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Apomorphine HCl 15 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release medication for systemic absorption. This formulation is primarily used in the management of Parkinson's disease, providing relief from motor fluctuations and "off" episodes by stimulating dopamine receptors. It offers an alternative route of administration for patients who may have difficulty with oral medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Apomorphine Hydrochloride 15 mg Rectal Suppository is a compounded medication formulated to provide an alternative route of administration for apomorphine. Apomorphine is a non-ergoline dopamine agonist that stimulates dopamine receptors in the brain, which is particularly beneficial in managing symptoms of Parkinson's disease. It is primarily used to treat "off" episodes—periods of decreased mobility and increased symptoms in patients with advanced Parkinson's disease.
The rectal suppository form offers a viable option for patients who may have difficulty with oral medications or subcutaneous injections. By inserting the suppository into the rectum, the medication dissolves and is absorbed through the rectal mucosa, entering the bloodstream to exert its therapeutic effects. This route can be advantageous for patients experiencing gastrointestinal issues that impede oral absorption or for those who cannot tolerate injections.
For prescribers, this compounded formulation allows for individualized dosing to meet specific patient needs. It is essential to monitor patients closely when initiating therapy with apomorphine rectal suppositories, adjusting the dose as necessary based on the clinical response and tolerability. Careful consideration should be given to the patient's overall medical condition, concomitant medications, and potential for
Apomorphine HCl 15 mg rectal suppository is a formulation designed for insertion into the rectum, where it dissolves or melts to release the medication for systemic absorption. This formulation is primarily used in the management of Parkinson's disease, particularly for the treatment of "off" episodes, which are periods when other medications are not working well, leading to increased symptoms such as tremors, stiffness, and difficulty moving.
When considering the use of Apomorphine HCl rectal suppositories, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. Apomorphine is a dopamine agonist, and its interactions with other medications can influence its pharmacokinetics and pharmacodynamics.
Concomitant use of apomorphine with other central nervous system depressants, such as benzodiazepines, opioids, or alcohol, can enhance sedative effects, leading to increased drowsiness or dizziness. Patients should be advised to avoid or limit the use of such substances while using apomorphine suppositories.
Apomorphine may also interact with medications that affect blood pressure. It can cause orthostatic hypotension, and when used with antihypertensive drugs, there is a risk of additive hypotensive effects. Patients should be monitored for signs of low blood pressure, such as dizziness or fainting, especially when standing up from a sitting or lying position.
Additionally, apomorphine is contraindicated with 5HT3 antagonists, such as ondansetron, due to the risk of profound hypotension and loss of consciousness. Patients and prescribers should ensure that these medications are not used concurrently.
There is also a potential interaction with dopamine antagonists, such as antipsychotics, which may reduce the effectiveness of apomorphine by blocking dopamine receptors. This can lead to a worsening of Parkinson's symptoms, and alternative treatments should be considered if possible.
Patients using apomorphine should be aware of the potential for interactions with other medications they may be taking, including over-the-counter drugs and supplements. It is important to inform healthcare providers of all medications being used to assess for possible interactions.
If you have any questions or concerns about the use of Apomorphine HCl 15 mg rectal suppositories and potential drug interactions, please reach out to us for further information and guidance.
Apomorphine HCl 15 mg Rectal Suppository is a specialized formulation designed to deliver the active pharmaceutical ingredient, apomorphine hydrochloride, directly into the rectal cavity. This solid dosage form is crafted to dissolve or melt upon insertion, allowing the medication to be absorbed through the rectal mucosa. The rectal route of administration is particularly advantageous for patients who may have difficulty swallowing oral medications or for those who require rapid onset of action due to its ability to bypass the gastrointestinal tract and first-pass metabolism in the liver.
Apomorphine is a non-selective dopamine agonist that primarily stimulates dopamine receptors in the brain. It is commonly used in the management of Parkinson's disease, a neurodegenerative disorder characterized by the depletion of dopamine in the brain, leading to symptoms such as tremors, rigidity, and bradykinesia. By activating dopamine receptors, apomorphine helps to restore the balance of neurotransmitters, thereby alleviating these motor symptoms and improving the quality of life for patients with Parkinson's disease.
The rectal suppository form of apomorphine HCl offers several benefits. It provides an alternative route of administration for patients who experience nausea or vomiting, which can be a side effect of oral medications or a symptom of the disease itself. Additionally, the rectal route can offer a more consistent absorption profile, potentially leading to more stable plasma concentrations and improved symptom control. This can be particularly beneficial during off periods or when oral administration is not feasible.
For prescribers, it is important to consider the individual needs of the patient when selecting this formulation. Factors such as the severity of symptoms, the patient's ability to tolerate other forms of medication, and the need for rapid symptom relief should be taken into account.
Patients using apomorphine HCl rectal suppositories should be instructed on the proper method of administration to ensure optimal absorption and efficacy. It is recommended to insert the suppository after a bowel movement to enhance absorption and reduce the likelihood of expulsion. Patients should also be advised to remain lying down for a few minutes after insertion to facilitate the dissolution and absorption of the medication.
If you have any questions about this formulation or its use in treating Parkinson's disease, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your treatment options.
Apomorphine HCl 15 mg Rectal Suppository is used to treat certain medical conditions by delivering medication directly to the rectum, where it can be absorbed for local or systemic effects. It is often used in the management of Parkinson's disease to help control symptoms such as muscle stiffness and tremors.
To use the suppository, gently insert it into the rectum, typically after a bowel movement. It is important to follow the instructions provided by your healthcare provider or pharmacist for proper insertion and dosage.
A rectal suppository is a solid dosage form that dissolves or melts in the rectum, allowing the medication to be absorbed into the bloodstream for local or systemic effects.
If you miss a dose of Apomorphine HCl 15 mg Rectal Suppository, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Common side effects may include nausea, dizziness, or irritation at the site of insertion. If you experience severe side effects or an allergic reaction, seek medical attention immediately.
Before using this suppository, inform your healthcare provider about all other medications you are taking, as there may be potential interactions. Your provider can advise you on the safe use of this medication with others.
Store the suppositories in a cool, dry place away from direct sunlight and moisture. Keep them out of reach of children and pets.
Ensure you follow the prescribed dosage and instructions. Avoid using alcohol or other sedatives while on this medication, as they may increase the risk of side effects. Discuss any medical conditions or allergies with your healthcare provider before use.
If you are pregnant or breastfeeding, consult your healthcare provider before using this medication to understand the potential risks and benefits.
If you experience severe side effects such as difficulty breathing, severe dizziness, or an allergic reaction, seek immediate medical attention. Contact your healthcare provider for guidance on managing any adverse effects.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
