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Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Estriol
Estradiol
Progesterone

Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel is a specially compounded medication. It is dispensed through a pump mechanism for easy and precise application. This semisolid formulation is designed for targeted treatment or absorption of active ingredients. It is used to treat conditions such as Vulvovaginal Atrophy, Menopausal Symptoms, Uterine Bleeding, Endometriosis, and Dyspareunia.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Get a one-page sheet with everything your doctor needs to prescribe this and send it to Bayview.

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Estriol
Estradiol
Progesterone
Topical Gel
6427079ea64324876f518ac4
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Currently licensed Limited basis, registration pending Not available for this formula Not currently licensed

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Formula Information

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This topical gel formulation is a compounded blend of estriol and estradiol, each constituting 50% of the formulation, with concentrations ranging from 0.05 to 0.5 mg/gm. It also contains progesterone in concentrations ranging from 5 to 50 mg/gm. This unique combination is designed to address a variety of health conditions, including menopausal symptoms, endometriosis, uterine fibroids, and premenstrual syndrome (PMS). It has also been found to potentially reduce the risk of endometrial cancer.

The gel is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The active ingredients are absorbed through the skin and into the bloodstream, providing targeted treatment. The gel-like consistency ensures a smooth application process.

It is crucial to note that this formulation is not suitable for pregnant women or women who are breastfeeding. The active ingredients may cause harm to the fetus or pass into breast milk, potentially causing harm to the infant.

When used as directed, this formulation has been shown to effectively alleviate symptoms such as hot flashes, night sweats, and vaginal dryness. It may also contribute to a reduced risk of developing endometrial cancer and uterine fibroids.

If you have any questions or concerns about this formulation, please do not hesitate to contact us at Bayview Pharmacy. Our team of compounding pharmacists is well-equipped with the knowledge and expertise to assist you.

Drug Interactions

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This compounded formulation of Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm is a topical gel designed for precise application on the skin. It is primarily used for the treatment of menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. It can also be beneficial in treating vulvovaginal atrophy, a condition common in postmenopausal women due to decreased estrogen levels.

Additionally, this formulation may be used in the treatment of endometriosis, a condition where tissue that normally lines the uterus grows outside of it. Certain types of breast cancer in premenopausal women may also be treated with this formulation.

However, it is important to note that this formulation should not be used by women who are pregnant or breastfeeding. Women with a history of stroke, blood clots, or liver disease should also avoid using this product. If you are currently taking other medications, such as anticoagulants, it is crucial to consult your healthcare provider before starting this treatment.

The gel should be applied to the affected area once daily, or as directed by your healthcare provider. Exceeding the recommended dose may increase the risk of side effects.

Common side effects include skin irritation, itching, and redness. If these occur, it is advised to contact your healthcare provider. Rare but serious side effects such as chest pain, shortness of breath, and leg swelling should be treated as medical emergencies and require immediate attention.

If you have any questions or concerns about this formulation, please do not hesitate to reach out to your healthcare provider or pharmacist for further information and guidance.

How Does it Work

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This topical gel is a compounded formulation of estriol and estradiol, each present in a 50/50 ratio, with concentrations ranging from 0.05-0.5 mg/gm. Additionally, it contains progesterone in concentrations of 5-50 mg/gm. This unique combination is designed to address a variety of health conditions, including menopausal symptoms, endometriosis, and uterine fibroids.

Upon application to the skin, the estriol and estradiol components are absorbed into the bloodstream. These hormones work to alleviate menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. The progesterone component of the gel serves to mitigate the risk of endometrial hyperplasia, a condition that can arise when estrogen levels are excessively high. Furthermore, progesterone aids in reducing the symptoms associated with endometriosis and uterine fibroids.

When utilizing this formulation, adherence to the instructions provided by your healthcare provider is crucial. The gel is typically applied to the skin once or twice daily, depending on the severity of the symptoms. It is essential to apply the gel to clean, dry skin, and to avoid contact with the eyes, nose, and mouth. Washing your hands after applying the gel is also recommended.

If you have any queries regarding this formulation or its application, please do not hesitate to contact us.

Frequently Asked Questions

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What is the Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel?

This is a compounded formulation of Estriol, Estradiol, and Progesterone in a semisolid gel form. It is dispensed through a pump mechanism for easy and precise application on the skin.

How does the pump mechanism work?

The pump mechanism allows for easy and precise dispensing of the gel. It ensures that the correct amount of medication is applied each time, reducing the risk of over or under-dosing.

How should I apply this topical gel?

You should apply this gel directly to your skin as directed by your healthcare provider. The pump mechanism allows for easy and precise application.

What is the purpose of the gel-like consistency?

The gel-like consistency allows for targeted treatment or absorption of the active ingredients. It is designed to adhere to the skin and deliver the medication directly to the affected area.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Estriol, Estradiol, and Progesterone. These are hormones that are commonly used in hormone replacement therapy.

What is the concentration of the active ingredients?

The concentration of Estriol and Estradiol is 50% each, ranging from 0.05 to 0.5 mg per gram. The concentration of Progesterone ranges from 5 to 50 mg per gram.

What are the potential side effects of this medication?

As with any medication, there may be potential side effects. These can include skin irritation at the application site, changes in mood or weight, and others. Always consult your healthcare provider for a complete list of potential side effects.

Can I use this medication if I am pregnant or breastfeeding?

It is important to consult your healthcare provider before using this medication if you are pregnant or breastfeeding. They will be able to provide you with the most accurate and up-to-date information.

How should I store this medication?

This medication should be stored at room temperature, away from heat and direct light. Keep it out of reach of children and pets.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Estriol/Estradiol [50%/50%] 0.05-0.5 mg/Gm/Progesterone 5-50 mg/Gm Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)

Once daily