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Apomorphine Hydrochloride is a dopamine agonist that Bayview compounds to a prescriber's order.
Apomorphine Hydrochloride is a non-ergoline dopamine agonist. Apomorphine injection is FDA-approved for the acute, intermittent treatment of hypomobility "off" episodes in patients with advanced Parkinson's disease.[1] Its effect is thought to result from stimulation of post-synaptic dopamine D2-type receptors in the brain.[1]
The FDA-approved injection is given subcutaneously, with peak blood levels reached 10 to 60 minutes after a dose, and it is used on an as-needed basis for off episodes.[1]
Apomorphine has also been studied in a sublingual form for erectile dysfunction, based on its central dopaminergic activity.[2] This use is not FDA-approved in the United States and is off-label.[2]
Prescribers should be aware of the side effect profile of apomorphine, which includes nausea and vomiting, yawning, drowsiness, dizziness, and orthostatic (postural) hypotension.[1] The injection label recommends starting the antiemetic trimethobenzamide before the first dose, and it contraindicates use with 5HT3 antagonist antiemetics such as ondansetron and granisetron because of profound hypotension and loss of consciousness.[1] Careful titration and monitoring are essential.[1]
Bayview compounds apomorphine sublingual troches on a prescriber's order.
Compounded at Bayview
Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.
For prescribers
Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.
Small lozenges of apomorphine, a dopamine agonist, that dissolve under the tongue, prepared by Bayview at 2 mg or 3 mg, plus a 3 mg/mL solution for the same route. No low-dose sublingual apomorphine is manufactured in the United States, so it is compounded to a prescriber's order. It is not FDA-approved, its use for erectile dysfunction is off-label, and a prescription is required.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
