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Amphotericin B 125 mg Oral Capsules

Amphotericin B 125 mg Oral Capsules are a solid dosage form, consisting of two gelatin or vegetarian shells that enclose the medication. This formulation allows for convenient and easy swallowing, ensuring a precise dosage of the active ingredient, Amphotericin B. This potent antifungal medication is primarily used to treat a variety of serious fungal infections. The precise dosage of 125 mg in each capsule aids in effectively combating the disease states.

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Formula Information

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Amphotericin B 125 mg Oral Capsules are a solid dosage form that consists of two gelatin or vegetarian shells enclosing the medication. This design allows for easy swallowing and ensures a precise dosage of the active ingredients. Amphotericin B is a potent antifungal medication used to treat a variety of serious fungal infections.

Amphotericin B works by binding to ergosterol, a component of the fungal cell membrane, creating pores that lead to cell death. This mechanism of action allows it to effectively combat a wide range of fungal pathogens, including Candida, Aspergillus, and Cryptococcus species, among others. It is often used in cases where the infection is severe or resistant to other antifungal treatments.

While Amphotericin B is a powerful medication, it is important to note that it can cause side effects. These may include fever, chills, headache, nausea, and changes in kidney function. Regular monitoring of kidney function and electrolyte levels is recommended during treatment. It is also important to take the medication exactly as prescribed by your healthcare provider to ensure its effectiveness and minimize the risk of side effects.

Amphotericin B 125 mg Oral Capsules provide a convenient and precise dosage form for this medication. However, due to the potential for serious side effects and the need for regular monitoring, it is typically reserved for use in severe or refractory infections. If you have any questions about this medication or its use, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Drug Interactions

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Amphotericin B is an antifungal medication used to treat serious, potentially life-threatening fungal infections. These include infections caused by fungi such as Aspergillus and Candida, which can cause diseases like aspergillosis and candidiasis. It works by binding to the fungal cell membrane, causing changes in the membrane's permeability and leading to cell death.

While Amphotericin B is a potent antifungal, it's important to be aware of potential drug interactions. These interactions can alter the way Amphotericin B works or increase the risk of serious side effects.

Amphotericin B can interact with the following types of medications:

Antineoplastic Agents: Concurrent use of Amphotericin B with antineoplastic agents (cancer medications) can increase the risk of kidney damage and other side effects. This is due to the additive nephrotoxicity of these medications. If you are taking any cancer medications, inform your healthcare provider.

Corticosteroids and Corticotropin (ACTH): These medications can potentiate the development of hypokalemia (low potassium levels) when used with Amphotericin B. This can lead to heart problems. Regular monitoring of potassium levels is recommended.

Digitalis Glycosides: Hypokalemia induced by Amphotericin B can potentiate digitalis toxicity. If you are on a digitalis medication, your healthcare provider may need to monitor your potassium levels and adjust your digitalis dose as necessary.

Flucytosine: Using Amphotericin B with flucytosine can lead to an increased risk of flucytosine toxicity. Regular monitoring of flucytosine levels and kidney function is recommended.

Other Nephrotoxic Medications: Concurrent use of Amphotericin B with other nephrotoxic medications (medications harmful to the kidneys) can increase the risk of kidney damage. This includes medications like cisplatin, aminoglycoside antibiotics, and nonsteroidal anti-inflammatory drugs (NSAIDs).

It's important to inform your healthcare provider of all medications you are currently taking, including prescription medications, over-the-counter drugs, and dietary supplements. This will help your healthcare provider to prevent potential interactions and ensure the safe use of Amphotericin B.

Remember, this is not a complete list of possible drug interactions. Always consult with your healthcare provider or pharmacist for more information. If you have any questions, don't hesitate to reach out to us at Bayview Pharmacy.

How Does it Work

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Amphotericin B 125 mg Oral Capsules are a solid dosage form that consists of two gelatin or vegetarian shells enclosing the medication. This design allows for easy swallowing and provides a precise dosage of the active ingredients. The main active ingredient in this formulation is Amphotericin B, a potent antifungal medication.

Amphotericin B works by binding to ergosterol, a component of the fungal cell membrane. Once it binds to ergosterol, it forms pores in the cell membrane. These pores allow for the leakage of intracellular components, which leads to cell death. In this way, Amphotericin B disrupts the integrity of the fungal cell membrane and effectively kills the fungus, treating the infection.

This medication is used to treat a variety of serious fungal infections. It is often used when other less toxic drugs are ineffective or cannot be used, such as in individuals with severe fungal infections or those who are immunocompromised. It is effective against a wide range of fungi, including Candida, Aspergillus, Cryptococcus, and more.

It's important to note that while Amphotericin B is a powerful antifungal, it can also have significant side effects. These can include fever, chills, headache, nausea, and in some cases, kidney damage. Therefore, it's crucial that this medication is used under the supervision of a healthcare provider, and that patients are closely monitored for side effects.

As compounding pharmacists, we can customize the dosage and form of Amphotericin B to meet the specific needs of each patient. This can help to improve the effectiveness of the medication and reduce the risk of side effects. We can also provide advice and support to both patients and prescribers to ensure that this medication is used safely and effectively.

If you have any questions about Amphotericin B 125 mg Oral Capsules or any other aspect of compounding pharmacy, please don't hesitate to reach out to us. We're here to help.

Other Uses

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Amphotericin B 125 mg Oral Capsules are a potent formulation primarily used for the treatment of a wide range of fungal infections. These include pulmonary and systemic mycoses, cryptococcal meningitis, histoplasmosis, and candidiasis. However, there are several other uses for patients and prescribers to consider.

Amphotericin B Oral Capsules also find use as an important option for treatment or prophylaxis against fungal infections in patients undergoing chemotherapy or organ transplantation. These patients often have a weakened immune system, making them more susceptible to infections.

Furthermore, Oral Amphotericin B Capsules have shown effectiveness in the treatment of various parasitic infections like leishmaniasis. These capsules can therefore be utilized in cases where conventional antiparasitic treatments are contraindicated or ineffective.

For topical oral use, these capsules can be opened and the powder compounded with water to treat oral thrush. The antifungal properties of Amphotericin B can effectively eliminate the Candida infection commonly responsible for this condition.

Due to its broad antifungal spectrum, Amphotericin B is also sometimes used off-label in superficial fungal infections, where oral or topical antifungal agents have failed to produce satisfactory outcomes.

It's important to note, however, that prescribers should take into careful consideration the risk of potential side effects, such as nephrotoxicity and infusion-related reactions. Amphotericin B should only be used in cases where the benefits outweigh these potential risks. Patients taking Oral Amphotericin B Capsules should be closely monitored to ensure therapeutic efficacy and to minimize the possibility of adverse reactions.

To ensure safe use, patients should always follow the exact directions given by their healthcare provider, and inform them of all current medications and existing health conditions. As these 125 mg Oral Capsules provide a precise dosage, they should never be modified or used in any manner other than as directed by a professional.

If you have any questions regarding the use of Amphotericin B 125 mg Oral Capsules, please do not hesitate to reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is always ready to assist you with all your medication-related queries.

Frequently Asked Questions

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What is the purpose of Amphotericin B 125 mg Oral Capsules?

The purpose of Amphotericin B 125 mg oral capsules is to provide a precise dosage of the active ingredient Amphotericin B, which is used for the treatment of various types of serious fungal infections. Its solid dosage form allows for convenient and easy swallowing.

What does the "125 mg" in the name represent?

The "125 mg" refers to the quantity of the active pharmaceutical ingredient, Amphotericin B, contained in the medication. It represents the dosage strength, which means every capsule contains 125 milligrams of Amphotericin B.

What are these capsules made of?

The capsules are made of two gelatin or vegetarian shells which enclose the medication. These shells are easy to swallow and are designed to deliver a precise dosage of the active ingredients.

Are these capsules suitable for vegetarians?

Yes, the shells can be made of vegetarian ingredients instead of gelatin, making them suitable for those following a vegetarian diet. Please check with your pharmacist to ensure you have the vegetarian version.

How does the capsule form aid in convenience?

The capsule form makes it easier for patients to swallow. It also ensures a precise dosage of medication, as the active ingredients are pre-measured and encased in the shell.

What is the benefit of a "solid dosage form"?

A solid dosage form, like a capsule, allows for stable and precise dosage of the medication. It’s easier to transport, store, and it ensures that the patient receives the exact amount of active ingredient required for their treatment.

What is the active ingredient in this medication?

The active ingredient in this medication is Amphotericin B. This is an antifungal medication used to treat serious fungal infections in the body.

What happens if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it's near the time for your next dose, skip the missed dose and take the next one at the scheduled time. Do not double the dose.

Are there any side effects to this medication?

Like any medication, Amphotericin B may cause side effects. Common ones can include fever, chills, headache, or upset stomach. If you experience severe side effects or an allergic reaction, seek medical attention immediately.

How should I store my Amphotericin B capsules?

Amphotericin B capsules should be stored in a cool, dry place, away from direct sunlight. They should be kept out of reach of children. Do not store in the bathroom or near a sink due to moisture.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
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