Check out our most popular compounded medications! Get Started
The Estradiol 0.2 mg/ml/Progesterone 20 mg/ml Topical Cream is a semisolid preparation that combines two active ingredients, estradiol and progesterone, in a base suitable for topical application. This cream is dispensed in a pump mechanism, which allows for convenient and controlled dosing. The formulation is designed to be applied directly to the skin, where it can provide localized treatment or facilitate the systemic absorption of the hormones.
Estradiol is a form of estrogen, a female hormone involved in the regulation of various processes in the body. Progesterone is another hormone that plays a key role in the menstrual cycle and in maintaining the early stages of pregnancy. Together, these hormones are used to treat certain disease states such as menopausal symptoms, including hot flashes and vaginal dryness, and to prevent osteoporosis. Additionally, this formulation may be prescribed as part of hormone replacement therapy (HRT) for individuals with low hormone levels due to menopause or other conditions.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Estradiol 0.2 mg/ml/Progesterone 20 mg/ml Topical Cream is a compounded medication specifically designed to deliver a combination of estrogen and progesterone hormones through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, controlled, and consistent application. The cream is intended for localized treatment, with the active ingredients being absorbed through the skin to exert their effects.
Estradiol, a form of estrogen, is a hormone that plays a critical role in the regulation of the menstrual cycle and reproductive system in women. It is also involved in maintaining the health of other body tissues, such as bone. Progesterone is another hormone essential for regulating the menstrual cycle and is crucial for maintaining pregnancies. In combination, these hormones can be used to address various disease states, primarily in hormone replacement therapy (HRT).
This particular formulation is often prescribed for the management of menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. It may also be used in cases of estrogen dominance, where the balance between estrogen and progesterone is disrupted. The topical route of administration is chosen to minimize first-pass metabolism by the liver and to provide a more direct therapeutic effect with potentially fewer systemic side effects compared to oral forms.
For patients, it is important to understand that this medication should be used as directed by a healthcare provider, and it is essential to follow the application instructions to ensure proper dosing. Patients should be aware of potential side effects, which may include skin irritation at the application site, as well as systemic effects such as headaches, breast tenderness, or gastrointestinal disturbances. It is also crucial for patients to report any history of hormone-sensitive conditions, such as breast or uterine cancer, as hormone therapy may not be appropriate in these cases.
Prescribers should consider individual patient needs, hormone levels, and risk factors when determining the suitability of this formulation. Monitoring hormone levels and adjusting the dose may be necessary to achieve optimal therapeutic outcomes while minimizing adverse effects. Additionally, prescribers should counsel patients on the importance of regular follow-ups to monitor the efficacy and safety of the treatment.
If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing support and guidance to ensure the safe and appropriate use of compounded medications.
The estradiol and progesterone topical cream is a hormone replacement therapy used to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and bone loss prevention. When considering drug interactions, it is important to note that both estradiol and progesterone can interact with a variety of medications and substances. This section provides an overview of potential interactions, but it is not exhaustive. For specific concerns or more detailed information, please reach out to us at Bayview Pharmacy.
Estradiol, a form of estrogen, can be affected by substances that induce or inhibit cytochrome P450 enzymes, particularly CYP3A4. Enzyme inducers such as carbamazepine, phenytoin, rifampicin, and St. John's Wort may reduce the plasma concentrations of estradiol, potentially decreasing its efficacy. Conversely, inhibitors of CYP3A4 like ketoconazole, itraconazole, and grapefruit juice may increase estradiol levels, raising the risk of side effects. Additionally, concurrent use of other hormonal therapies, including certain contraceptives, may alter the effects of estradiol and should be approached with caution.
Progesterone can also interact with enzyme inducers and inhibitors, as it is metabolized by CYP3A4. Similar to estradiol, the use of CYP3A4 inducers may decrease progesterone levels, while inhibitors can increase them. Patients should be advised to avoid known inducers or inhibitors of this enzyme where possible, or to consult with a healthcare provider for monitoring and potential dose adjustments.
Both estradiol and progesterone may also interact with anticoagulants like warfarin. Hormone replacement therapy can either increase or decrease the anticoagulant effect, necessitating close monitoring of coagulation parameters and possible adjustment of the anticoagulant dose. Additionally, the use of these hormones may affect glucose metabolism, and diabetic patients may require adjustments in their antidiabetic medication.
It is also important to consider the potential for additive effects when used with other medications that have similar side effects, such as other hormonal therapies or corticosteroids. Patients should be counseled on the signs and symptoms of hormone excess and advised to report any unusual symptoms to their healthcare provider.
Patients should be instructed to inform their healthcare providers of all medications, supplements, and herbal products they are taking to ensure safe and appropriate use of this topical cream. If you have any questions or require further clarification on drug interactions with this estradiol/progesterone formulation, please do not hesitate to reach out to us at Bayview Pharmacy for personalized advice and support.
The Estradiol 0.2 mg/ml/Progesterone 20 mg/ml Topical Cream is a hormone replacement therapy (HRT) designed to deliver bioidentical hormones directly through the skin into the bloodstream. Estradiol and progesterone, the active ingredients in this formulation, are identical in molecular structure to the hormones naturally produced by the ovaries. This topical cream is compounded in a semisolid base that allows for the hormones to be absorbed through the skin, providing a convenient alternative to oral or injectable forms of HRT.
Estradiol is a form of estrogen, a female hormone involved in many processes in the body. It is primarily used to treat symptoms of menopause such as hot flashes, vaginal dryness, burning, and irritation. Additionally, it can help prevent osteoporosis in postmenopausal women. Progesterone is another hormone that plays a vital role in regulating menstruation and maintaining the early stages of pregnancy. In combination, these hormones can help restore hormonal balance in women who are experiencing a deficiency or imbalance of these hormones due to menopause or other medical conditions.
The cream is dispensed in a pump mechanism, which is designed to deliver a controlled dose of the medication with each pump. This ensures consistent dosing and helps to prevent the variability that can occur with manually measured applications. The pump also minimizes the risk of contamination that can occur with jar packaging. Patients are instructed to apply the cream to clean, dry skin, typically on the arms, thighs, or abdomen. The area of application should be rotated to avoid skin irritation.
Upon application, the active ingredients are absorbed through the skin and enter the capillary blood. The transdermal route bypasses the first-pass metabolism in the liver, which can occur with oral medications. This may result in fewer side effects and improved efficacy of the hormones. The steady absorption through the skin can also provide more stable hormone levels, avoiding the peaks and troughs often associated with oral or injectable forms.
It is important for patients and prescribers to understand that hormone replacement therapy with estradiol and progesterone should be tailored to an individual's needs and should be used at the lowest effective dose for the shortest duration consistent with treatment goals. Regular monitoring and follow-up with a healthcare provider are essential to ensure the safety and effectiveness of the treatment. If you have any questions or require further information about this formulation and its use in treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide support and guidance.
This topical cream is a hormone replacement therapy used to help manage menopausal symptoms such as hot flashes, vaginal dryness, and bone loss prevention by supplying the hormones estrogen (as estradiol) and progesterone through the skin.
To use the cream, press the pump to dispense the prescribed amount of medication, and then apply it to clean, dry skin as directed by your healthcare provider. The usual application areas are the arms, legs, or other areas as specified by your physician.
The frequency of use will be determined by your doctor, based on your specific condition and treatment goals. Follow the prescribing doctor's instructions closely and do not alter the dose without consulting them.
No, you should apply the cream only to the areas of the skin that your healthcare provider has approved. Absorption can vary depending on the site of application, and some areas may be more sensitive to the hormones.
If you forget to apply a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
As with all medications, there can be side effects. Some common side effects include skin irritation at the site of application, headaches, breast tenderness, and mood swings. Contact your doctor if you experience any severe or persistent side effects.
Store the cream at room temperature, away from direct sunlight and heat. Do not freeze. Keep the container closed when not in use.
It is possible for this cream to interact with other medications, supplements, or herbal products you may be taking. Be sure to discuss all your current medications with your doctor to avoid potential interactions.
This medication should not be used during pregnancy or while breastfeeding. If you become pregnant or plan to breastfeed while using this medication, contact your doctor immediately for guidance.
Avoid applying the cream to broken skin or near the eyes. Also, do not allow others to come into contact with the area of skin where the hormone cream was applied. Additionally, you may be advised to avoid certain activities such as swimming or bathing immediately after application. Check with your doctor for further advice.
The time it takes for the medication to take effect can vary. Some individuals may notice improvements in symptoms within a few weeks, while for others it may take longer. Continue to use the medication as directed and discuss any concerns with your healthcare provider.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
