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Amitriptyline HCl 5%/Carbamazepine 2%/Diclofenac Sodium 10%/Gabapentin 6% Topical Gel

This formulation is a compounded topical gel containing Amitriptyline HCl 5%, Carbamazepine 2%, Diclofenac Sodium 10%, and Gabapentin 6%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant used for its analgesic properties, Carbamazepine is an anticonvulsant and mood stabilizer, Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) for pain and inflammation, and Gabapentin is used for nerve pain relief. This formulation is often used in the management of conditions such as neuropathic pain, fibromyalgia, and certain types of chronic pain.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NY, NJ, NH, FL and ME.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NY, NJ, NH, FL and ME.

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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Carbamazepine
Diclofenac Sodium
Gabapentin
Topical Gel
65313da5a7e01d14ae208463

Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 5%, Carbamazepine 2%, Diclofenac Sodium 10%, and Gabapentin 6%. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to relieve chronic pain by increasing the levels of certain chemicals in the brain that help to transmit signals between nerve cells. Carbamazepine is an anticonvulsant that is used to treat nerve pain and seizures. It works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, swelling, and joint stiffness caused by arthritis. It works by blocking the production of certain substances in the body that cause inflammation. Gabapentin is an anticonvulsant and nerve pain medication that is used to treat seizures and pain caused by shingles. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

This formulation is used to treat a variety of disease states, including neuropathic pain, post-herpetic neuralgia, diabetic neuropathy, and other conditions that cause chronic pain.

It is important to use this medication exactly as prescribed by your healthcare provider. Apply the gel to the affected area as directed, usually 3-4 times daily. Do not apply more than the recommended dose, as this can increase the risk of side effects. Avoid contact with the eyes, nose, mouth, and other mucous membranes. Wash your hands thoroughly after applying the gel.

Side effects may include skin irritation at the application site, dizziness, drowsiness, dry mouth, and constipation. If any of these effects persist or worsen, notify your healthcare provider promptly. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your healthcare provider or pharmacist.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This topical gel formulation contains Amitriptyline HCl, Carbamazepine, Diclofenac Sodium, and Gabapentin. These active ingredients work synergistically to manage pain, particularly neuropathic pain, and inflammation. Amitriptyline HCl and Gabapentin are primarily used to treat nerve pain, Carbamazepine is an anticonvulsant and mood stabilizer that can also help with nerve pain, and Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation.

While this formulation is designed to minimize systemic absorption and thus reduce the risk of drug interactions, it is still important to be aware of potential interactions, especially if you are taking other medications. Here are some key interactions to be aware of:

Amitriptyline HCl: This medication can interact with MAO inhibitors, leading to serious effects such as high fever, muscle stiffness, and severe convulsions. It can also interact with anticholinergic drugs, thyroid medications, and certain antihypertensives. Additionally, it can increase the risk of serotonin syndrome when taken with other serotonergic drugs.

Carbamazepine: This drug can interact with many medications due to its enzyme-inducing properties. It can decrease the effectiveness of certain drugs including warfarin, doxycycline, and theophylline. It can also increase the risk of side effects when taken with drugs such as lithium, phenytoin, or isoniazid.

Diclofenac Sodium: This NSAID can interact with anticoagulants, increasing the risk of bleeding. It can also interact with other NSAIDs, corticosteroids, and alcohol, increasing the risk of gastrointestinal ulcers or bleeding. Additionally, it can reduce the effectiveness of certain antihypertensives and diuretics.

Gabapentin: This drug can increase the effects of alcohol and other CNS depressants. It can also interact with antacids, reducing the absorption of gabapentin.

It's important to inform your healthcare provider of all the medications you are currently taking, including over-the-counter drugs, dietary supplements, and herbal products. This will help your healthcare provider to manage potential drug interactions effectively.

Remember, this formulation is intended for topical use only and should not be ingested or applied to open wounds or damaged skin. If you experience any adverse reactions, discontinue use and contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to help you.

How Does it Work

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This formulation is a combination of four active ingredients: Amitriptyline HCl, Carbamazepine, Diclofenac Sodium, and Gabapentin. Each of these ingredients works in a unique way to provide relief from various disease states.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. When applied topically, it can provide targeted relief from pain without the systemic side effects associated with oral administration.

Carbamazepine is an anticonvulsant that is also used to relieve certain types of nerve pain. It works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity. In a topical formulation, it can provide direct relief at the site of pain.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. When applied topically, it can provide targeted relief from pain and inflammation without the gastrointestinal side effects associated with oral NSAIDs.

Gabapentin is an anticonvulsant and nerve pain medication. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. In a topical formulation, it can provide direct relief at the site of pain.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The active ingredients are delivered in a gel-like consistency, which facilitates absorption through the skin and targeted treatment of the affected area.

This formulation can be used to treat various disease states, including neuropathic pain, fibromyalgia, postherpetic neuralgia, and other conditions associated with nerve pain. It can also be used to treat localized pain and inflammation associated with conditions such as osteoarthritis.

As with any medication, it is important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, please reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists who are here to help.

Other Uses

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In addition to its primary use case, the Amitriptyline HCl 5%/Carbamazepine 2%/Diclofenac Sodium 10%/Gabapentin 6% Topical Gel has other potential uses for both patients and prescribers. As a compounding preparation, it is uniquely suited for providing personalized treatment options for various conditions and patient preferences.

Firstly, it might be worth considering this formulation for the relief of various types of chronic and acute pain conditions. Given the inclusion of Diclofenac Sodium, a potent Non-Steroidal Anti-Inflammatory Drug (NSAID), this topical agent could be effectively used for symptomatic relief of joint pain associated with osteoarthritis or sprains. Similarly, the presence of Gabapentin may provide a beneficial effect for neuropathic pain conditions, such as peripheral neuropathy or neuritis.

Furthermore, Amitriptyline HCl is a tricyclic antidepressant that has been recognized for its potential analgesic effects. While its exact pain-relieving mechanism is not entirely understood, it may help lessen certain types of chronic pain while concurrently providing benefits for combating depression in certain patients.

Carbamazepine, an anticonvulsant, is often employed for the treatment of seizures, but it can also have potential uses in certain types of pain such as trigeminal neuralgia, as well as in mood disorders like bipolar disorder. This corroborates the possible use of this formulation as an adjunctive treatment for patients with co-existing pain and mood conditions.

Aside from its potential pain management applications, this formulation could be explored for off-label uses in skin disorders, given its application method. It is worth noting, however, that these potential uses should be thoroughly evaluated by prescribers based on individual patient conditions and needs, taking into account potential side effects and patient tolerance.

It's important to keep in mind that the diverse constituents in this formulation can offer unique opportunities for personalized pain management, providing the advantage of incorporating several active ingredients into a single dosage form, which can be easily and accurately applied to the affected areas. It's also worth emphasizing that the dosage can be easily adjusted as per the patient's specific requirements due to its pump mechanism.

If you have any further questions or inquiries regarding this formulation or its potential uses, please don't hesitate to reach out to us at Bayview Pharmacy. As compounding pharmacists, we are dedicated to providing comprehensive information and personalized medications to meet our patients' unique needs. We welcome any and all questions about this formulation or any other compounding needs you may have.

Frequently Asked Questions

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What is the Amitriptyline HCl 5%/Carbamazepine 2%/Diclofenac Sodium 10%/Gabapentin 6% Topical Gel?

This is a compounded medication formulated as a semisolid gel. It contains four active ingredients – Amitriptyline HCl, Carbamazepine, Diclofenac Sodium, and Gabapentin – that work together to provide targeted treatment when applied topically on the skin.

How is this medication dispensed?

The medication is dispensed through a pump mechanism. This design facilitates easy and precise application of the gel on the skin.

What is the consistency of this topical gel?

The consistency of this medication is similar to a gel. It is neither too thick nor too thin for easy spreadability and absorption.

What is the purpose of the different active ingredients in the gel?

Each ingredient in the gel has a specific purpose. Amitriptyline HCl is an antidepressant that can also help relieve pain, Carbamazepine is used to control seizures, Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation, and Gabapentin is used to relieve nerve pain.

Where should I apply the topical gel?

You should apply the gel to the specific area of skin where you require treatment or relief, as indicated by your healthcare provider.

How should I store this medication?

Store the medication at room temperature, away from heat, moisture, and direct light. Always keep the container tightly closed when not in use.

What should I do in case of an overdose?

If you believe you have used too much of this medicine, seek emergency medical attention. Overdose symptoms may include nausea, vomiting, stomach pain, or unconsciousness.

Are there any side effects associated with this compounded formulation?

As with any medication, this compounded formulation can cause side effects. Some common side effects may include skin irritation or redness in the application area. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Can I use other medications while on this therapy?

Always inform your healthcare provider about other medications you may be taking, including prescription, over-the-counter, vitamins, and herbal supplements to avoid any potential drug interactions.

What happens if I miss a dose?

If you miss a dose, apply it as soon as possible. However, if it's near the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double doses.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NY, NJ, NH, FL, and ME. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCl 5%/Carbamazepine 2%/Diclofenac Sodium 10%/Gabapentin 6% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)