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The Pregnenolone 25 mg/Progesterone 60 mg/Testosterone 0.5 mg/0.5 mL Topical Cream is a compounded medication that combines three hormones in a semisolid dosage form. This cream is specifically designed to be dispensed from a pump mechanism, which allows for precise dosing and ease of application to the skin. The formulation is intended for localized treatment and is absorbed through the skin to deliver the active ingredients directly to the targeted area.
This hormone therapy cream is commonly used to address a variety of hormone-related conditions. It may be prescribed for symptoms associated with menopause, such as hot flashes and vaginal dryness, as well as for certain cases of androgen deficiency. Additionally, it can be used in the management of conditions like adrenal fatigue, where pregnenolone is beneficial. The combination of hormones in this cream works synergistically to restore hormonal balance and alleviate the symptoms associated with these disease states.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The compounded formulation of Pregnenolone 25 mg/Progesterone 60 mg/Testosterone 0.5 mg per 0.5 mL Topical Cream is a specialized medication prepared at Bayview Pharmacy to address specific patient needs. This semisolid preparation is dispensed in a pump mechanism, which allows for convenient, controlled, and consistent dosing with each application. The cream is designed for topical use, where the active ingredients are either intended for localized treatment or to be absorbed through the skin into systemic circulation.
Pregnenolone is a precursor hormone that can be converted into various other hormones, including progesterone and testosterone. It is used to support memory, mood, and overall brain health. Progesterone is a hormone that plays a vital role in the menstrual cycle and in maintaining the early stages of pregnancy. It may also have a role in improving symptoms related to menopause and may be used in hormone replacement therapy. Testosterone, while typically regarded as a male hormone, is also important in females for maintaining muscle strength, bone density, and sexual function. In men, it is used to treat conditions associated with a deficiency or absence of endogenous testosterone.
This combination cream may be prescribed for various disease states, including hormonal imbalances, menopausal symptoms, andropause symptoms in men, or specific conditions where a combination of these hormones is deemed beneficial by the healthcare provider. The topical route of administration can offer the advantage of localized action with potentially fewer systemic side effects compared to oral administration. Additionally, the use of a topical cream can allow for direct application to areas where treatment is desired, which may enhance the effectiveness of the medication for certain conditions.
It is important for both patients and prescribers to understand that this is a customized medication prepared in a compounding pharmacy. The dosages of pregnenolone, progesterone, and testosterone in this formulation are specifically tailored to meet individual patient needs and should be used under the guidance of a healthcare professional.
For any questions or additional information regarding this compounded formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide support and guidance to ensure the safe and appropriate use of this medication.
The formulation in question contains three hormones: pregnenolone, progesterone, and testosterone, which are intended for topical application. When considering drug interactions, it is important to note that while the systemic absorption of these hormones may be lower with topical administration compared to oral or parenteral routes, interactions can still occur. Patients should be advised to inform their healthcare providers of all medications, supplements, and herbal products they are using to avoid potential interactions.
Pregnenolone is a precursor to various steroid hormones and may potentially interact with medications that affect hormone levels or are metabolized by enzymes that pregnenolone also influences. For example, pregnenolone may affect the metabolism of certain benzodiazepines, barbiturates, or other medications metabolized by the cytochrome P450 enzyme system. Caution is advised when using this formulation with other hormonal therapies, including birth control pills, hormone replacement therapy, or thyroid medications, as it may alter their effects.
Progesterone can interact with drugs that induce or inhibit hepatic enzymes, particularly cytochrome P450 3A4 (CYP3A4). Medications such as ketoconazole, itraconazole, clarithromycin, and grapefruit juice may increase progesterone levels by inhibiting its metabolism, while others like rifampin, carbamazepine, and phenytoin may decrease its effectiveness by inducing its metabolism. Additionally, progesterone may influence the effectiveness of anticoagulant medications, and its use should be monitored closely in patients taking warfarin or similar drugs.
Testosterone, even in small amounts as in this formulation, can interact with a variety of medications. It may enhance the anticoagulant effects of warfarin and other blood thinners, necessitating close monitoring of coagulation parameters. Testosterone may also affect blood glucose levels, which is particularly important for patients taking insulin or other diabetes medications. The concurrent use of corticosteroids or adrenocorticotropic hormone (ACTH) with testosterone may increase the risk of edema, especially in patients with underlying cardiac, renal, or hepatic diseases.
This topical cream is designed to treat conditions related to hormone deficiencies or imbalances, such as certain endocrine disorders, menopausal symptoms, or specific cases of androgen deficiency. The combination of hormones aims to provide a synergistic effect, addressing multiple symptoms or conditions concurrently. However, the precise treatment effects and indications should be determined by a healthcare provider based on individual patient needs.
Patients should be instructed to apply the cream as directed by their healthcare provider, typically to clean, intact skin on areas recommended for application. They should be aware that the application site should not be occluded and that they should avoid skin-to-skin contact with others until the cream has fully dried to prevent inadvertent transfer of hormones.
It is crucial for patients and prescribers to communicate openly about all concurrent medications and health conditions before starting treatment with this hormone-containing topical cream. Adjustments to therapy or additional monitoring may be necessary to safely use this formulation. If you have any questions or require further information regarding potential drug interactions or the management of specific disease states with this formulation, please reach out to us at Bayview Pharmacy for personalized assistance.
The formulation of Pregnenolone 25 mg/Progesterone 60 mg/Testosterone 0.5 mg per 0.5 mL Topical Cream is a compounded medication that combines three naturally occurring hormones, each with distinct physiological effects. This cream is designed to be applied topically, where it can be absorbed through the skin to exert its effects either locally or systemically, depending on the intended use and the specific characteristics of the patient's skin.
Pregnenolone is a precursor hormone that can be converted into various other hormones, including progesterone and testosterone. It is involved in the synthesis of neurosteroids and has been suggested to have memory-enhancing and anti-inflammatory properties. In this formulation, pregnenolone may help to balance other hormone levels and support overall endocrine function.
Progesterone is a key hormone in the regulation of the menstrual cycle and maintenance of pregnancy. It has a variety of roles, including acting as a natural anxiolytic, promoting sleep, and exerting a balancing effect on estrogen. Topical application of progesterone can be used to manage symptoms associated with hormonal imbalances, such as menopausal symptoms, premenstrual syndrome (PMS), and certain forms of menstrual irregularity.
Testosterone, although commonly associated with male physiology, is also an important hormone for women, contributing to muscle strength, bone density, and sexual function. In both men and women, testosterone can help improve libido, energy levels, and mood. The inclusion of testosterone in this formulation can be particularly beneficial for patients experiencing low testosterone levels, which can occur due to aging or other health conditions.
The cream is dispensed in a pump mechanism, which allows for precise dosing and ease of application. The pump dispenses a measured dose of the cream, which can be applied to the skin as directed by a healthcare provider. The cream base is designed to facilitate the absorption of the active ingredients through the skin, allowing them to enter the bloodstream and reach their target tissues. The use of a topical cream can also minimize the risk of gastrointestinal side effects and first-pass metabolism by the liver, which can occur with oral hormone preparations.
This compounded formulation may be used to treat a variety of disease states related to hormonal imbalances or deficiencies. It is important to note that the use of this cream should be guided by a healthcare provider, who can tailor the treatment to the individual needs of the patient based on their specific symptoms and hormone levels. Monitoring hormone levels and adjusting the dose accordingly is crucial to ensure the effectiveness and safety of the treatment.
If you have any questions or require further information about this formulation and its use in treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to both patients and prescribers considering the use of this compounded hormone therapy.
This compounded topical cream has been specifically formulated to deliver a combination of Pregnenolone, Progesterone, and Testosterone at designated doses. It is designed to be used for hormone replacement therapy, targeting various symptoms related to hormonal imbalances or deficiencies. Always use this preparation under the guidance of your healthcare provider.
Apply the cream as directed by your healthcare provider. The pump mechanism dispenses a measured dose of the cream, which you should spread thinly over the skin, typically on an area with minimal hair and good blood flow. Common sites include the inner forearms, thighs, or on the abdomen. Ensure you wash your hands before and after application unless your hands are the treatment site.
The frequency of application will be determined by your healthcare provider based on your specific needs and treatment plan. Follow the prescription label or your healthcare provider's instructions carefully.
No, certain areas of the skin may be more absorbent or sensitive than others. It's generally recommended to apply the cream to areas with relatively thin skin and good blood flow to facilitate absorption. Avoid applying the cream on broken skin, near the eyes, or mucous membranes. Consult with your healthcare provider for more specific instructions on where to apply the cream.
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular application schedule. Do not double up to make up for a missed dose without consulting your healthcare provider.
As with any medication, side effects are possible. These can include skin irritation at the application site, hormone-related changes, or systemic effects. If you notice any adverse effects, contact your healthcare provider immediately.
Store the cream at room temperature away from direct light and heat. Keep the pump bottle tightly closed when not in use and keep out of reach of children and pets to prevent accidental ingestion or misuse.
If you accidentally apply more cream than prescribed, contact your healthcare provider for advice. In most cases, you will be instructed to remove the excess cream with a tissue and wash the area with soap and water. Monitor for any adverse reactions and report them to your healthcare provider.
You should not use this cream if you are pregnant or breastfeeding without consulting your healthcare provider. There could be potential risks to the fetus or nursing child associated with the hormones in this formulation.
The duration of use for this cream will depend on your individual treatment plan outlined by your healthcare provider, disease states, or hormone levels. Long-term use may require regular monitoring through blood tests or physical examinations. Follow your provider's recommendations closely.
Yes, you can cover the application area with clothing once the cream has been fully absorbed into the skin. This typically takes a few minutes. To avoid transferring the medication to others, let the cream dry completely before coming into contact with others or allowing them to handle your clothing.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
