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This Metronidazole 20 mg/mL, Misoprostol 24 µg/mL, and Phenytoin 50 mg/mL Topical Gel is a semisolid formulation designed for easy and precise application on the skin through a pump mechanism. Its gel-like consistency ensures targeted treatment and effective absorption of active ingredients.
This formulation is used to treat a variety of skin conditions, including inflammatory skin disorders, wound healing, and localized infections. Metronidazole provides antimicrobial action, Misoprostol aids in reducing inflammation, and Phenytoin promotes tissue repair and regeneration.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This compounded topical gel combines Metronidazole 20 mg/mL, Misoprostol 24 µg/mL, and Phenytoin 50 mg/mL in a semisolid formulation dispensed through a pump mechanism. This design facilitates easy and precise application, allowing for targeted treatment and optimal absorption of the active ingredients into the skin.
When applied topically, it exhibits anti-inflammatory properties and helps reduce redness, swelling, and infection in skin conditions. It is commonly used in the treatment of rosacea, inflammatory lesions, and infected dermal ulcers.
Misoprostol is a synthetic prostaglandin E1 analog that promotes mucosal protection and enhances blood flow. In topical formulations, misoprostol may aid in wound healing by stimulating epithelial cell growth and improving local circulation. This can be beneficial in treating ulcers and lesions with poor healing tendencies.
Phenytoin, traditionally used as an anticonvulsant, has demonstrated efficacy in promoting wound healing when used topically. It is believed to stimulate fibroblast proliferation and enhance granulation tissue formation, accelerating the healing process of chronic wounds, pressure sores, and diabetic ulcers.
The combination of these three active ingredients in a topical gel provides a multifaceted approach to skin healing. Metronidazole addresses bacterial infection and inflammation, misoprostol enhances tissue regeneration and blood flow, and phenytoin accelerates wound healing. This synergistic effect makes the formulation particularly useful for treating complex skin conditions such as chronic ulcers, non-healing wounds, and other dermatological disorders that require comprehensive management.
Patients utilizing this topical gel should follow the application
When using the Metronidazole 20 mg/mL/Misoprostol 24 µg/mL/Phenytoin 50 mg/mL Topical Gel, it is crucial to consider potential drug interactions that may affect the efficacy and safety of the treatment. This formulation combines three active ingredients, each with its own interaction profile, which can be complex when used concurrently with other medications.
Metronidazole, an antibiotic and antiprotozoal agent, can interact with several systemic medications. Notably, it may potentiate the effects of oral anticoagulants like warfarin, increasing the risk of bleeding. Patients using this topical gel should be monitored for signs of increased bleeding if they are also on anticoagulant therapy. Additionally, metronidazole can interact with alcohol, leading to a disulfiram-like reaction characterized by nausea, vomiting, flushing, and tachycardia. Although this reaction is more common with oral administration, patients should be advised to avoid alcohol consumption during treatment.
Misoprostol, a prostaglandin analog, is primarily used for its gastroprotective and uterotonic properties. While systemic absorption from topical application is generally minimal, caution is advised when used in conjunction with other medications that may affect uterine contractility, such as oxytocic agents. Patients who are pregnant or planning to become pregnant should be informed of the potential risks, as misoprostol can induce uterine contractions and may lead to miscarriage or premature labor.
Phenytoin, an anticonvulsant, is known for its extensive interaction profile. It is a potent inducer of hepatic enzymes, which can lead to decreased plasma concentrations of drugs metabolized by the liver, such as oral contraceptives, corticosteroids, and certain antiretrovirals. Although systemic absorption from topical application is limited, prescribers should be aware of the potential for altered drug metabolism in patients using this gel. Additionally, phenytoin can interact with other central nervous system depressants, potentially enhancing sedative effects.
For both patients and prescribers, it is essential to review the patient's current medication regimen to identify any potential interactions before initiating treatment with this topical gel. Patients should be encouraged to report any unusual symptoms or side effects promptly. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy. We are here to assist you in ensuring safe and appropriate use of this medication.
The Metronidazole 20 mg/mL/Misoprostol 24 µg/mL/Phenytoin 50 mg/mL Topical Gel is a compounded formulation designed to deliver a combination of active pharmaceutical ingredients directly to the skin, providing targeted treatment for specific dermatological conditions. This semisolid gel is dispensed through a pump mechanism, ensuring easy and precise application, which enhances patient compliance and optimizes therapeutic outcomes.
Metronidazole is an antibiotic and antiprotozoal agent that works by inhibiting nucleic acid synthesis in microorganisms, leading to their death. Its anti-inflammatory properties help to calm irritated skin, making it a valuable component in this formulation for managing inflammatory dermatoses.
Misoprostol, a synthetic prostaglandin E1 analog, is included in this formulation for its ability to promote healing and protect the skin. It works by increasing the production of protective mucus and bicarbonate, enhancing blood flow to the affected area, and promoting cell regeneration. These actions make misoprostol beneficial in treating skin ulcers, wounds, and other conditions where enhanced healing is desired. Its inclusion in the gel formulation aids in the repair of damaged skin tissues and supports the overall healing process.
Phenytoin, traditionally used as an anticonvulsant, has been found to possess wound-healing properties when applied topically. It promotes fibroblast proliferation, collagen deposition, and angiogenesis, which are critical processes in wound healing. In this gel formulation, phenytoin works synergistically with metronidazole and misoprostol to accelerate healing and improve skin integrity.
The gel-like consistency of this formulation allows for easy application and absorption of the active ingredients into the skin. The pump mechanism ensures that patients and caregivers can dispense the correct amount of gel, minimizing waste and ensuring consistent dosing. This targeted delivery system maximizes the therapeutic effects of the active ingredients while minimizing systemic exposure and potential side effects.
For prescribers, this compounded formulation offers a versatile treatment option for patients with complex dermatological needs. The combination of metronidazole, misoprostol, and phenytoin addresses multiple aspects of skin pathology, providing anti-inflammatory, healing, and antimicrobial benefits. This makes it suitable for a range of conditions, including inflammatory skin disorders, chronic wounds, and ulcers.
Patients using this topical gel can expect a reduction in inflammation, enhanced healing of skin lesions, and overall improvement in skin health. It is important to follow the application instructions provided by your healthcare provider to achieve the best results. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy.
This compounded topical gel is designed for targeted treatment on the skin, utilizing the active ingredients Metronidazole, Misoprostol, and Phenytoin to address specific dermatological conditions.
The gel should be dispensed through the pump mechanism and applied directly to the affected area of the skin. Ensure the area is clean and dry before application for optimal absorption.
The frequency of application should be as directed by your healthcare provider, typically based on the specific condition being treated and individual patient needs.
It is generally advised to avoid applying the gel on broken or severely irritated skin unless directed by a healthcare professional, as it may cause further irritation or adverse effects.
Possible side effects may include skin irritation, redness, or itching at the application site. If you experience severe reactions, discontinue use and consult your healthcare provider.
Before using this gel with other topical treatments, consult your healthcare provider to avoid potential interactions or reduced effectiveness of the medications.
Store the gel at room temperature, away from direct sunlight and moisture. Keep the container tightly closed when not in use to maintain the integrity of the formulation.
While the gel is formulated for targeted treatment, it may not be suitable for all skin types. It is important to consult with a healthcare provider to determine if this formulation is appropriate for your skin condition.
If you miss a dose, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular application schedule. Do not double the dose to catch up.
Consult your healthcare provider before using this topical gel during pregnancy or while breastfeeding to ensure it is safe for you and your baby.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
