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The Estradiol 0.25 mg/Estriol 0.25 mg/Progesterone 20 mg/gm Topical Cream is a compounded semisolid preparation that combines two forms of estrogen with progesterone. This cream is dispensed in a pump mechanism, which allows for precise dosing and ease of application to the skin. The formulation is designed for localized treatment and can facilitate the absorption of the active ingredients through the skin.
This topical cream is primarily used in the management of menopausal symptoms, such as hot flashes, night sweats, vaginal dryness, and mood swings. It may also be utilized in hormone replacement therapy (HRT) for women with low hormone levels or in certain cases of hormonal imbalance. The combination of estradiol, estriol, and progesterone aims to mimic the natural hormone levels in the body, providing relief from the aforementioned disease states while minimizing systemic side effects.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Estradiol 0.25 mg/Estriol 0.25 mg/Progesterone 20 mg/gm Topical Cream is a compounded medication that combines the estrogen hormones estradiol and estriol with the progestogen hormone progesterone in a topical cream base. This formulation is specifically designed to deliver a consistent dose of hormones directly through the skin, which can help to minimize systemic side effects associated with oral hormone therapies. The cream is dispensed in a pump mechanism, which allows for precise dosing and ease of application. This is particularly beneficial for patients who require a tailored approach to hormone replacement therapy (HRT).
The combination of estradiol and estriol in this cream is intended to address symptoms of estrogen deficiency, which may occur during menopause or as a result of certain medical conditions. Estradiol is the most potent form of estrogen and can help alleviate hot flashes, vaginal dryness, and bone loss. Estriol, a weaker estrogen, is often used in combination with estradiol to provide a balanced estrogenic effect with potentially fewer side effects. Progesterone is included in the formulation to counterbalance the effects of estrogen on the endometrium, thereby reducing the risk of endometrial hyperplasia and cancer that can be associated with estrogen-only therapies.
This topical cream may be prescribed for the management of menopausal symptoms, such as vasomotor symptoms, urogenital atrophy, and osteoporosis prevention. It may also be used in certain cases of hormone imbalance or as part of a broader hormone replacement strategy. The topical route of administration ensures that the hormones are absorbed directly into the bloodstream, bypassing the liver and potentially reducing the risk of liver-related side effects.
It is important for patients and prescribers to understand that this is a compounded medication and should be used under the guidance of a healthcare professional with expertise in hormone therapy. The specific dose and regimen will be individualized based on the patient's needs, symptoms, and hormone levels. Regular monitoring and follow-up with the healthcare provider are essential to ensure the effectiveness of the treatment and to make any necessary adjustments.
For any questions or concerns regarding this formulation, or to discuss individualized treatment options, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing high-quality, customized medications to meet the unique needs of each patient.
The formulation containing Estradiol 0.25 mg, Estriol 0.25 mg, and Progesterone 20 mg/gm as a topical cream is designed to deliver hormones directly through the skin. This method of delivery can help in the management of menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention. It may also be used in hormone replacement therapy for individuals with hormonal imbalances. However, it is important to consider potential drug interactions when using this formulation.
Firstly, patients should be aware that the use of this hormone cream in conjunction with other hormonal therapies, including oral contraceptives or other forms of hormone replacement therapy, may alter the effects of the hormones and increase the risk of side effects such as thromboembolic disorders, breast tenderness, or bleeding irregularities. It is crucial to inform the prescriber of all current medications to avoid such interactions.
Additionally, certain medications can affect the metabolism of hormones in this formulation. For example, some anticonvulsants and antibiotics may increase the breakdown of hormones, potentially reducing the effectiveness of the cream. Conversely, medications such as ketoconazole, itraconazole, and other CYP3A4 inhibitors can decrease the metabolism of hormones, leading to increased levels and a higher risk of side effects.
Patients using thyroid hormone replacement therapy should also be monitored, as estrogen-containing products can increase thyroid-binding globulin (TBG) levels, which may alter thyroid function tests. Adjustments to thyroid medication dosages may be necessary.
Progesterone in the formulation can be affected by the use of drugs that induce hepatic enzymes, such as rifampin or St. John's Wort, which may decrease its effectiveness. Conversely, drugs that inhibit hepatic enzymes, such as erythromycin or grapefruit juice, may increase progesterone levels and enhance its effects and side effects.
It is also important to note that smoking can increase the clearance of estrogen and may reduce its therapeutic effects. Patients are advised to avoid smoking while using this formulation.
Lastly, the use of this topical cream may affect laboratory tests, including tests for coagulation factors, lipids, glucose tolerance, and binding proteins. It is important to inform healthcare providers about the use of this formulation before undergoing any lab tests.
Due to the complexity of hormone interactions and individual patient variability, prescribers should closely monitor patients for any adverse effects or unexpected responses to the therapy. Dose adjustments may be necessary based on clinical response and side effect profile. If you have any questions or require further information regarding this formulation and its interactions, please reach out to us at Bayview Pharmacy for professional advice and support.
The Estradiol 0.25 mg/Estriol 0.25 mg/Progesterone 20 mg/gm Topical Cream is a compounded medication that combines three hormones commonly used in hormone replacement therapy (HRT). Estradiol and estriol are forms of estrogen, a hormone that regulates many processes in the female body, while progesterone is another hormone that plays a key role in the menstrual cycle and in maintaining the early stages of pregnancy.
This topical cream is formulated to deliver a consistent dose of hormones directly through the skin, where they are absorbed into the bloodstream. The use of a semisolid cream base allows for the hormones to be evenly distributed and facilitates absorption. The cream is dispensed in a pump mechanism, which is designed to provide a controlled amount of the product with each use, ensuring accurate dosing and ease of application.
When applied to the skin, the active ingredients in the cream are absorbed into the local tissue and then into the systemic circulation. Estradiol and estriol can help alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and bone loss, by supplementing the body's natural estrogen levels, which decrease during menopause. Progesterone is used in combination with estrogen to prevent the overgrowth of the lining of the uterus (endometrial hyperplasia) that can occur with estrogen therapy alone. It also contributes to the overall balance of hormones in the body and can help improve sleep quality and mood.
This hormone combination can be particularly beneficial for perimenopausal and postmenopausal women who are experiencing symptoms of estrogen deficiency and require hormone replacement therapy. The topical route of administration can be advantageous for those who prefer not to take oral medications or for those who may have contraindications to oral estrogens, such as a history of thromboembolic events or liver dysfunction.
It is important to note that hormone replacement therapy should be tailored to the individual patient's needs and should be used at the lowest effective dose for the shortest duration necessary to achieve treatment goals. Regular follow-up with a healthcare provider is essential to monitor the therapy's effectiveness and to make any necessary adjustments.
If you have any questions about this formulation or how it can be used to treat specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the safe and appropriate use of this medication.
This compounded formulation of Estradiol, Estriol, and Progesterone is designed for hormonal replacement therapy. It is often prescribed for managing menopause symptoms, including hot flashes, night sweats, mood changes, and vaginal dryness. The combination of these hormones can also help in maintaining the health of the skin, bones and reproductive tissues.
Clean and dry the area of skin where the cream will be applied. Use the pump to dispense the prescribed amount of cream, then gently rub it into the skin until it is fully absorbed. Make sure to follow your physician’s instructions when determining the dosage and frequency of application.
It is important to apply the cream only to the areas of the skin as directed by your healthcare provider. Common application sites include the wrists, inner arms, thighs, or other areas as recommended by your doctor to ensure proper absorption of the hormones.
The number of pumps needed will depend on the dose prescribed by your healthcare provider. It is crucial to follow the dosing instructions provided to ensure you receive the proper amount of medication.
The frequency of application will vary according to your individual treatment plan, as decided by your healthcare provider. Typically, it may be applied once or twice daily, but be sure to follow the specific instructions given to you.
Like all medications, this cream can cause side effects, though not everyone will experience them. Possible side effects include skin irritation, redness or itching at the application site, hormonal variations, and more systemic symptoms such as weight changes, mood fluctuations, or changes in menstruation. If side effects persist or worsen, contact your healthcare provider.
It is best to allow the cream to fully absorb into your skin before applying any makeup or sunscreen. If you must apply other skincare products, wait a minimum of several minutes after this cream's application to reduce the risk of interaction or interference with the absorption of the hormones.
Store the hormonal cream at room temperature, away from direct sunlight and heat. Do not freeze the cream and keep it out of reach of children and pets.
If you forget to apply a dose of the topical cream, apply it as soon as you remember unless it is nearly time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
It is recommended to allow adequate time for the cream to absorb into the skin before showering or swimming. Typically, waiting at least one hour after application will ensure maximal absorption of the hormones.
This cream contains hormones that may not be safe for use during pregnancy. Always consult your healthcare provider before starting any new medication, especially during pregnancy or while breastfeeding.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
