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Colistimethate Sodium is a potent antibiotic used primarily in the treatment of multidrug-resistant Gram-negative bacterial infections.
Colistimethate Sodium is a potent antibiotic used primarily in the treatment of multidrug-resistant Gram-negative bacterial infections. It is a prodrug of colistin, which is a polymyxin antibiotic that disrupts the bacterial cell membrane, leading to cell death. This API is particularly effective against Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, making it a critical option in combating severe infections where other antibiotics may fail.
Due to its mechanism of action, Colistimethate Sodium is often reserved for cases where alternative treatments are ineffective or contraindicated. It is commonly used in hospital settings for patients with cystic fibrosis or those who are immunocompromised, as these populations are at higher risk for resistant infections. The API is administered via inhalation, intravenous, or intramuscular routes, depending on the specific needs of the patient and the severity of the infection.
While Colistimethate Sodium is a valuable tool in the fight against resistant bacteria, it is important for prescribers to be aware of its potential nephrotoxic and neurotoxic side effects. Monitoring kidney function and adjusting dosages accordingly can help mitigate these risks. Additionally, the use of Colistimethate Sodium should be guided by susceptibility testing to ensure its efficacy against the targeted pathogen.
In the context of compounding, Colistimethate Sodium offers flexibility in formulation, allowing for tailored dosing regimens that meet the specific needs of individual patients. This customization is particularly beneficial in pediatric and geriatric populations, where standard dosing may not be appropriate. By understanding the pharmacokinetics and pharmacodynamics of Colistimethate Sodium, healthcare providers can optimize treatment outcomes while minimizing adverse effects.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.
Prescriber sign inA sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
