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Formulas

Clindamycin 2%/Tretinoin 0.05% Topical Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Tretinoin
Clindamycin Hydrochloride

This formulation is a Clindamycin 2%/Tretinoin 0.05% Topical Gel, a semisolid preparation designed for easy and accurate application on the skin. The gel is dispensed through a pump mechanism, ensuring targeted treatment and efficient absorption of the active ingredients. Clindamycin, an antibiotic, works by stopping the growth of bacteria, while Tretinoin, a form of vitamin A, helps the skin renew itself more quickly. This combination is commonly used to treat acne, reducing the number of acne pimples and promoting quick healing of pimples that do develop. It is also used to treat other skin conditions as determined by your healthcare provider.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Tretinoin
Clindamycin Hydrochloride
Topical Gel
653f7ac6aa67aec82e34d56e

Formula Information

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This formulation combines two active ingredients, Clindamycin and Tretinoin, in a topical gel form. Clindamycin is an antibiotic that works by stopping the growth of bacteria, while Tretinoin, a form of vitamin A, helps the skin renew itself more quickly. The gel is dispensed through a pump mechanism, which allows for easy and precise application on the skin.

Clindamycin 2%/Tretinoin 0.05% Topical Gel is primarily used to treat acne. It works by decreasing the number and severity of acne pimples and promotes quick healing of pimples that do develop. Clindamycin works by killing bacteria that cause acne, and Tretinoin works by increasing skin cell turnover and reducing the tendency of cells and keratin debris to clump together and clog pores. This dual-action approach helps to clear up acne and prevent new breakouts from forming.

It's important to note that this medication is for external use only. It should be applied to the affected areas of skin, usually once a day or as directed by your doctor. Avoid getting this medication in your eyes, nose, mouth, or in open wounds. If this medication gets into your eyes, rinse thoroughly with water. Also, this medication may make you more sensitive to the sun, so limit your time in the sun and avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

As with any medication, there may be side effects. These can include skin redness, dryness, itching, scaling, mild burning, or worsening of acne during the first 2 to 4 weeks of using the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. It's important to remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

For prescribers, it's important to note that this formulation should not be used by patients who are allergic to either Clindamycin or Tretinoin, or to any of the ingredients in the formulation. It should also not be used by patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Drug Interactions

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Clindamycin and tretinoin topical gel is a combination medication used to treat acne. Clindamycin is an antibiotic that stops the growth of acne-causing bacteria. Tretinoin is a form of vitamin A that helps the skin renew itself more quickly. Together, they effectively reduce the number of acne pimples and promote quick healing of pimples that do develop.

Using other topical acne medications at the same time as this gel may cause dryness or irritation of the skin. If you are using other topical acne medications, discuss with your doctor how to incorporate them into your treatment plan. This may involve applying the medications at different times of the day or on different days.

Oral or injectable medications that contain tretinoin, isotretinoin, or a similar active ingredient should be avoided while using this topical gel, as they may increase the risk of tretinoin's side effects. If you are taking any such medications, inform your doctor before starting treatment with this gel.

Clindamycin and tretinoin topical gel can also interact with certain other types of medications. These include erythromycin, which can compete with clindamycin for bacterial binding sites and potentially decrease its effectiveness, and neuromuscular blocking agents, which can interact with clindamycin to increase their effects. If you are taking any of these medications, your doctor may need to adjust your treatment plan accordingly.

It's also important to note that this medication can make your skin more sensitive to sunlight. Avoid prolonged sun exposure, tanning booths, and sunlamps, and use a sunscreen and wear protective clothing when outdoors. If you are using a product with a high amount of alcohol, such as an astringent or shaving cream, your skin may become dry or irritated. Discuss with your doctor whether you should continue using these products while on this medication.

Remember, your healthcare provider has prescribed this medication because they have judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. However, if you notice any signs of an allergic reaction, such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing, seek medical attention immediately.

If you have any questions about this medication or its potential interactions, don't hesitate to reach out to us at Bayview Pharmacy.

How Does it Work

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The Clindamycin 2%/Tretinoin 0.05% Topical Gel is a combination medication that works by targeting acne-causing bacteria and promoting skin cell turnover. Clindamycin, an antibiotic, works by inhibiting the synthesis of essential proteins required by bacteria to carry out vital functions. This action stops the growth of bacteria, reducing the number of acne-causing bacteria on the skin, and allowing the skin to heal.

Tretinoin, on the other hand, is a form of vitamin A that helps to increase the speed at which your skin cells grow and die off, which is a process referred to as skin cell turnover. By increasing the rate of skin cell turnover, tretinoin helps to prevent the buildup of skin cells within the hair follicles on your face. This buildup is what leads to the formation of acne lesions, including whiteheads and blackheads. Therefore, by increasing skin cell turnover, tretinoin helps to prevent these acne lesions from forming.

Together, these two active ingredients work synergistically to treat acne. Clindamycin reduces the number of acne-causing bacteria on the skin, while tretinoin promotes skin cell turnover to prevent the formation of acne lesions.

The gel formulation is designed to be easily applied to the skin. It is dispensed through a pump mechanism, which allows for precise application of the medication to the targeted areas of the skin. The gel-like consistency of the formulation allows for easy spreadability on the skin, ensuring that the active ingredients are evenly distributed for optimal effectiveness.

It's also crucial to use this medication as directed by your healthcare provider, as overuse can lead to skin irritation and may not provide additional benefits.

If you have any questions about the Clindamycin 2%/Tretinoin 0.05% Topical Gel, or if you would like more information about how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Clindamycin 2%/Tretinoin 0.05% Topical Gel, besides being commonly employed to treat skin and acne disorders, may also be used for other skin conditions not listed in the approved professional labeling for the drug. These uses vary, and are off-label; thus, they should be pursued under the discretion of a healthcare provider.

The medication's antibacterial and anti-inflammatory properties, thanks to the clindamycin ingredient, may be useful for treating folliculitis, infections of the hair follicles on the skin. By reducing the proliferation of bacteria, the medication can limit the severity and frequency of folliculitis flare-ups. Nonetheless, the effectiveness for such use would have to be ascertained on a case-by-case basis.

Concurrently, it may be utilized for its anti-wrinkle benefits attributable to the tretinoin content, a form of Vitamin A that aids the speed of cell turnover promoting new skin cell growth and the reduction of wrinkles. However, this use of clindamycin and tretinoin topical gel, for anti-aging purposes, isn't commonly prescribed and formal scientific studies for this particular use are limited.

Besides, this formulation has been used by dermatologists to treat keratosis pilaris, a condition marked by small bumps on the skin. The topical gel aids in unplugging hair follicles and has an exfoliating effect that helps to improve the appearance of the skin affected by this condition.

However, it is crucial to understand that these other uses don't come without potential risks. The gel has been associated with side effects including dryness, scaling, and redness of the skin, which may not be tolerable for every patient. Therefore, it's essential to have these conversations with a knowledgeable healthcare professional who can guide on the risks and benefits in an individual's particular case.

In conclusion, while these applications could represent the versatility of this formulation, it's important to emphasize that they are off-label uses. If you have any questions or need more information about this, don’t hesitate to reach out to us. We are always willing to help.

Frequently Asked Questions

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What is Clindamycin 2%/Tretinoin 0.05% Topical Gel?

Clindamycin 2%/Tretinoin 0.05% Topical Gel is a semisolid formulation containing the active ingredients Clindamycin and Tretinoin which are used for targeted treatment of various skin conditions.

How is the Clindamycin 2%/Tretinoin 0.05% Topical Gel dispensed?

This topical gel is dispensed through a pump mechanism. This design enables easy and precise application on the skin.

How does the gel consistency affect the product usability?

The gel-like consistency of the product ensures a smooth, easy application and enhances the absorption of active ingredients into the skin.

What is the purpose of Clindamycin in the formulation?

Clindamycin is an antibiotic that stops the growth of bacteria that can cause acne, thereby treating the skin condition effectively.

How does Tretinoin contribute to the treatment?

Tretinoin is a form of vitamin A that helps to reduce the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. This aids in the treatment of acne.

How often should I apply this gel?

Use part of your regular skincare routine or as directed by your health care professional. However, excessive usage can lead to dry skin or other side effects, so always follow recommended usage.

Should I worry about applying too much or too little of the gel?

The pump design of the container assists in easy and precise dosing.

Does the gel help with other skin conditions or only acne?

While the primary use of Clindamycin/Tretinoin gel is for the treatment of acne, it may also help improve other skin conditions such as wrinkles and rough skin texture. Always consult a healthcare professional for all treatment plans.

What side effects might I expect from using this gel?

Side effects may include skin irritation, dryness, redness, or peeling, especially in the early stages of treatment. If you experience persistent or severe side effects, stop using the product and reach out to your healthcare provider immediately.

Can I use other skincare products while using this gel?

You can, but it's crucial to consult your doctor or skincare consultant first. Some products may increase skin irritation when used with this gel, especially those containing alcohol, astringents, or lime/menthol.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Clindamycin 2%/Tretinoin 0.05% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)