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This compounded formulation combines Benztropine Mesylate, Dexamethasone, Diphenhydramine HCl, Haloperidol, Lorazepam, and Metoclopramide HCl into a suppository form. It is designed for insertion into a body cavity, typically the rectum, where it dissolves or melts to release the medication for local or systemic absorption.
This formulation is used to manage and treat a variety of conditions, including nausea, vomiting, anxiety, and symptoms associated with Parkinson's disease. It also addresses allergic reactions and provides relief from certain psychiatric symptoms.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This compounded suppository formulation contains a combination of Benztropine Mesylate, Dexamethasone, Diphenhydramine HCl, Haloperidol, Lorazepam, and Metoclopramide HCl. Each of these active ingredients has its own pharmacological profile and potential for drug interactions, which must be carefully considered by both patients and prescribers.
Benztropine Mesylate is an anticholinergic agent that can interact with other medications possessing anticholinergic properties, potentially leading to additive effects such as dry mouth, constipation, urinary retention, and confusion. Caution is advised when used concurrently with other anticholinergics or medications that can exacerbate these side effects.
Dexamethasone, a corticosteroid, can interact with a wide range of medications. It may enhance the effects of anticoagulants, leading to an increased risk of bleeding. Concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of gastrointestinal ulcers. Dexamethasone can also reduce the efficacy of vaccines and may interact with medications that affect blood glucose levels, necessitating careful monitoring in diabetic patients.
Diphenhydramine HCl, an antihistamine with sedative properties, can potentiate the sedative effects of central nervous system depressants such as alcohol, benzodiazepines, and opioids. It may also interact with monoamine oxidase inhibitors (MAOIs), leading to increased anticholinergic side effects and potential hypertensive crisis.
Haloperidol, an antipsychotic, can interact with medications that prolong the QT interval, increasing the risk of serious cardiac arrhythmias. It may also interact with other central nervous system depressants, leading to enhanced sedation and respiratory depression. Additionally, haloperidol can affect the metabolism of other drugs metabolized by the cytochrome P450 system, necessitating dose adjustments.
Lorazepam, a benzodiazepine, can have additive effects with other CNS depressants, increasing the risk of sedation, respiratory depression, and hypotension. Caution is advised when used with alcohol, opioids, or other sedative medications. Lorazepam may also interact with medications that inhibit or induce hepatic enzymes, affecting its clearance and efficacy.
Metoclopramide HCl, a prokinetic agent, can interact with medications that affect dopamine pathways, such as antipsychotics, leading to an increased risk of extrapyramidal symptoms. It may also enhance the effects of CNS depressants and interact with medications that prolong the QT interval. Additionally, metoclopramide can affect the absorption of other orally administered drugs by altering gastrointestinal motility.
Given the complexity of this formulation and the potential for significant drug interactions, it is crucial for prescribers to thoroughly review a patient's medication history and consider any potential interactions before prescribing this compounded suppository. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements. If you have any questions or concerns about this formulation or its interactions, please reach out to us for further assistance.
This compounded formulation combines several active pharmaceutical ingredients into a suppository form, designed for insertion into a body cavity such as the rectum. Upon insertion, the suppository dissolves or melts, allowing the active ingredients to be absorbed either locally or systemically, depending on the intended therapeutic effect. This method of administration can be particularly beneficial for patients who have difficulty swallowing oral medications or require rapid onset of action.
Benztropine Mesylate is an anticholinergic agent that works by blocking certain neurotransmitters in the brain, which helps to reduce symptoms of muscle stiffness, tremors, and spasms. It is often used in the management of Parkinson's disease and drug-induced extrapyramidal symptoms. By including Benztropine Mesylate in this formulation, the suppository can help alleviate these symptoms, providing relief to patients who may experience discomfort or impaired mobility.
Dexamethasone is a corticosteroid that reduces inflammation by suppressing the immune response. In this formulation, Dexamethasone can help manage inflammatory conditions, providing relief from pain and swelling, and improving overall patient comfort.
Diphenhydramine HCl is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is commonly used to relieve symptoms of allergy, hay fever, and the common cold. Additionally, Diphenhydramine has sedative properties, which can help in managing symptoms of anxiety and insomnia, contributing to the overall calming effect of the formulation.
Haloperidol is an antipsychotic medication that alters the effects of chemicals in the brain. It is used to treat a variety of psychiatric disorders, including schizophrenia and acute psychosis. By including Haloperidol, this suppository formulation can help stabilize mood and reduce symptoms of psychosis, providing a more balanced mental state for the patient.
Lorazepam is a benzodiazepine that enhances the effects of a neurotransmitter called GABA, which has calming effects on the brain and nerves. In this formulation, Lorazepam contributes to the anxiolytic and sedative effects, helping to calm the patient and reduce anxiety-related symptoms.
Metoclopramide HCl is a prokinetic agent that increases the movements or contractions of the stomach and intestines. It is used to treat nausea and vomiting, as well as to facilitate gastric emptying in patients with delayed stomach emptying. By including Metoclopramide, this suppository can effectively manage gastrointestinal symptoms, improving patient comfort and preventing complications associated with nausea and vomiting.
This combination of medications in a suppository form allows for a multifaceted approach to treatment, addressing a range of symptoms and conditions simultaneously. The rectal administration ensures that the medications are absorbed efficiently, bypassing the gastrointestinal tract and reducing the risk of gastrointestinal side effects. This can be particularly advantageous for patients who are unable to take oral medications or require a rapid therapeutic effect.
If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the best possible outcomes for your patients.
This compounded formulation is designed to deliver a combination of medications for various therapeutic effects, including anticholinergic, anti-inflammatory, antihistamine, antipsychotic, anxiolytic, and antiemetic actions. It is used to manage symptoms that may require these combined effects.
These suppositories should be inserted into the rectum or vagina, depending on your healthcare provider's instructions. Ensure your hands are clean before handling the suppository, and follow the specific insertion instructions provided by your healthcare provider or pharmacist.
The frequency of use will depend on your specific medical condition and the advice of your healthcare provider. It is important to follow their instructions carefully to avoid overuse or potential side effects.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Possible side effects may include drowsiness, dizziness, dry mouth, constipation, blurred vision, or urinary retention. If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately.
You should consult your healthcare provider before using this formulation if you are pregnant or breastfeeding. They will assess the potential risks and benefits based on your specific situation.
Store the suppositories in a cool, dry place away from direct sunlight and heat. Follow any additional storage instructions provided by your pharmacist or on the packaging.
Before using this formulation with other medications, consult your healthcare provider or pharmacist. They will help you understand potential interactions and ensure safe use of all your medications.
If you experience severe side effects, such as difficulty breathing, severe dizziness, or swelling, seek immediate medical attention. Contact your healthcare provider for guidance on managing any adverse reactions.
The suitability of this formulation for children depends on the specific medical condition and the advice of a healthcare provider. It is important to follow their guidance and not use this medication in children without professional advice.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
