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Verapamil Hydrochloride is a calcium channel blocker that Bayview compounds to a prescriber's order.
Verapamil hydrochloride is a non-dihydropyridine calcium channel blocker used in the management of cardiovascular conditions. It inhibits the entry of calcium ions through slow L-type calcium channels in the myocardium and vascular smooth muscle, which induces vasodilation and reduces myocardial contractility.[1] FDA-approved uses include hypertension, angina, and certain arrhythmias such as supraventricular tachycardia and rate control in atrial fibrillation.[1]
Verapamil is also used off-label for cluster headache prophylaxis and, by intralesional injection, for Peyronie disease.[1] Verapamil undergoes extensive hepatic metabolism by cytochrome P450 3A (CYP3A4) and is a P-glycoprotein inhibitor, so it can interact with other medications, including digoxin, dabigatran, and certain statins.[1]
Prescribers should be aware of potential side effects, including constipation, hypotension, bradycardia, fatigue, and atrioventricular block.[1] Caution is needed in patients with pre-existing cardiac conditions such as systolic dysfunction, and combining verapamil with beta-blockers can cause additive conduction depression and heart failure.[1] Bayview compounds verapamil topical gel on a prescriber's order.
Compounded at Bayview
Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.
For prescribers
Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.
That statement refers to intralesional verapamil, verapamil injected directly into the plaque in a clinician's office, which the AUA says clinicians may offer (Conditional Recommendation, Evidence Strength Grade C). It is not support for a gel rubbed on the skin. The guideline also says clinicians should not offer electromotive therapy with verapamil, and it says nothing at all about the topical gel.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
