lead to optic nerve damage and vision loss if not properly managed. By decreasing the pupil size, pilocarpine also allows for improved outflow of the aqueous humor, the fluid inside the eye, further reducing intraocular pressure.

In addition to its use in glaucoma, pilocarpine ophthalmic solution can also be used to manage ocular hypertension, a condition where the pressure in the eye is higher than normal but not yet at the level of glaucoma. Furthermore, pilocarpine can be used to induce miosis during ophthalmic surgery or to reverse the effects of mydriatic drugs, which are used to dilate the pupils for examination purposes.

It is important for patients and prescribers to understand that pilocarpine should be used with caution in certain populations, including those with inflammatory eye conditions, as it can exacerbate these conditions. Additionally, the use of pilocarpine can cause side effects such as headache, eye pain, visual disturbances, and rarely, systemic effects due to absorption. Patients should be counseled on the proper administration of the eye drops to maximize therapeutic effects and minimize side effects.

For prescribers considering pilocarpine HCl 0.1% Ophthalmic Liquid for their patients, it is essential to evaluate the patient's overall ocular health and medical history to ensure that this medication is appropriate. As compounding pharmacists at Bayview Pharmacy, we are equipped to provide customized formulations of pilocarpine to meet the specific needs of your patients. If you have any questions about this formulation or its suitability for a particular patient, please do not hesitate to reach out to us. We are here to support you in providing optimal care for your patients' eye health.

Frequently Asked Questions

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What is Pilocarpine HCl 0.1% Ophthalmic Liquid used for?

Pilocarpine HCl 0.1% Ophthalmic Liquid is used for treating certain types of glaucoma and other eye conditions that require the reduction of intraocular pressure. It may also be prescribed to reverse the effects of mydriatics—drugs that dilate the pupils—after an eye examination.

How often should I use Pilocarpine HCl 0.1% Ophthalmic Liquid?

The frequency of use for Pilocarpine HCl 0.1% Ophthalmic Liquid will be determined by your healthcare provider based on your specific condition. It is essential to follow the dosing schedule as prescribed and to not adjust your dose without consulting your doctor.

How should I apply Pilocarpine HCl 0.1% Ophthalmic Liquid?

To apply the medication, wash your hands first. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over the eye and place one drop into the pouch, usually as directed by your doctor. Close your eye and gently press your finger to the inner corner of the eye for about 1 minute to prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps if your dose is more than one drop and for your other eye if so directed.

Can I wear contact lenses while using Pilocarpine HCl 0.1% Ophthalmic Liquid?

It is not recommended to wear contact lenses while using Pilocarpine HCl 0.1% Ophthalmic Liquid, as the preservatives in the formulation may be absorbed by soft contact lenses. You should remove contact lenses before application and wait at least 15 minutes before reinsertion. Consult your healthcare provider for specific recommendations regarding contact lens use.

What should I do if I miss a dose?

If you miss a dose of Pilocarpine HCl 0.1% Ophthalmic Liquid, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects of using Pilocarpine HCl 0.1% Ophthalmic Liquid?

Yes, like all medications, Pilocarpine HCl 0.1% Ophthalmic Liquid can cause side effects. Common side effects include eye irritation, headache, brow ache, visual disturbances, and eye pain. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

Can Pilocarpine HCl 0.1% Ophthalmic Liquid interact with other medications?

Yes, pilocarpine can interact with other medications, so it is important to share with your healthcare provider a list of all the drugs you use, including prescription drugs, nonprescription drugs, and herbal products. Do not start, stop, or change the dosage of any medicine without your doctor's approval.

What precautions should I take when using Pilocarpine HCl 0.1% Ophthalmic Liquid?

Before using Pilocarpine HCl 0.1% Ophthalmic Liquid, tell your doctor if you have any allergies, medical history of eye problems, or if you are scheduled for an eye surgery. Use caution when driving or performing duties requiring clear vision until you know how the medication affects you because pilocarpine can cause temporary blurred vision.

How should I store Pilocarpine HCl 0.1% Ophthalmic Liquid?

Store Pilocarpine HCl 0.1% Ophthalmic Liquid at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not use the eye drops after the expiration date on the bottle.

Is it safe to use Pilocarpine HCl 0.1% Ophthalmic Liquid during pregnancy or while breastfeeding?

There is limited data on the use of Pilocarpine HCl 0.1% Ophthalmic Liquid during pregnancy or while breastfeeding, so it should be used only when clearly needed. It is essential to discuss the risks and benefits with your healthcare provider before using this medication if you are pregnant or planning to become pregnant or if you are breastfeeding.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Pilocarpine HCl 0.1% Ophthalmic Liquid
Ophthalmic Liquid
controlled
Twice daily