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Active pharmaceutical ingredient

Estradiol

Estradiol is a naturally occurring estrogen (the main estrogen made by the ovaries) that Bayview compounds to a prescriber's order.

Compounded to order
Prescription required

About this ingredient

Estradiol is an estrogenic hormone used in hormone therapy and other applications. It is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.[2] It is the most potent and abundant estrogen during a woman's reproductive years and is crucial in regulating the menstrual cycle as well as the cardiovascular, neurologic, and skeletal systems.[1] Estradiol is indicated for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy associated with menopause.[2]

Other labeled uses include the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, the prevention of postmenopausal osteoporosis, and palliative treatment of certain metastatic breast cancers and advanced prostate cancer.[2]

Circulating estrogens are bound to sex hormone binding globulin and albumin, and their metabolic interconversions take place mainly in the liver.[2] Estradiol, estrone, and estriol are excreted in the urine along with glucuronide and sulfate conjugates.[2]

Prescribing estradiol requires careful consideration of patient-specific factors such as age, medical history, and concurrent medications. Estrogen therapy carries boxed warnings for endometrial cancer, cardiovascular disorders including stroke and blood clots, breast cancer, and probable dementia, and estrogens should be used at the lowest effective dose and for the shortest duration consistent with treatment goals.[1][2] Bayview Pharmacy compounds estradiol preparations on a prescriber's order.

Compounded at Bayview

How we prepare this ingredient

Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.

For prescribers

Full formulary with this ingredient

Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.

Common questions

Frequently asked questions

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Related

Related active ingredients

Other salt forms of this molecule, and ingredients commonly compounded alongside it.

Important information

This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.

Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Talk to a compounding pharmacist

Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.