Verapamil HCL 15% Topical Cream is a specially compounded medication formulated to deliver verapamil hydrochloride, a calcium channel blocker, through the skin for localized treatment. This semisolid preparation is dispensed in a pump mechanism, which allows for convenient, controlled, and consistent application. The cream is designed to be applied directly to the affected area, providing targeted relief and minimizing systemic absorption, which can reduce potential side effects commonly associated with oral administration of verapamil.

The primary use of Verapamil HCL 15% Topical Cream is for the treatment of Peyronie's disease, a condition characterized by the development of fibrous scar tissue inside the penis, leading to curved, painful erections. Verapamil, when applied topically, is thought to disrupt the production and secretion of collagen and fibronectin by fibroblasts, which can help in reducing the size of plaques and alleviate the curvature and discomfort associated with this condition. Additionally, this formulation has been used off-label for the treatment of plantar fibromatosis (Ledderhose disease) and Dupuytren's contracture, conditions that are also characterized by the abnormal thickening of the connective tissue in the feet and hands, respectively.

For patients and prescribers considering Verapamil HCL 15% Topical Cream, it is important to note that the effectiveness of the treatment can vary from patient to patient, and consistent application as directed by a healthcare professional is crucial for optimal results. The cream should be applied to clean, dry skin, and patients should be advised to wash their hands before and after application to avoid transferring the medication to other areas of the body or to other individuals. As with any medication, there may be potential side effects, which can include local skin reactions such as itching, redness, or irritation at the site of application. It is essential to monitor for these reactions and report any severe or persistent symptoms to a healthcare provider.

Compounded Verapamil HCL 15% Topical Cream is not a commercially manufactured product and should only be prepared by a compounding pharmacy with expertise in creating such formulations. Bayview Pharmacy is equipped to compound this medication with precision and quality, ensuring that each batch meets the required standards for potency and consistency. If you have any questions or require further information about Verapamil HCL 15% Topical Cream, please do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists is here to support both patients and prescribers with their medication needs.

Verapamil HCL (hydrochloride) is a calcium channel blocker that is commonly used orally to treat high blood pressure, angina, and certain heart rhythm disorders. When formulated as a 15% topical cream, it is typically used for localized treatment of conditions such as Peyronie's disease or plantar fibromatosis. The topical application of verapamil aims to reduce collagen deposition and fibrous tissue formation. However, even when applied topically, verapamil can be absorbed systemically and may interact with other medications.

Patients should be aware that verapamil can interact with a wide range of drugs, potentially altering their effects or increasing the risk of adverse reactions. For example, concurrent use with beta-blockers or digoxin can lead to an increased risk of heart problems, including bradycardia (slow heart rate) and heart block. Verapamil may also increase the serum concentration of drugs that are substrates of the CYP3A4 enzyme, such as statins, leading to an increased risk of side effects like myopathy or rhabdomyolysis. Additionally, when used with drugs that lower blood pressure, there may be an additive hypotensive effect, which could result in dizziness or fainting.

Patients taking medications such as anticonvulsants (e.g., carbamazepine), immunosuppressants (e.g., cyclosporine), or certain antiarrhythmic drugs should be closely monitored for increased serum levels and potential toxicity. Verapamil can also interact with grapefruit juice, leading to increased drug levels and a higher risk of adverse effects. It is important to avoid consuming grapefruit or grapefruit juice while using this medication unless your healthcare provider advises otherwise.

It is crucial for patients to inform their healthcare providers of all medications they are currently taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions. Healthcare providers should evaluate the patient's medication regimen to identify any possible interactions before prescribing verapamil HCL 15% topical cream.

For prescribers, it is recommended to review the patient's current medications for any drugs that may interact with verapamil. Adjustments to therapy or additional monitoring may be necessary to ensure patient safety. If systemic absorption of topical verapamil is a concern, particularly in patients with compromised skin barriers or those applying the cream to large areas of the body, consider evaluating plasma levels of verapamil and the interacting drugs when appropriate.

If you have any questions or require further information regarding potential drug interactions with verapamil HCL 15% topical cream, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

Verapamil HCl 15% Topical Cream is a specially formulated medication that is designed to deliver verapamil hydrochloride, a calcium channel blocker, directly to the affected area of the skin. The active ingredient, verapamil, works by inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This action leads to a decrease in vascular resistance and an increase in coronary blood flow, which can be beneficial in treating conditions such as Peyronie's disease and plantar fibromatosis.

In the case of Peyronie's disease, verapamil helps by disrupting the production of collagen, a key component in the formation of fibrous plaques that cause the characteristic penile curvature. By reducing the production and secretion of collagen and possibly by breaking down the existing plaque, verapamil can help to reduce the curvature and associated pain. For plantar fibromatosis, also known as Ledderhose's disease, verapamil's ability to inhibit the formation of fibrous tissue can help in reducing the size and tenderness of nodules on the soles of the feet.

The cream is compounded into a semisolid preparation that is dispensed in a pump mechanism. This delivery system is designed for ease of use, allowing for a controlled and consistent application of the medication. The pump helps to prevent contamination of the product and ensures that the correct dose is applied each time. When the cream is applied topically, verapamil is absorbed through the skin directly into the affected area, providing localized treatment without the systemic effects that oral administration of the drug might cause.

It is important for patients and prescribers to understand that the effectiveness of Verapamil HCl 15% Topical Cream can vary from person to person and that consistent application as directed is necessary to see potential benefits. The formulation is intended for external use only and should be applied to clean, intact skin. Patients should be advised to wash their hands before and after applying the cream unless the hands are the area being treated.

If you have any questions about Verapamil HCl 15% Topical Cream or its use in treating Peyronie's disease or plantar fibromatosis, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to effectively use this formulation.

Verapamil HCl 15% Topical Cream is primarily known for its use in the treatment of plantar fibromatosis (Ledderhose disease) and Peyronie’s disease, where its role as a calcium channel blocker may help in disrupting the fibrotic process. However, the topical application of Verapamil presents a potential for off-label uses, one of which includes the treatment of certain types of keloids and hypertrophic scars. By inhibiting the influx of calcium, Verapamil may reduce collagen synthesis and fibroblast proliferation, which are elemental in scar formation. Furthermore, research suggests that topical Verapamil may have some benefit in localized areas of muscle spasm or myofascial pain, although such uses would be considered experimental and should be approached with caution.

Other anecdotal reports point to the potential use of Verapamil cream in the management of chronic anal fissures. The rationale behind this off-label use is that Verapamil can exert a relaxing effect on the smooth muscles, potentially reducing spasm and allowing for better perfusion and healing of the fissure. However, there is a need for more evidence to support this application. In the field of dermatology, there is growing interest in the impact of calcium channel blockers like Verapamil on hair growth. While no formal recommendations can be made until further studies are conducted, it is an area of interest for patients with hair loss disorders such as alopecia areata.

As compounding pharmacists, we are aware that each patient's situation is unique, and we emphasize that all off-label uses should be pursued under the guidance of a healthcare professional well-versed in the condition being treated. We strongly encourage prescribers and patients to discuss the potential benefits and risks of using Verapamil HCl 15% Topical Cream for conditions other than those for which it is indicated. Should you have any questions about this formulation, or wish to discuss the potential for other uses, please reach out to us at Bayview Pharmacy for a professional consultation. We are well-equipped to provide support and facilitate a collaborative approach to patient care.