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The Salicylic Acid 40%/Cimetidine 10%/Fluorouracil 2%/Deoxy-D-Glucose 0.2% Topical Warts Cream is a specially compounded semisolid preparation intended for the treatment of common and plantar warts. This formulation combines the keratolytic effects of salicylic acid with the antiviral and immunomodulating properties of cimetidine and fluorouracil, respectively. Deoxy-D-Glucose is included to potentially inhibit the metabolic pathways of the virus-infected cells. The cream is dispensed in a pump mechanism, which allows for convenient and controlled application, ensuring precise dosing and targeted treatment of the affected skin areas.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Salicylic Acid 40%/Cimetidine 10%/Fluorouracil 2%/Deoxy-D-Glucose 0.2% Topical Warts Cream is a specially compounded formulation designed to treat warts through a multi-faceted approach. Salicylic acid, a keratolytic agent, works by softening the keratin in the skin, making it easier to shed skin cells and thus reducing the thickness of the wart. This action allows for the other active ingredients to penetrate more effectively. Cimetidine, traditionally used as an H2 antagonist for gastric issues, has been shown to have an immunomodulatory effect that may help in the resolution of warts by enhancing the body's immune response to the human papillomavirus (HPV), which causes warts.
Fluorouracil, a topical chemotherapeutic agent, inhibits the proliferation of the viral-infected cells, leading to their eventual destruction. Deoxy-D-Glucose, included at a low concentration, is thought to work by inhibiting glycolysis in the rapidly growing wart cells, thereby reducing their energy supply and potentially enhancing the efficacy of the other ingredients. The cream is formulated as a semisolid preparation dispensed in a pump mechanism, which allows for a controlled and hygienic application, ensuring that the correct dose is applied to the wart each time.
This combination therapy targets warts from multiple angles: physically removing the wart tissue, enhancing the immune response, inhibiting cell growth, and cutting off the energy supply to the wart cells. It is important for patients to understand that treatment may require several weeks to months, and they should adhere to the prescribed regimen for optimal results. Prescribers should monitor patient progress and adjust treatment as necessary, considering the potential for skin irritation or other side effects. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. We are here to support both patients and healthcare providers with expert advice and customized care.
The formulation you have described is a compounded topical cream intended for the treatment of warts, combining several active ingredients with different mechanisms of action. Salicylic acid is a keratolytic agent that helps to exfoliate the skin and remove warts by breaking down keratin, a protein that forms part of the skin structure. Cimetidine, traditionally used as an H2 receptor antagonist for reducing stomach acid, has been observed to have an immunomodulatory effect that may help in the treatment of warts by enhancing the body's immune response to the human papillomavirus (HPV). Fluorouracil is an antimetabolite that inhibits the synthesis of DNA and RNA, disrupting the growth of rapidly dividing cells, such as those found in warts. Deoxy-D-glucose is included for its potential to interfere with the metabolism and growth of the HPV virus.
When using this compounded formulation, it is important to consider potential drug interactions, especially if the patient is using other topical or systemic medications. Salicylic acid can increase the absorption of other topically applied medications, potentially enhancing their effects or side effects. It is advisable to use caution when applying other topical agents on the same area where this wart cream is used. Cimetidine, although used topically in this formulation, could theoretically have systemic absorption in small amounts. When taken orally, cimetidine is known to interact with a variety of medications by inhibiting certain liver enzymes (CYP450) involved in drug metabolism. This could potentially alter the metabolism of systemic medications, leading to increased levels and potential toxicity, or decreased effectiveness. However, the risk of such interactions is likely lower with topical application.
Fluorouracil, even when used topically, can be absorbed systemically and may interact with other drugs that affect cell division and DNA/RNA synthesis. It is important to monitor for increased side effects if the patient is taking other medications with similar mechanisms of action or those that are known to be toxic to the bone marrow. Deoxy-D-glucose is less well-studied in terms of drug interactions, but caution should be exercised when using this medication in combination with other treatments that affect cellular metabolism or glucose utilization.
Patients should be advised to inform their healthcare providers of all medications they are currently taking, including over-the-counter drugs and supplements, to assess for potential drug interactions. Prescribers should review the patient's medication profile for interactions and adjust therapy as needed. If you have any questions or require further information regarding this formulation and its potential interactions, please reach out to us at Bayview Pharmacy for assistance.
The Salicylic Acid 40%/Cimetidine 10%/Fluorouracil 2%/Deoxy-D-Glucose 0.2% Topical Warts Cream is a specially compounded formulation designed to treat warts through a multi-faceted approach. Each component of the cream plays a unique role in the treatment process, and when combined, they offer a comprehensive treatment strategy for patients suffering from warts.
Salicylic acid is a keratolytic agent, which means it helps to dissolve the protein (keratin) that makes up most of the wart and the thickened layer of skin that covers it. By softening and dissolving these proteins, salicylic acid enables the wart to be more easily shed from the surface of the skin.
Cimetidine, traditionally used as an H2 antagonist for reducing stomach acid, has been found to have immunomodulatory effects that may help in the treatment of warts. At a 10% concentration, cimetidine is believed to enhance the body's immune response to the human papillomavirus (HPV), which is responsible for the development of warts. By potentially boosting the immune system's ability to fight the virus, cimetidine may aid in the reduction and clearance of warts.
Fluorouracil is a topical chemotherapy agent that works by inhibiting the synthesis of DNA in rapidly dividing cells, such as those found in warts. At a 2% concentration, fluorouracil selectively targets the abnormal growth of wart tissue, causing the cells to die and the wart to diminish. This ingredient is particularly useful for persistent warts that have not responded to other treatments.
Deoxy-D-Glucose, at a 0.2% concentration, is included for its potential to interfere with the metabolism and growth of the wart cells. It is structurally similar to glucose but cannot be fully utilized by cells for energy. This "metabolic blocking" can inhibit the growth and proliferation of the wart cells, thereby assisting in the treatment process.
The cream is formulated as a semisolid preparation and is dispensed in a pump mechanism. This delivery system allows for convenient and controlled application, ensuring that the correct dose is applied to the wart each time. The pump also helps to prevent contamination of the product, maintaining its integrity throughout the course of treatment.
This combination of ingredients in the Salicylic Acid 40%/Cimetidine 10%/Fluorouracil 2%/Deoxy-D-Glucose 0.2% Topical Warts Cream targets warts from multiple angles: keratolysis, immune modulation, cytotoxicity, and metabolic interference. This multifaceted approach increases the likelihood of successful wart treatment. It is important for patients and prescribers to understand that treatment may take several weeks to months, depending on the size and stubbornness of the warts, and that consistent application as directed is crucial for effectiveness.
If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide guidance and support to ensure the best possible outcomes for our patients.
This compounded cream is specifically formulated to treat warts by combining the effects of salicylic acid, cimetidine, fluorouracil, and deoxy-D-glucose. Salicylic acid helps to exfoliate the skin, cimetidine acts to reduce inflammation, fluorouracil interferes with wart growth, and deoxy-D-glucose is included to potentially disrupt the metabolism of the wart cells.
The cream should be applied directly onto the wart and surrounding area using the pump mechanism, which allows for a controlled and consistent dosage. It's important to follow your healthcare provider’s instructions regarding the amount and frequency of application.
While this cream is designed to treat common warts, it's important to consult with a healthcare provider to determine if this specific formulation is appropriate for the type of wart you have. This is especially true for sensitive areas or genital warts, which may require a different treatment approach.
As with any medication, side effects are possible. Common side effects might include skin irritation, redness, and peeling at the application site. If you experience severe discomfort or signs of an allergic reaction, contact your healthcare provider immediately.
The frequency of application will depend on your healthcare provider’s instructions. It is important not to use it more often than prescribed, as overuse may lead to increased skin irritation or other side effects.
If you miss a dose, apply the cream as soon as you remember, unless it's almost time for your next application. In that case, skip the missed dose and resume your regular dosing schedule. Do not double up on applications to make up for a missed dose.
The safety of this formulation during pregnancy or breastfeeding has not been fully established. It is essential to consult with your healthcare provider before using this cream if you are pregnant, planning to become pregnant, or are breastfeeding to understand any potential risks.
It is usually recommended to allow the cream to dry and absorb into the skin without covering it with a bandage, unless your healthcare provider has instructed otherwise. Covering the area can sometimes increase absorption of the medication, which may lead to increased side effects.
Avoid using other topical products on the treated area unless directed by your healthcare provider, as they may affect the absorption or efficacy of the wart cream. Additionally, it's advisable to protect the area from direct sunlight and avoid using the cream just before engaging in activities that may cause heavy sweating.
This cream should be stored at room temperature, away from direct heat and sunlight. Keep the container tightly closed and out of reach of children and pets. Do not freeze the cream, as this may affect its effectiveness.
If someone ingests this cream, or if you suspect an overdose, seek medical attention immediately or contact a poison control center. Provide them with the details of the formulation so they can give you specific advice.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
