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Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel

This formulation is a combination of Amitriptyline HCl 2%, Ibuprofen 10%, Lidocaine HCl 5%, and Orphenadrine HCl 5% in a topical gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant that can help manage chronic pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Lidocaine HCl is a local anesthetic that provides temporary relief from pain and discomfort. Orphenadrine HCl is a muscle relaxant that helps to relieve pain and stiffness in muscles and can be used in the treatment of muscle spasms.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NY, NJ, NH, FL and ME.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NY, NJ, NH, FL and ME.

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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Ibuprofen
Lidocaine Hydrochloride
Orphenadrine Hydrochloride
Topical Gel
653018f77a5cc2736c33f1e9

Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 2%, Ibuprofen 10%, Lidocaine HCl 5%, and Orphenadrine HCl 5%. It is designed to be dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the targeted area for optimal therapeutic effect.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body by inhibiting the production of prostaglandins, substances in the body that cause inflammation.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body, thereby reducing pain and discomfort in the applied area. Orphenadrine HCl is a muscle relaxant that works by blocking pain sensations between the nerves and the brain. It is used to treat muscle spasms and to relieve pain and stiffness in muscles.

This formulation is particularly useful in managing conditions that involve pain and inflammation, such as arthritis, muscle spasms, neuropathic pain, and fibromyalgia. By applying the gel directly to the affected area, patients can experience targeted relief from pain and inflammation. The combination of these four active ingredients provides a multi-modal approach to pain management, addressing pain at different levels and through different mechanisms.

It is important to use this medication as directed by your healthcare provider. Apply a thin layer of the gel to the affected area and rub in gently until it is absorbed. Do not apply this medication to broken or irritated skin. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any adverse reactions such as rash, itching, severe dizziness, or trouble breathing, contact your healthcare provider immediately.

As compounding pharmacists, we are here to answer any questions you may have about this formulation. Please do not hesitate to reach out to us if you need further information or clarification.

Drug Interactions

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This formulation contains Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl. Each of these active ingredients can interact with other medications, potentially altering their effects. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Amitriptyline HCl is a tricyclic antidepressant that can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. Combining these medications can lead to serious side effects such as serotonin syndrome, increased heart rate, and elevated blood pressure. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with blood thinners, other NSAIDs, corticosteroids, and certain antihypertensive medications. These interactions can increase the risk of gastrointestinal bleeding and impair kidney function. Ibuprofen can also reduce the effectiveness of certain blood pressure medications.

Lidocaine HCl is a local anesthetic that can interact with other local anesthetics and certain heart medications. These interactions can lead to serious side effects such as slow heart rate, low blood pressure, and seizures. It's also important to avoid applying this medication to broken or inflamed skin as it can increase absorption and lead to systemic side effects.

Orphenadrine HCl is a muscle relaxant that can interact with anticholinergic drugs, certain antihistamines, and MAO inhibitors. These interactions can increase the risk of side effects such as dry mouth, constipation, urinary retention, and confusion. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

This formulation is designed to provide targeted treatment for conditions such as muscle pain, inflammation, and nerve pain. Amitriptyline HCl can help manage nerve pain, Ibuprofen can reduce inflammation and pain, Lidocaine HCl can numb the affected area, and Orphenadrine HCl can relax the muscles. However, it's important to use this medication as directed by your healthcare provider and report any side effects immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us.

How Does it Work

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This unique formulation combines four active ingredients: Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl, each with its own mechanism of action to provide relief from pain and inflammation.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, and the body's response to pain. When applied topically, it can help reduce pain signals from the skin to the brain, providing localized relief.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing the production of prostaglandins, substances in the body that cause inflammation. This helps to decrease swelling, pain, or fever. When applied topically, it provides targeted relief from pain and inflammation at the site of application.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used topically to reduce pain or discomfort caused by skin irritations. It numbs the skin and surrounding area, providing immediate relief from pain.

Orphenadrine HCl is a muscle relaxant that works by blocking certain nerve impulses to provide relief from muscle spasms. It is used topically to provide localized relief from muscle pain and stiffness.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

This formulation can be used to treat various disease states that involve pain and inflammation, such as arthritis, muscle sprains and strains, nerve pain, and other conditions as directed by a healthcare provider.

It is important to use this medication as directed by your healthcare provider. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any side effects, such as skin irritation or allergic reactions, stop using the product and contact your healthcare provider immediately.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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While the primary use of the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel is to treat pain associated with conditions such as arthritis, nerve disorders, and muscle injuries, it also possesses several other utilities.

Firstly, this formulation can be used as an adjuvant in the management of neuropathic pain, such as post-herpetic neuralgia, post-stroke pain, diabetic neuropathy, and spinal cord injury. The combination of Amitriptyline, an antidepressant with analgesic properties, and Lidocaine, a local anesthetic, effectively numbs the area and lessens discomfort.

Secondly, the presence of Orphenadrine, a muscle relaxant, can provide significant benefit for patients suffering from muscle sprains and strains, muscular dystrophies or post-surgical muscle tension. The Ibuprofen in the formulation further amplifies the analgesic and anti-inflammatory effects for such conditions.

Additionally, the gel may be useful in managing conditions marked by muscle spasticity, like Multiple Sclerosis or certain types of cerebral palsy. It has also been used off-label for treating fibromyalgia and certain types of migraines, particularly those associated with muscle tension.

It is of utmost importance for users to consult with their respective healthcare professionals before considering this formulation for other uses. This ensures that potential benefits are evaluated against possible risks, including known side-effects such as skin irritation or allergic reactions.

If you have any further concerns or questions about the usage of the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel, please do not hesitate to reach out to us at Bayview Pharmacy. As expert compounding pharmacists, we are happy to assist and inform you about your medication to the best of our knowledge.

Frequently Asked Questions

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What is Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

This is a compounded formulation made from four active ingredients: Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl, used topically. The specific percentages denote the concentration of each ingredient within the gel.

How do I apply the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

This formulation comes with a pump mechanism. You should apply the recommended amount onto your skin by easily and precisely dispensing the gel using this pump.

What is the purpose of four active ingredients in the formulation?

The four active ingredients in this product are each used for a specific effect. Combined in this particular formulation, they work together to provide a targeted and more efficient treatment regime.

What is the consistency of this product?

The product is semisolid, with a gel-like consistency which allows for easy application and effective absorption.

Can this gel be used anywhere on the body?

Application should be targeted to the area where treatment is intended. Always consult your healthcare provider for precise instructions on where and how to use this gel.

Do I need a prescription for Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

Yes, this is a prescription medication and should be used under the supervision and direction of a healthcare provider.

What should I do if I experience any side effects?

If you experience any side effects or adverse reactions, stop the use immediately and contact your healthcare provider.

Is it safe to use this gel if I am pregnant or breastfeeding?

Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or are breastfeeding. They will determine if it is suitable for your condition.

Can I use this gel in conjunction with other medications?

You should discuss all ongoing medications with your healthcare provider before beginning treatment with this compounded formulation to prevent any potential interactions.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's close to your next application time, skip the missed dose and continue with your regular schedule. Do not double up doses.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NY, NJ, NH, FL, and ME. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)