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This compounded formulation of Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg is prepared as a suppository, a solid dosage form designed for insertion into a body cavity, typically the rectum, where it dissolves or melts to release medication for local or systemic absorption.
This combination is used to manage and treat symptoms associated with nausea, vomiting, and inflammation, often related to chemotherapy-induced nausea and vomiting (CINV), postoperative nausea and vomiting (PONV), and other conditions requiring antiemetic and anti-inflammatory therapy.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This compounded suppository combines Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg to provide a comprehensive approach to managing severe nausea and vomiting. Designed for rectal administration, this formulation allows for absorption when oral intake is compromised due to persistent emesis or when patients are unable to swallow medications.
Dexamethasone, a potent corticosteroid, contributes anti-inflammatory and antiemetic effects, particularly beneficial in chemotherapy-induced nausea and vomiting (CINV) and in palliative care settings. Its ability to reduce inflammation and inhibit prostaglandin synthesis helps alleviate symptoms associated with certain medical conditions.
Diphenhydramine HCl is an antihistamine that provides antiemetic properties by blocking H1 receptors in the brain's vomiting center. It also offers sedative effects, which can help reduce discomfort and anxiety associated with severe nausea.
Haloperidol, an antipsychotic agent with antiemetic effects, works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain, effectively reducing nausea and vomiting. Its inclusion in this formulation enhances the antiemetic coverage, especially in patients unresponsive to other treatments.
Metoclopramide HCl serves both as an antiemetic and a prokinetic agent. It increases gastrointestinal motility and accelerates gastric emptying, which helps in reducing nausea by decreasing gastric stasis. Additionally, it blocks dopamine receptors in the CTZ, complementing the action of Haloperidol.
The combination of these four medications targets multiple pathways involved in nausea and vomiting, providing a synergistic effect that enhances overall efficacy. This makes the suppository particularly useful for patients undergoing chemotherapy, experiencing postoperative nausea, or those in palliative care with refractory symptoms.
For prescribers, this compounded formulation offers a customizable treatment option for patients who require multi-faceted antiemetic therapy but cannot tolerate oral medications. The rectal route ensures medication delivery even when gastrointestinal absorption is compromised. Dosages can be adjusted according to patient-specific needs and tolerability.
Patients using this suppository may experience relief from severe nausea and vomiting, improving their quality of life and allowing for better management of their underlying condition. It is important to follow administration instructions carefully and report any side effects to your healthcare provider.
If you have any questions, please reach out to us.
This compounded formulation of Dexamethasone 10 mg, Diphenhydramine HCl 25 mg, Haloperidol 1 mg, and Metoclopramide HCl 20 mg in suppository form is designed to provide therapeutic benefits through local or systemic absorption when inserted into a body cavity such as the rectum. Each active ingredient in this formulation has the potential to interact with other medications, which is crucial for both patients and prescribers to consider when using this treatment.
Dexamethasone, a corticosteroid, can interact with a wide range of medications. It may enhance the effects of anticoagulants, increasing the risk of bleeding. Concurrent use with nonsteroidal anti-inflammatory drugs (NSAIDs) can heighten the risk of gastrointestinal ulcers. Dexamethasone can also reduce the effectiveness of vaccines and may interact with medications that affect liver enzymes, such as certain antifungals and antibiotics, potentially altering their metabolism and efficacy.
Diphenhydramine HCl, an antihistamine, can cause sedation and should be used cautiously with other central nervous system depressants, such as benzodiazepines, opioids, and alcohol, as it may enhance their sedative effects. It can also interact with monoamine oxidase inhibitors (MAOIs), potentially leading to increased anticholinergic side effects. Patients with glaucoma, urinary retention, or prostate hypertrophy should use diphenhydramine with caution due to its anticholinergic properties.
Haloperidol, an antipsychotic, has a known interaction profile that includes the potential for QT interval prolongation. It should be used cautiously with other medications that can prolong the QT interval, such as certain antiarrhythmics, antibiotics, and antidepressants, as this can increase the risk of serious cardiac arrhythmias. Haloperidol can also interact with medications that affect the cytochrome P450 enzyme system, particularly CYP3A4 and CYP2D6 inhibitors, which can alter its metabolism and increase the risk of side effects.
Metoclopramide HCl, a prokinetic agent, can interact with medications that affect dopamine pathways, such as antipsychotics, potentially increasing the risk of extrapyramidal symptoms. It can also enhance the sedative effects of CNS depressants and may interact with medications that affect gastrointestinal motility, such as anticholinergics, which can counteract its prokinetic effects. Additionally, metoclopramide can alter the absorption of other orally administered drugs by changing gastrointestinal transit time.
Given the complexity of potential drug interactions with this compounded formulation, it is essential for prescribers to thoroughly review a patient's current medication regimen and medical history before initiating treatment. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to avoid adverse interactions. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.
This compounded formulation combines Dexamethasone, Diphenhydramine HCl, Haloperidol, and Metoclopramide HCl into a suppository form, designed for insertion into a body cavity such as the rectum. Upon insertion, the suppository dissolves or melts, allowing the active ingredients to be absorbed either locally or systemically, depending on the intended therapeutic effect. This method of administration can be particularly beneficial for patients who have difficulty swallowing oral medications or require rapid absorption through the rectal mucosa.
Dexamethasone is a potent corticosteroid that works by reducing inflammation and suppressing the immune response. It is often used to treat conditions involving inflammation and immune system overactivity. In this formulation, Dexamethasone can help manage symptoms associated with inflammatory diseases, providing relief from pain and swelling.
Diphenhydramine HCl is an antihistamine that blocks the action of histamine, a substance in the body that causes allergic symptoms. It is commonly used to relieve symptoms of allergy, hay fever, and the common cold, such as itching, sneezing, and runny nose. In this suppository form, Diphenhydramine can also help alleviate nausea and vomiting, as it has antiemetic properties.
Haloperidol is an antipsychotic medication that works by altering the effects of chemicals in the brain. It is used to treat a variety of psychiatric disorders, including schizophrenia and acute psychosis. In this formulation, Haloperidol can help manage symptoms of agitation and severe nausea, providing a calming effect and reducing the urge to vomit.
Metoclopramide HCl is a prokinetic agent that enhances gastrointestinal motility and accelerates gastric emptying. It is used to treat nausea and vomiting, as well as conditions like gastroparesis. By promoting the movement of the stomach and intestines, Metoclopramide helps reduce symptoms of nausea and vomiting, making it a valuable component of this combination therapy.
The combination of these four active ingredients in a suppository form allows for a multifaceted approach to treating conditions that involve inflammation, allergic reactions, psychiatric symptoms, and gastrointestinal disturbances. The rectal administration ensures that the medications are absorbed efficiently, bypassing the gastrointestinal tract and reducing the risk of degradation by stomach acids. This can lead to a more rapid onset of action and improved patient compliance, especially in those who are unable to take oral medications.
If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need.
This compounded formulation is designed to provide a combination of medications that can help manage symptoms such as inflammation, allergic reactions, nausea, vomiting, and certain psychiatric conditions. The suppository form allows for local or systemic absorption, which can be beneficial for patients who cannot take oral medications.
These suppositories should be stored in a cool, dry place, away from direct sunlight and heat. It is important to keep them out of reach of children and pets. Follow any specific storage instructions provided by your pharmacist or healthcare provider.
To use the suppository, wash your hands thoroughly, remove the wrapper, and gently insert the suppository into the rectum or vagina, depending on your healthcare provider's instructions. It is often easier to insert the suppository while lying down. Follow any additional instructions provided by your healthcare provider.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. Consult your healthcare provider if you have any concerns.
Possible side effects may include dizziness, drowsiness, dry mouth, constipation, or irritation at the site of insertion. If you experience severe side effects such as difficulty breathing, severe allergic reactions, or unusual changes in mood or behavior, seek medical attention immediately.
Before using this medication, consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. They will assess the potential risks and benefits and determine if this medication is appropriate for you.
The time it takes for the suppository to dissolve and take effect can vary depending on individual factors and the specific condition being treated. Generally, it may take about 15 to 60 minutes for the medication to be absorbed and start working. Consult your healthcare provider for more specific information.
Before using this formulation, inform your healthcare provider about all other medications you are taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with the components of this formulation, potentially affecting its efficacy or increasing the risk of side effects.
If you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention. Discontinue use of the suppository and inform your healthcare provider about the reaction.
The safety of long-term use of this compounded formulation depends on the specific medical condition being treated and individual patient factors. Your healthcare provider will determine the appropriate duration of treatment based on your needs and monitor for any potential side effects or complications.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
