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Allopurinol is a xanthine oxidase inhibitor primarily used to manage hyperuricemia and its associated conditions, such as gout and certain types of kidney stones.
Allopurinol is a xanthine oxidase inhibitor primarily used to manage hyperuricemia and its complications, such as gout and kidney stones. By inhibiting the enzyme xanthine oxidase, allopurinol effectively reduces the production of uric acid, thereby lowering serum urate levels and preventing the formation of urate crystals. This mechanism of action makes it a critical component in the treatment of chronic gout and other conditions associated with excessive uric acid production.
In addition to its role in managing gout, allopurinol is also utilized in the prevention of uric acid nephropathy during cancer chemotherapy, where rapid cell turnover can lead to elevated uric acid levels. The drug is well-absorbed orally, with peak plasma concentrations typically occurring within 1.5 hours after administration. Allopurinol is metabolized to oxypurinol, which also possesses xanthine oxidase inhibitory activity, contributing to its therapeutic effects.
Allopurinol is generally well-tolerated, but prescribers should be aware of potential side effects, including skin rash, gastrointestinal disturbances, and, in rare cases, severe hypersensitivity reactions. It is crucial to adjust the dosage in patients with renal impairment to prevent accumulation and toxicity. Regular monitoring of uric acid levels and renal function is recommended to ensure optimal therapeutic outcomes.
When considering allopurinol for treatment, it is important to evaluate potential drug interactions, as it can interact with medications such as azathioprine, mercaptopurine, and warfarin, necessitating dosage adjustments. By understanding the pharmacological profile and clinical applications of allopurinol, healthcare providers can effectively incorporate it into treatment regimens for patients with hyperuricemia-related conditions.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.
Prescriber sign inA sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
