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The Metronidazole Benzoate 5%/Mupirocin 5% Topical Cream is a semisolid preparation that combines the antibacterial and anti-inflammatory properties of Metronidazole Benzoate with the antibiotic action of Mupirocin. This dual-action cream is specifically formulated to treat skin conditions such as rosacea, characterized by inflammation and redness, and secondary bacterial skin infections, including impetigo. The cream is dispensed in a pump mechanism, which allows for convenient, hygienic, and controlled application directly to the affected areas of the skin, ensuring localized treatment and optimal absorption of the active ingredients.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Metronidazole Benzoate 5%/Mupirocin 5% topical cream is a compounded medication designed for the treatment of specific skin conditions. The combination of these two antibiotics in a topical cream allows for a broad spectrum of antibacterial activity, which can be beneficial in treating skin infections such as impetigo, infected hair follicles, and certain types of dermatitis that have a bacterial component.
The cream is intended for external use only and should be applied to the affected area as directed by a healthcare provider. It is important to use this medication for the full prescribed length of time, even if symptoms improve before the medication is finished. Stopping the medication too early may result in a return of the infection. Patients should wash their hands before and after applying the cream unless the hands are the area being treated. The area of application should be clean and dry before the cream is applied. Patients should avoid contact with the eyes, nose, mouth, and other mucous membranes.
As with any medication, there may be potential side effects. Common side effects of Metronidazole Benzoate/Mupirocin topical cream may include local irritation, itching, or stinging. If these persist or worsen, or if patients experience severe reactions such as rash, swelling, or trouble breathing, they should seek medical attention immediately. It is also important to inform the healthcare provider of all medications currently being taken, as there may be potential interactions.
Patients should not use this cream if they have a known allergy to metronidazole, mupirocin, or any other components of the cream. It is also not recommended for use in patients with certain medical conditions without first consulting a healthcare provider. Pregnant or breastfeeding women should discuss the potential risks and benefits with their healthcare provider before using this medication.
For any questions or concerns regarding the use of Metronidazole Benzoate 5%/Mupirocin 5% topical cream, or to report any adverse effects, patients should reach out to their healthcare provider or pharmacist. It is important to follow the guidance provided by healthcare professionals to ensure safe and appropriate use of this medication.
Metronidazole Benzoate and Mupirocin are both antibiotics, but they work in different ways to treat bacterial infections. When combined in a 5%/5% topical cream, this formulation can be used to treat a variety of localized skin infections caused by susceptible bacteria.
Regarding drug interactions, since this is a topical preparation, systemic absorption is generally minimal. However, it is still important to consider potential interactions. Metronidazole, even when used topically, can interact with anticoagulants like warfarin, potentially enhancing their effect and increasing the risk of bleeding. Patients on anticoagulant therapy should be monitored closely for signs of bleeding. Additionally, alcohol should be avoided during treatment and for at least 24 hours after the last application of Metronidazole Benzoate, as it may produce a disulfiram-like reaction (flushing, nausea, vomiting).
Mupirocin has fewer reported systemic interactions due to its limited absorption through the skin. However, it is important to avoid concurrent application of other topical preparations on the same area to prevent possible interference with the action of Mupirocin or alteration of its absorption. This includes over-the-counter products and cosmetic preparations.
Patients with a history of hypersensitivity to Metronidazole, Mupirocin, or any other component of the formulation should not use this product. Caution is advised when using this cream in patients with significant hepatic impairment, as Metronidazole is metabolized by the liver, and systemic accumulation may occur, leading to adverse effects.
It is also important to note that prolonged use of any antibiotic may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, appropriate measures should be taken. The use of this cream should be limited to the prescribed duration to reduce the risk of developing antibiotic resistance.
As with all medications, it is essential to inform healthcare providers of all the medications you are currently taking, including prescription, over-the-counter, vitamins, and herbal supplements, to avoid potential interactions. If you have any questions or concerns about using this topical cream, please reach out to us at Bayview Pharmacy for further assistance.
The Metronidazole Benzoate 5%/Mupirocin 5% Topical Cream is a specialized formulation that combines the therapeutic effects of two antibiotics, metronidazole benzoate and mupirocin, each at a concentration of 5%. This cream is designed to be applied topically to the skin, where it exerts its action locally. The semisolid preparation is dispensed from a pump mechanism, which allows for a clean, convenient, and controlled application, ensuring that the correct dose is administered each time.
Metronidazole benzoate is a prodrug of metronidazole and works by being converted to the active form within the skin. Metronidazole disrupts DNA synthesis in these microorganisms, leading to their death. This makes it particularly useful in treating skin conditions like rosacea, which can have a bacterial component, and other skin infections caused by susceptible anaerobic bacteria.
Mupirocin, on the other hand, is an antibiotic that inhibits bacterial protein synthesis by binding to bacterial isoleucyl-tRNA synthetase. This action is highly specific to bacteria, making mupirocin a good choice for treating skin infections like impetigo, folliculitis, and furunculosis caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
The cream is intended for localized treatment, which means it targets the area where it is applied, minimizing systemic absorption and potential side effects. This localized effect, coupled with the broad-spectrum antibacterial properties of the active ingredients, makes the cream a versatile option for treating various bacterial skin infections.
Overuse or misuse of antibiotic creams can lead to resistance and decreased effectiveness over time. As with any medication, adherence to the prescribed treatment regimen is crucial for the best therapeutic outcomes.
If you have any questions about this formulation or its appropriate use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary information and support to ensure appropriate treatment for your patients.
This combination cream is typically used for treating certain skin infections and conditions that benefit from the anti-inflammatory effects of metronidazole and the antibiotic action of mupirocin. It may be prescribed for issues like rosacea or infected wounds, although your healthcare provider should determine its suitability for your specific condition.
The cream should be applied to the affected area as directed by your healthcare provider. Generally, a thin layer should be applied to the clean, affected area twice daily, or as recommended. Use the pump to dispense the correct amount as prescribed.
You should follow your healthcare provider's instructions regarding dressing the treated area. Some conditions may require open air to heal, while others might benefit from the use of a breathable bandage. Don't use occlusive dressings unless advised by your physician.
As with all medications, there can be side effects. Commonly reported side effects include local irritation, itching, redness, or dryness of the treated skin. If you experience severe or persistent side effects, you should contact your healthcare provider.
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra cream to make up for the missed dose.
The use of this cream in children should be under the guidance and supervision of a healthcare provider. It’s important to follow the prescribed dose and instructions specifically provided for the child.
Store the cream at room temperature, away from excess heat and moisture. Do not freeze it. Keep it out of reach of children and pets, and make sure the cap is securely fastened after each use to maintain the integrity of the product.
Consult your healthcare provider before using this medication if you are pregnant or breastfeeding. Your provider will discuss the potential risks and benefits to determine if this cream is safe for you to use during this time.
Before using other medications or skin care products in conjunction with this cream, check with your healthcare provider or pharmacist. There may be potential interactions or increased risk of side effects with certain combinations.
Yes, Metronidazole Benzoate 5%/Mupirocin 5% Topical Cream is a compounded medication that requires a prescription from a healthcare provider who has assessed your condition and determined that this medication is appropriate for your use.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
