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Amitriptyline HCL 1%/Ketoprofen 5%/Tetracaine HCL 2% Transdermal Gel

Custom-compounded at Bayview Pharmacy, this transdermal gel combines Amitriptyline, Ketoprofen, and Tetracaine to help manage neuropathic pain, arthritis, and fibromyalgia.
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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Ketoprofen
Tetracaine Hydrochloride
Topical Gel
652f56c026c88aed57fca40b

Formula Information

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This formulation is a compounded transdermal gel containing Amitriptyline HCL 1%, Ketoprofen 5%, and Tetracaine HCL 2%. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed directly into the targeted area, providing localized treatment.

Amitriptyline HCL is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. Tetracaine HCL is a local anesthetic that works by blocking nerve signals in your body, thereby numbing the specific area of application.

This formulation is typically used to treat conditions that involve pain and inflammation. These may include neuropathic pain, arthritis, musculoskeletal pain, and certain types of dermatological conditions. The combination of these three active ingredients works synergistically to provide pain relief, reduce inflammation, and numb the affected area, providing comprehensive treatment.

It is important to note that this formulation should be used as directed by a healthcare provider. The gel should be applied to the affected area in the amount specified by the prescriber. Avoid contact with eyes, mouth, and other mucous membranes. If any adverse reactions occur, such as skin irritation or allergic reactions, discontinue use and contact your healthcare provider immediately.

As compounding pharmacists, we are able to customize this formulation to meet the specific needs of individual patients. This includes adjusting the concentration of the active ingredients, altering the base of the gel, or adding other active ingredients as needed.

If you have any questions about this formulation, or if you are a healthcare provider interested in prescribing this treatment, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to provide you with the information and support you need to make informed decisions about your healthcare.

Drug Interactions

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This formulation contains Amitriptyline HCL, Ketoprofen, and Tetracaine HCL, all of which can interact with other medications. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Amitriptyline HCL, a tricyclic antidepressant, can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. Combining these drugs can lead to serious side effects such as serotonin syndrome, increased heart rate, and elevated blood pressure. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with blood thinners, other NSAIDs, corticosteroids, and certain antihypertensive medications. These interactions can increase the risk of gastrointestinal bleeding and ulcers, and may also affect kidney function. If you're taking aspirin to prevent heart attack or stroke, using ketoprofen might decrease that protective effect.

Tetracaine HCL, a local anesthetic, can interact with other local anesthetics and certain antiarrhythmic drugs. These interactions can lead to serious side effects such as slow heart rate, low blood pressure, and breathing problems. It's also important to avoid applying this medication to broken or inflamed skin, as it can increase the absorption of the drug and lead to systemic side effects.

This formulation is designed to provide targeted treatment for conditions such as neuropathic pain, inflammation, and localized pain. Amitriptyline HCL can help manage neuropathic pain by altering the way your body senses pain. Ketoprofen reduces inflammation and pain in the body by inhibiting the production of certain substances that cause inflammation. Tetracaine HCL works by blocking nerve signals in your body, providing local anesthesia and relieving pain.

It's crucial to use this medication exactly as prescribed by your healthcare provider. Avoid applying more than the recommended dose, as it can increase the risk of side effects. If you experience any unusual symptoms while using this medication, contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information you need to use this medication safely and effectively.

How Does it Work

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This formulation combines three active ingredients: Amitriptyline HCL, Ketoprofen, and Tetracaine HCL, each with a unique mechanism of action to provide relief from various disease states. The formulation is designed to be applied topically, directly to the skin, where it is absorbed into the body to exert its therapeutic effects.

Amitriptyline HCL is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, relieve anxiety, and treat certain types of chronic pain. It is often used in pain management for conditions such as neuropathic pain. When applied topically, Amitriptyline HCL can provide targeted relief at the site of pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis. In this formulation, Ketoprofen provides localized anti-inflammatory and analgesic effects.

Tetracaine HCL is a local anesthetic that works by blocking nerve signals in your body. It is used to numb different parts of the body to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, teething pain, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body. In this formulation, Tetracaine HCL provides immediate, localized pain relief.

The transdermal gel formulation allows for the active ingredients to be absorbed through the skin directly into the bloodstream. This provides targeted relief and minimizes systemic side effects that can occur with oral administration. The pump mechanism allows for easy and precise application of the medication.

This formulation is typically used for conditions that involve inflammation and pain, such as arthritis, neuropathic pain, and other similar conditions. It provides a multi-pronged approach to pain management, addressing both the symptoms and the underlying causes of pain.

If you have any questions about this formulation, how it works, or how it can be used to treat specific conditions, please don't hesitate to reach out to us. We are here to provide the information and support you need to make informed decisions about your health.

Other Uses

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The Amitriptyline HCL 1%/Ketoprofen 5%/Tetracaine HCL 2% Transdermal Gel is primarily used to manage pain associated with diseases such as neuropathic pain disorders, inflammation and some surgical procedures, due to the analgesic properties of its active ingredients. However, there could be several other potential uses for this formulation.

Amitriptyline is a tricyclic antidepressant that has been employed off-label for treating chronic pruritis (itching). By blocking histamine receptors, it may help reduce itching in conditions like lichen planus, eczema, and certain dermatoses. Similarly, these properties may make the gel useful in alleviating symptoms of vulvodynia.

Given ketoprofen's anti-inflammatory properties, this gel might also be beneficial in managing localized inflammation occurring as a result of sports injuries, rheumatoid arthritis, or osteoarthritis. Tetracaine, being a local anesthetic, numbs the specific area and provides relief from distress and discomfort, so it might also be valuable in conditions requiring localized anesthesia.

Furthermore, the combination of these three compounds could potentially be used for pain management in skin conditions associated with nerve damage, such as postherpetic neuralgia or trigeminal neuralgia, although more research would be needed in these areas.

It is important that patients and prescribers consider potential side effects, which could include skin irritation or allergic reactions. Given the active ingredients, there could also be systemic side effects if absorbed in substantial quantities, such as drowsiness, weakness or confusion stemming from the amitriptyline. As always, the gel should only be used as directed by a healthcare provider and is not suitable for application on open wounds or mucous membranes.

For any further questions or more detailed information about the formulation, patients and prescribers can reach out to us at Bayview Pharmacy. We're always here to provide comprehensive and accurate information to ensure the safe and appropriate use of medications.

Frequently Asked Questions

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What is Amitriptyline HCL 1%/Ketoprofen 5%/Tetracaine HCL 2% Transdermal Gel?

This is a compounded transdermal medication that contains three active ingredients – Amitriptyline HCL, Ketoprofen, and Tetracaine HCL. This gel-based medicine is applied onto the skin for targeted delivery of the active ingredients.

How do I apply this transdermal gel?

The medication is dispensed through a pump mechanism for easy and precise application. It should be applied directly to the area of the skin where treatment is needed.

What is the consistency of this medication?

Amitriptyline HCL 1%/Ketoprofen 5%/Tetracaine HCL 2% Transdermal Gel is a semisolid formulation that has a gel-like consistency. This enhances the comfort as well as the ease of application on the skin.

Does the medication get absorbed into the skin?

Yes, the active ingredients in the gel formulation are designed to be absorbed through the skin in a targeted manner, providing relief at the source.

How does this medication provide pain relief?

Ketoprofen, a strong non-steroidal anti-inflammatory drug (NSAID), provides pain relief by reducing inflammation, while tetracaine HCL is a local anesthetic that numbs the applied area. Amitriptyline HCL is an antidepressant that can also help manage chronic pain.

Can I use this medication all over the body?

This medication should only be used on the area advised by your health care provider or pharmacist. Incorrect use could lead to unnecessary side effects.

Can all skin types use this medication safely?

Generally, this medication is considered safe for all skin types. However, some individuals may have unique skin sensitivities that may react differently. Speak to your doctor or pharmacist if you notice any reactions.

Is this transdermal gel suitable for chronic pain?

Yes, it is often used for chronic pain relief as it delivers medication at the source of the pain. However, the suitability will depend on the specific kind of pain and your overall health condition. Consultation with a healthcare provider is recommended.

Can I take other pain medications while using this gel?

While this gel contains pain relief medication, your healthcare provider may or may not advise additional medicines based on your condition. Always consult your healthcare provider before making any changes to your medication regimen.

What should I do if I develop a skin reaction to this gel?

If a skin reaction is noticed, such as redness, itchiness or rashes, discontinue use of the product immediately and contact your healthcare provider.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Related Formulas

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NY, NJ, NH, FL, and ME. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCL 1%/Ketoprofen 5%/Tetracaine HCL 2% Transdermal Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)