Check out our most popular compounded medications! Get Started
Dashboard
Formulas

Amitriptyline HCL 10 mg/ml Transdermal Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Amitriptyline Hydrochloride

Amitriptyline HCL 10 mg/ml Transdermal Gel is a semisolid formulation dispensed through a pump mechanism. This formulation allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredient, Amitriptyline HCL. The gel-like consistency of the formulation enhances the absorption of the drug through the skin. Amitriptyline HCL is commonly used in the treatment of various disease states including depression, anxiety disorders, and certain types of nerve pain.

View more
For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Get started as a patient
Get Started
This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Topical Gel
653077c0698135237fda7733

Formula Information

A small arrow pointing down

Amitriptyline HCL 10 mg/ml Transdermal Gel is a specialized formulation designed for targeted treatment through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the active ingredient, Amitriptyline HCL, is absorbed effectively into the skin for optimal therapeutic effect.

Amitriptyline HCL is a tricyclic antidepressant that works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain. In a transdermal gel form, it can be used to manage a variety of disease states. It is often prescribed for the management of neuropathic pain, a type of chronic pain caused by damage to or dysfunction of the nervous system. It can also be used to treat fibromyalgia, a long-term condition that causes pain all over the body, and certain types of nerve-related pain.

Furthermore, Amitriptyline HCL Transdermal Gel can be used in the treatment of depression, anxiety, and certain types of chronic pain. It is also sometimes used off-label for the treatment of insomnia. The transdermal application allows for a steady release of the medication, which can provide consistent relief over time. It also reduces the risk of systemic side effects compared to oral administration.

It's important to note that the use of Amitriptyline HCL Transdermal Gel should be under the supervision of a healthcare provider. The medication should be applied as directed by the prescriber, usually on a clean, dry, intact skin area. Avoid contact with eyes, nose, mouth, or other sensitive areas. Wash your hands after applying the gel. If you experience any side effects or have any concerns, contact your healthcare provider immediately.

As a team of knowledgeable compounding pharmacists at Bayview Pharmacy, we are here to answer any questions you may have about this formulation. Please do not hesitate to reach out to us for further information or clarification.

Drug Interactions

A small arrow pointing down

Amitriptyline HCL 10 mg/ml Transdermal Gel is a medication that is primarily used to treat certain mental/mood problems such as depression. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. This medication belongs to a class of medications called tricyclic antidepressants. It works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain.

It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter products, and herbal supplements.

Amitriptyline may interact with certain medications such as MAO inhibitors (including isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), anticholinergics (such as certain antihistamines, atropine, belladonna alkaloids), certain drugs for high blood pressure, certain heart medications (such as digoxin, disopyramide), certain antipsychotics (such as phenothiazines, pimozide), terbinafine, certain drugs for irregular heart rhythms (such as quinidine, procainamide).

Also, the effects of certain drugs can decrease when used with Amitriptyline, such as armodafinil, cimetidine, fluconazole, fluvoxamine, haloperidol, phenothiazines, rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (such as phenytoin), other antidepressants (such as fluoxetine, sertraline).

It is also important to note that Amitriptyline can cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation.

Before using Amitriptyline, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Amitriptyline safely.

Remember, this is not a complete list of possible drug interactions. Always consult your healthcare provider to ensure the information applies to your personal circumstances. If you have any questions or concerns, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to help.

How Does it Work

A small arrow pointing down

Amitriptyline HCL 10 mg/ml Transdermal Gel is a unique formulation that allows for the delivery of the active ingredient, Amitriptyline HCL, directly through the skin. This is achieved by incorporating the drug into a gel base that is designed to facilitate the absorption of the drug into the skin. The gel base is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin.

The active ingredient, Amitriptyline HCL, is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help elevate mood. When applied topically in a gel form, Amitriptyline HCL can be absorbed through the skin and into the bloodstream, providing targeted treatment to the area of application. This can be particularly beneficial for localized pain management, as it allows for the direct delivery of the drug to the area of discomfort.

Transdermal delivery of Amitriptyline HCL also offers several advantages over oral administration. It bypasses the first-pass metabolism in the liver, which can lead to a more predictable and sustained therapeutic effect. It also reduces the risk of systemic side effects, as the drug is not distributed throughout the entire body. This makes it a suitable treatment option for patients who may be unable to tolerate oral medications due to gastrointestinal side effects or other issues.

Amitriptyline HCL 10 mg/ml Transdermal Gel can be used to treat a variety of disease states. It is commonly used for the management of neuropathic pain, such as that associated with postherpetic neuralgia or diabetic neuropathy. It may also be used for the treatment of fibromyalgia, a chronic condition characterized by widespread pain and tenderness. Additionally, it can be used off-label for the management of chronic pruritus, or itching, as Amitriptyline HCL has been shown to have antipruritic properties.

Patients should follow the dosing instructions provided by their healthcare provider and should not apply more gel than prescribed. The gel should be applied to clean, dry skin and should not be applied to broken or irritated skin.

If you have any questions about Amitriptyline HCL 10 mg/ml Transdermal Gel, or if you would like more information about how this formulation can be used to treat specific disease states, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

A small arrow pointing down

The Amitriptyline HCL 10 mg/ml Transdermal Gel, besides its conventional use, can be utilized for other indications based on compounding prescriptions provided by healthcare providers. For instance, it may be used for treating fibromyalgia, a condition that results in muscle pain and fatigue. It works by increasing the levels of certain chemicals in the brain that help elevate the mood and alleviate pain. The transdermal delivery also aids in bypassing gastric metabolism, which is beneficial for patients who have problems with oral tolerance.

Further, it may be prescribed for postherpetic neuralgia, a condition characterized by nerve pain following the resolution of shingles. This medication assists in reducing the peripheral neuropathic pain associated with this condition, thus enhancing the patient's quality of life. The Amitriptyline HCL 10 mg/ml Transdermal Gel can also be used off-label for managing pain associated with diabetic neuropathy. It functions by altering the way your body feels pain.

Last but not least, this formulation could also be an alternative for treating depression, although this is more often done with oral forms of Amitriptyline. The transdermal application may offer other benefits in terms of sustained therapeutic levels and potentially fewer side effects.

It is critical to remember that this medication is made on a case-to-case basis guided by individual patient needs and the prescribing physician's judgement. If you are a patient, it is vital to follow the dosing instructions given to you by your healthcare provider and pharmacist. If you're a healthcare provider, please remember to consider the individual response and tolerance to this treatment, and adjust the dosing regimen accordingly.

If you have any questions or concerns about the formulation or its uses, please don't hesitate to reach out to us at any time. As a team of knowledgeable compounding pharmacists at Bayview Pharmacy, we are here to help.

Frequently Asked Questions

A small arrow pointing down

What is Amitriptyline HCL 10 mg/ml Transdermal Gel?

It is a semisolid medication containing Amitriptyline HCL at a concentration of 10 mg/ml and dispensed through a pump mechanism.

What form does Amitriptyline HCL come in?

Amitriptyline HCL in this formulation comes in a gel-like consistency, enabling absorption through the skin for targeted treatment.

How do I apply Amitriptyline HCL 10 mg/ml Transdermal Gel?

You apply the medication by leveraging the pump mechanism, which allows for easy and precise application on the skin area needed.

What is the benefit of the pump mechanism in this formulation?

The pump mechanism ensures a measured dose of the medication is dispensed each time it's used, facilitating precision in application and reducing the risk of over or under-dosing.

Can this formulation be used for all kinds of skin?

Yes, this formulation can be used for all kinds of skin. However, it is advised that you speak to your healthcare provider for guidance, as certain skin conditions may affect the absorption of the medication.

Does the gel have any side effects?

As with any medication, Amitriptyline HCL 10 mg/ml Transdermal Gel can have side effects. Your healthcare provider or pharmacist can give you comprehensive information pertaining to potential side effects.

Is Amitriptyline HCL 10 mg/ml Transdermal Gel absorbed immediately once applied?

Amitriptyline HCL 10 mg/ml Transdermal Gel is designed to be absorbed through the skin gradually. It may take some time after application for the full effects to be felt.

How often should I apply the gel?

The frequency of application should be determined by your healthcare provider based on your individual condition and therapeutic needs.

Can Amitriptyline HCL 10 mg/ml Transdermal Gel be used for systemic treatment?

This formulation is more for targeted local treatment rather than systemic use. Consult your healthcare provider if you have systemic symptoms or require broader treatment.

Should I wash my hands after applying Amitriptyline HCL 10 mg/ml Transdermal Gel?

Yes, you should wash your hands after application to reduce the chances of the medication being accidentally transferred to other parts of your body or ingested.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCL 10 mg/ml Transdermal Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)