Check out our most popular compounded medications! Get Started
The Estradiol 1 mg/Estriol 4 mg/Progesterone 75 mg/Testosterone 6 mg/ml Topical Cream is a compounded semisolid preparation that combines four hormone active ingredients. This cream is specifically formulated for transdermal delivery through a pump mechanism, which ensures a convenient, controlled, and consistent application to the skin. The combination of estradiol, estriol, progesterone, and testosterone in this cream is commonly used in hormone replacement therapy to address symptoms associated with menopause, such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. Additionally, it may be prescribed to treat hormonal imbalances in premenopausal women and as part of transgender hormone therapy. The topical route of administration targets localized treatment areas and facilitates the absorption of the hormones into the bloodstream, providing therapeutic effects while minimizing systemic side effects.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Estradiol 1 mg/Estriol 4 mg/Progesterone 75 mg/Testosterone 6 mg/ml Topical Cream is a compounded medication specifically designed to deliver a combination of hormones directly through the skin. This semisolid preparation is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The pump is calibrated to deliver a precise dose with each actuation, minimizing dosing errors and ensuring consistency in the amount of medication applied.
The formulation combines estradiol and estriol, both of which are forms of estrogen. Estradiol is the primary human estrogen and is essential for many processes in the body. Estriol is a weaker estrogen, often used in combination with other estrogens for its potential to alleviate menopausal symptoms with a lower risk of side effects. Progesterone is included to counterbalance the effects of estrogen and is essential for regulating the menstrual cycle and maintaining the early stages of pregnancy. Testosterone, although commonly recognized as a male hormone, plays a crucial role in female health as well, contributing to libido, bone density, and muscle strength.
This hormone combination cream is primarily used in hormone replacement therapy (HRT) for menopausal and perimenopausal women. It can help alleviate symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. Additionally, it may be prescribed to address hormone imbalances in women with conditions such as premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), or certain cases of infertility. The inclusion of testosterone in the formulation can be particularly beneficial for women experiencing a decrease in libido or other symptoms related to low testosterone levels.
It is important for both patients and prescribers to understand that this is a customized medication prepared in a compounding pharmacy. The dosages of each hormone can be adjusted to meet the specific needs of the patient, based on their symptoms and hormone levels.
As with any hormone replacement therapy, there are potential risks and side effects associated with the use of this topical cream. Patients should be counseled on the signs and symptoms of hormone excess or deficiency, and the importance of adhering to the prescribed dosing schedule. Prescribers should evaluate the risks and benefits of this therapy for each individual patient, considering factors such as personal and family medical history, and current health status.
If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing support and guidance to ensure the safe and appropriate use of compounded hormone therapies.
The formulation you have described is a compounded topical cream containing a combination of hormones: estradiol, estriol, progesterone, and testosterone. This type of hormone therapy can be used to treat various conditions, such as menopausal symptoms, hormonal imbalances, and certain cases of androgen deficiency. It is important to note that the use of this cream can lead to interactions with other medications, and these should be carefully considered before starting treatment.
One potential interaction is with blood thinners (anticoagulants) such as warfarin. Hormones like estrogen and progesterone can potentially alter the effects of anticoagulants, increasing the risk of bleeding or clotting. Patients on blood thinners should have their clotting status monitored closely when starting or adjusting hormone therapy. Additionally, certain medications metabolized by liver enzymes, particularly those in the cytochrome P450 family, may have altered effectiveness when used concurrently with hormones. This is because hormones can induce or inhibit these enzymes, affecting the metabolism of other drugs.
Thyroid hormone replacement therapy may also be affected by the use of this cream. Estrogens can increase thyroid-binding globulin levels, which may alter the amount of thyroid hormone that is free and active in the body. Patients on thyroid replacement therapy may require monitoring and potential dosage adjustments when initiating hormone therapy with this cream.
Patients using insulin or oral diabetes medications should be aware that progesterone and testosterone can affect glucose tolerance and insulin sensitivity. Blood glucose levels should be monitored, and diabetes medications may need to be adjusted accordingly. Additionally, patients with a history of hormone-sensitive cancers, such as breast or endometrial cancer, should use this cream with caution, as it may potentially stimulate the growth of these cancers.
It is also important to consider the potential for systemic absorption of these hormones, even though the cream is applied topically. This means that interactions typically associated with oral or systemic hormone therapies could potentially occur with this cream as well. Patients should inform their healthcare providers of all medications, supplements, and herbal products they are taking to ensure that any potential interactions can be assessed and managed.
Lastly, the use of this hormone cream may influence the effectiveness of certain laboratory tests. Hormone levels, liver function tests, and other blood parameters may be affected, and healthcare providers should interpret these tests with consideration of the hormone therapy.
Patients and prescribers are encouraged to discuss all current medications and health conditions before starting treatment with this formulation. If you have any questions or require further information, please reach out to us at Bayview Pharmacy for assistance.
The Estradiol 1 mg/Estriol 4 mg/Progesterone 75 mg/Testosterone 6 mg/ml Topical Cream is a compounded hormone replacement therapy designed to deliver a combination of hormones directly through the skin. This formulation is particularly used for managing symptoms associated with hormonal imbalances or deficiencies, such as those experienced during menopause or as part of gender-affirming hormone therapy.
The active ingredients in this cream work by supplementing the body's natural hormone levels. Estradiol and estriol are forms of estrogen, a hormone that regulates many processes in the body, including reproductive functions and the maintenance of bone density. Progesterone is another hormone that plays a key role in the menstrual cycle and in maintaining the early stages of pregnancy. Testosterone, while typically considered a male hormone, is also present in females and contributes to libido, bone density, and muscle strength.
When applied to the skin, the hormones in the cream are absorbed into the bloodstream. This method of delivery can be advantageous because it allows the hormones to bypass the liver initially, potentially reducing the risk of certain side effects and improving the hormonal balance in the body. The cream is formulated to ensure that the hormones are released consistently and absorbed effectively over time.
The pump mechanism of the cream's container is designed to dispense a measured dose with each pump, which helps to ensure that the patient receives the correct amount of medication with each application. The cream is typically applied to areas of the skin where it can be easily absorbed, such as the inner arms or thighs.
This hormone combination can be used to treat various disease states associated with hormonal deficiencies or imbalances. For example, in menopausal women, it can help alleviate symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. In gender-affirming therapy, it can aid in the development of secondary sexual characteristics in accordance with the individual's gender identity. Additionally, it may be used to address conditions like osteoporosis, where hormone supplementation can help improve bone density.
It is important to note that hormone replacement therapy should be tailored to the individual's specific needs and monitored regularly by a healthcare provider. The risks and benefits of hormone therapy must be weighed on a case-by-case basis. If you have any questions or require further information about this formulation and its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to both patients and prescribers considering this treatment option.
This compounded formulation is commonly prescribed to address hormone imbalances or deficiencies. It includes a combination of hormones – Estradiol, Estriol, Progesterone, and Testosterone – blended into a topical cream designed for patients who may need hormone replacement therapy to alleviate symptoms associated with menopause, perimenopause, or hormonal imbalances.
Apply this topical cream as directed by your healthcare provider. Generally, it should be applied to clean, dry skin on areas recommended by your doctor, such as the arms, thighs, or abdomen. Use the pump mechanism to dispense the prescribed amount of cream and spread it evenly on the skin.
No, you should follow your healthcare provider’s instructions for the application. Typically, it should not be applied to sensitive areas, such as the breasts, face, or mucous membranes, unless directed to do so by your healthcare professional.
The pump mechanism is designed to dispense a controlled amount of cream with each pump. Before the first use, you may need to prime the pump by pressing it several times until the cream is dispensed. Thereafter, the pump should dispense the same amount of cream with each press. If your dosage requires multiple pumps, apply each pump separately and rub in thoroughly.
Gloves are not usually required when applying the cream, but you should wash your hands thoroughly after application to avoid accidentally transferring the medication to others or to other parts of your body.
It typically takes a few minutes for the cream to be absorbed into the skin. After application, allow the cream to dry completely before dressing or coming into contact with others to prevent them from being exposed to the hormones.
If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
After applying the cream, wait at least 1 hour before showering, bathing, or swimming to ensure that the medication has been sufficiently absorbed into the skin.
As with any medication, side effects are possible. Some common side effects of hormone replacement therapy can include skin irritation at the application site, nausea, headache, or changes in mood. If you experience any severe side effects or symptoms that concern you, contact your healthcare provider promptly.
Store the cream at room temperature away from light and moisture. Do not store it in the bathroom. Keep the medication out of reach of children and pets. Always check the label for specific storage instructions or ask your pharmacist.
This compounded cream contains hormones that are not recommended for use during pregnancy or while breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before use.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
