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Capsaicin 7.5 mg/mL/Ketamine HCl 20 mg/mL/Ketoprofen 100 mg/mL Topical Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Capsaicin
Ketamine Hydrochloride
Ketoprofen

This topical gel formulation combines Capsaicin 7.5 mg/mL, Ketamine HCl 20 mg/mL, and Ketoprofen 100 mg/mL, designed for targeted treatment of pain and inflammation associated with conditions such as neuropathic pain, arthritis, and musculoskeletal disorders.

A semisolid formulation dispensed through a pump mechanism, facilitating easy and precise application on the skin for targeted treatment or absorption of active ingredients in a gel-like consistency.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
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Requires a prescription from your own provider. Bayview is a pharmacy and does not prescribe.
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Capsaicin
Ketamine Hydrochloride
Ketoprofen
Topical Gel
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This compounded topical gel combines Capsaicin 7.5 mg/mL, Ketamine HCl 20 mg/mL, and Ketoprofen 100 mg/mL in a semisolid formulation. Dispensed through a pump mechanism, it facilitates easy and precise application on the skin, ensuring targeted delivery of the active ingredients with a gel-like consistency.

Capsaicin, derived from chili peppers, is known for its analgesic properties. It works by desensitizing peripheral nociceptors and reducing the levels of substance P, a neuropeptide associated with pain transmission. This action can help alleviate discomfort in conditions involving neuropathic pain.

Ketamine HCl acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. When applied topically, it may interrupt pain signaling pathways by blocking NMDA receptors in the peripheral nerves, contributing to analgesia without significant systemic effects.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes COX-1 and COX-2, reducing the synthesis of prostaglandins responsible for inflammation and pain. Its topical application targets the affected area directly, minimizing systemic exposure and potential side effects associated with oral NSAIDs.

This combination gel is formulated to manage localized pain conditions such as neuropathic pain, musculoskeletal pain, arthritis, and other inflammatory disorders. By integrating agents that address different pain pathways, the gel offers a multimodal approach to pain relief.

The pump mechanism ensures accurate dosing and ease of use. Patients should apply the prescribed amount of gel to the affected area as directed by their healthcare provider. It is important to avoid contact with eyes, mucous membranes, and broken skin. Hands should be washed

Drug Interactions

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This topical gel formulation, containing Capsaicin 7.5 mg/mL, Ketamine HCl 20 mg/mL, and Ketoprofen 100 mg/mL, is designed for targeted treatment of pain and inflammation. It is important to consider potential drug interactions when using this formulation to ensure safety and efficacy. Capsaicin, a compound derived from chili peppers, is primarily used for its analgesic properties. It works by depleting substance P, a neuropeptide involved in transmitting pain signals. While topical capsaicin is generally considered safe, it may interact with other medications that affect nerve function or pain perception, such as certain antidepressants or anticonvulsants. Patients should inform their healthcare provider of all medications they are currently taking to avoid potential interactions.

Ketamine HCl, an NMDA receptor antagonist, is included in this formulation for its analgesic and anesthetic properties. However, ketamine may interact with other central nervous system (CNS) depressants, such as benzodiazepines, opioids, or alcohol, potentially leading to enhanced sedative effects. Patients should be advised to avoid or limit the use of other CNS depressants while using this gel to prevent excessive sedation or respiratory depression.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is included for its ability to reduce inflammation and pain. Topical application of ketoprofen minimizes systemic exposure, but there is still a potential for interaction with other NSAIDs or anticoagulants, which could increase the risk of gastrointestinal bleeding or other adverse effects. Patients should be cautioned against using other NSAID-containing products concurrently and should inform their healthcare provider if they are taking blood thinners or have a history of gastrointestinal issues.

Overall, while the topical application of this gel reduces the likelihood of systemic drug interactions, it is crucial for both patients and prescribers to be aware of the potential interactions with other medications, especially those affecting the CNS or having anticoagulant properties. Patients should be encouraged to discuss their full medication regimen with their healthcare provider to ensure safe use of this formulation. If you have any questions or concerns about potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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This topical gel formulation combines three active ingredients: Capsaicin, Ketamine HCl, and Ketoprofen, each contributing to its therapeutic effects. The semisolid gel is dispensed through a pump mechanism, ensuring easy and precise application on the skin, which is crucial for targeted treatment and optimal absorption of the active ingredients.

Capsaicin, derived from chili peppers, works by desensitizing sensory neurons and reducing the sensation of pain. It achieves this by depleting substance P, a neuropeptide involved in transmitting pain signals to the brain. When applied topically, capsaicin can provide relief from chronic pain conditions by diminishing the intensity of pain signals in the affected area.

Ketamine HCl is an NMDA receptor antagonist that has been shown to have analgesic properties. In this topical formulation, ketamine works by blocking the NMDA receptors in the peripheral nervous system, which are involved in the transmission of pain signals. This action helps in reducing pain perception and can be particularly beneficial for neuropathic pain conditions, where traditional pain medications may not be as effective.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for inflammation, pain, and fever. By reducing the levels of prostaglandins, ketoprofen helps to alleviate inflammation and pain in the affected area. Its inclusion in the gel formulation allows for localized anti-inflammatory effects, minimizing systemic exposure and potential side effects associated with oral NSAIDs.

The gel-like consistency of this formulation ensures that the active ingredients are delivered directly to the site of pain or inflammation, allowing for rapid absorption and onset of action. The pump mechanism facilitates precise dosing, ensuring that patients receive the correct amount of medication with each application. This targeted approach not only enhances the efficacy of the treatment but also reduces the risk of systemic side effects.

This combination of capsaicin, ketamine, and ketoprofen in a topical gel is designed to provide comprehensive pain relief by addressing multiple pathways involved in pain and inflammation. It is particularly useful for patients suffering from chronic pain conditions, such as neuropathic pain, arthritis, or localized musculoskeletal pain, where traditional oral medications may not provide adequate relief or may cause undesirable side effects.

If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

Frequently Asked Questions

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What is the purpose of the Capsaicin/Ketamine/Ketoprofen topical gel?

This topical gel is formulated to provide targeted relief from pain and inflammation. Capsaicin helps reduce pain signals, Ketamine acts as an analgesic, and Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation.

How should I apply the topical gel?

Dispense the gel using the pump mechanism and apply it directly to the affected area. Gently rub it into the skin until it is fully absorbed. Follow your healthcare provider's instructions regarding the amount and frequency of application.

Can I use this gel on broken or irritated skin?

No, you should not apply this gel to broken, irritated, or infected skin. Doing so may increase the risk of irritation or adverse effects. Consult your healthcare provider for guidance if you have concerns about skin conditions.

How often can I apply the gel?

The frequency of application should be determined by your healthcare provider. Typically, it is applied 2-4 times daily, but follow the specific instructions given to you by your healthcare professional.

Are there any side effects associated with this topical gel?

Some users may experience mild skin irritation, redness, or a burning sensation at the application site. If you experience severe irritation or an allergic reaction, discontinue use and consult your healthcare provider immediately.

Can I use this gel with other topical medications?

Before using this gel with other topical medications, consult your healthcare provider to avoid potential interactions or increased risk of side effects.

Is this gel safe for use during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, consult your healthcare provider before using this gel to ensure it is safe for you and your baby.

How should I store the topical gel?

Store the gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets to prevent accidental ingestion or misuse.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply extra gel to make up for a missed dose.

Can I use this gel for conditions other than pain and inflammation?

This gel is specifically formulated for pain and inflammation relief. Do not use it for other conditions unless directed by your healthcare provider.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Capsaicin 7.5 mg/mL/Ketamine HCl 20 mg/mL/Ketoprofen 100 mg/mL Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)

Three times daily