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Active pharmaceutical ingredient

Enclomiphene Citrate

Enclomiphene Citrate is a nonsteroidal selective estrogen receptor modulator (SERM) primarily used to address hormonal imbalances, particularly in men with secondary hypogonadism.

Compounded to order
Prescription required
Warwick, Rhode Island

About this ingredient

Enclomiphene Citrate is a nonsteroidal selective estrogen receptor modulator (SERM) primarily used to address hormonal imbalances, particularly in men with secondary hypogonadism. It works by blocking estrogen receptors in the hypothalamus, which stimulates the release of gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH), ultimately promoting endogenous testosterone production.

This API is often considered a safer alternative to traditional testosterone replacement therapies, as it helps restore natural testosterone levels without suppressing the body's own production. Enclomiphene Citrate is also known for its favorable safety profile and minimal risk of adverse effects compared to other hormonal treatments.

In clinical practice, Enclomiphene Citrate is commonly prescribed for men experiencing symptoms of low testosterone, such as fatigue, reduced libido, and decreased muscle mass, while maintaining fertility. Its mechanism of action makes it a valuable option for patients seeking to improve testosterone levels without compromising spermatogenesis.

Additionally, Enclomiphene Citrate has been studied for its potential applications in female infertility, as it can induce ovulation by modulating estrogen feedback mechanisms. This versatility highlights its importance in addressing a range of hormonal and reproductive health concerns.

Available formulations

Compounded formulations containing this ingredient

Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.

Compounding formulary

Formulas we compound with this ingredient

A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.

Common questions

Frequently asked questions

What is enclomiphene used for?

Providers may prescribe enclomiphene off-label as part of hormone therapy for men with low testosterone caused by secondary hypogonadism, when they determine it is appropriate. It is often considered for men who want to raise testosterone while preserving fertility. Enclomiphene is not FDA-approved for this or any use, and only a licensed provider can decide whether it is right for you.

How does enclomiphene work?

Enclomiphene is a selective estrogen receptor modulator (SERM). It blocks estrogen's signal at the pituitary and hypothalamus, which is understood to increase the hormones (LH and FSH) that prompt the testes to make more of the body's own testosterone and support sperm production. It works through the body's own hormone axis rather than adding testosterone from outside.

Does enclomiphene affect fertility?

Because enclomiphene works through the body's natural hormone signals, it generally maintains the body's own sperm production, unlike exogenous testosterone, which can reduce it. Your provider may monitor a semen analysis if fertility is a goal.

Is enclomiphene a controlled substance?

No. Enclomiphene is not a controlled substance and does not require electronic prescribing for controlled substances (EPCS). A valid prescription from a licensed provider is still required.

What side effects can enclomiphene cause?

Reported effects can include headache, hot flashes or flushing, nausea or stomach upset, mood changes, and breast tenderness. Vision changes such as blurring, spots, or flashes can occur with medications in this class; if you notice any change in your vision, stop taking it and contact your provider. Report any effect that concerns you.

Related

Related active ingredients

Other salt forms of this molecule, and ingredients commonly compounded alongside it.

No items found.

Important information

This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.

Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Talk to a compounding pharmacist

Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.