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The Ivermectin 1%/Metronidazole 0.75% Topical Cream is a semisolid preparation that combines the antiparasitic and anti-inflammatory properties of ivermectin with the antibacterial and anti-inflammatory effects of metronidazole. This dual-action cream is dispensed in a pump mechanism, which ensures a convenient, hygienic, and controlled application. The formulation is specifically designed for topical use on the skin to treat localized conditions.
This cream is indicated for the treatment of inflammatory lesions of rosacea, a chronic skin disease characterized by redness, pimples, and, in some cases, thickened skin. Ivermectin effectively reduces the demodex mite population, which is thought to play a role in rosacea, while metronidazole provides its therapeutic effect by reducing inflammation and erythema associated with the condition. The combination of these two active ingredients in a single formulation offers a multifaceted approach to managing the symptoms of rosacea, improving patient outcomes.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Ivermectin 1%/Metronidazole 0.75% Topical Cream is a compounded medication that combines two potent active ingredients, ivermectin and metronidazole, in a semisolid cream base. This formulation is specifically designed to be dispensed in a pump mechanism, which allows for easy, hygienic, and controlled application directly to the affected skin areas. The pump ensures consistent dosing and minimizes the risk of contamination, which is particularly important for patients with compromised skin integrity.
It works by binding to invertebrate muscle and nerve cells of parasites, causing paralysis and death of the parasites. In the context of rosacea, ivermectin has anti-inflammatory properties and helps reduce the number of inflammatory lesions.
Metronidazole, on the other hand, is an antibiotic and antiprotozoal medication that is used to treat a variety of conditions, including bacterial vaginosis, and certain skin disorders such as rosacea. It is believed to work by entering the bacterial and protozoal cells and interfering with their DNA synthesis, ultimately leading to cell death. In rosacea, metronidazole has been shown to reduce inflammation and the number of pustules and papules.
The combination of ivermectin and metronidazole in a single topical formulation provides a multifaceted approach to the treatment of skin conditions that may benefit from both antiparasitic and antibacterial actions. This can be particularly useful in complex skin conditions where both types of microorganisms may be contributing to the disease state. The cream base is designed to be moisturizing and to allow the active ingredients to be absorbed into the skin where they can exert their therapeutic effects.
This compounded medication is intended for use under the guidance of a healthcare provider and is formulated to meet the specific needs of individual patients. It is important for patients to follow the application instructions provided by their healthcare provider to ensure optimal treatment outcomes. Prescribers considering this formulation for their patients can expect a product that addresses multiple mechanisms of action relevant to the treatment of certain skin conditions.
If you have any questions or require further information about the Ivermectin 1%/Metronidazole 0.75% Topical Cream, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support and guidance to both patients and healthcare providers.
The combination of Ivermectin 1% and Metronidazole 0.75% in a topical cream formulation is used primarily for the treatment of certain dermatological conditions. Metronidazole is an antibiotic and antiprotozoal medication that is used to treat bacterial infections, including those affecting the skin, and is also commonly used for the treatment of rosacea.
When using this combination topical cream, it is important to consider potential drug interactions. Although systemic absorption of these agents is low when applied topically, interactions can still occur, particularly with other topical agents or if the skin barrier is compromised. Ivermectin, when used topically, has minimal interactions; however, it is important to avoid concomitant use with other medications that enhance the GABAergic system, such as benzodiazepines or barbiturates, as this could theoretically increase the risk of central nervous system depression if systemic absorption occurs.
Metronidazole, on the other hand, may interact with anticoagulants like warfarin, as it can potentiate their effect and increase the risk of bleeding. Patients should be monitored for signs of bleeding if these medications are used concurrently. Additionally, alcohol should be avoided during treatment and for at least 24 hours after the last application of the cream, as metronidazole can cause a disulfiram-like reaction, resulting in nausea, vomiting, and flushing.
It is also advisable to avoid the use of other topical preparations, especially those containing alcohol or astringents, as they may cause irritation when used with this combination cream. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.
Patients with a known hypersensitivity to either ivermectin or metronidazole should not use this formulation. Caution is also advised when using this cream in patients with severe hepatic impairment, as metronidazole is metabolized by the liver and may accumulate to toxic levels in these individuals.
For any questions or concerns regarding the use of this topical cream or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide you with the necessary information to ensure appropriate treatment.
The Ivermectin 1%/Metronidazole 0.75% Topical Cream is a specially compounded medication that combines two active ingredients, ivermectin and metronidazole, in a semisolid cream base. This formulation is designed to be dispensed from a pump mechanism, which allows for easy, controlled application directly to the affected skin areas. The pump ensures that the medication is dispensed in consistent amounts, promoting uniform application and dosing.
Ivermectin is an antiparasitic agent that works by binding to certain parts of the parasite's nerve and muscle cells, increasing the permeability of the cell membrane to chloride ions. This results in paralysis and death of the parasite. It reduces the inflammatory lesions and erythema associated with the disease by targeting the Demodex mites that are thought to contribute to the condition.
Metronidazole, on the other hand, is an antibiotic and antiprotozoal medication. It is believed to work by entering the bacterial and protozoal cells and interfering with their DNA synthesis, ultimately leading to cell death. It is thought to work through its anti-inflammatory properties and its ability to inhibit reactive oxygen species that contribute to the inflammatory process.
When combined in this topical cream, ivermectin and metronidazole offer a dual approach to treating skin conditions like rosacea. Ivermectin targets the parasitic component, while metronidazole addresses the bacterial aspect and reduces inflammation. This combination can lead to a more comprehensive treatment outcome, improving the appearance of the skin and providing relief from symptoms. The cream base also moisturizes and protects the skin, enhancing the overall therapeutic effect.
It is important for patients and prescribers to understand that this formulation should be used as directed by a healthcare professional. The specific dosing regimen will depend on the individual patient's condition and response to treatment. Consistent use as prescribed is crucial for achieving the best results. If you have any questions or require further information about this formulation and its use in treating skin conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to support you with expert advice and personalized care.
This topical cream is a compounded medication used primarily to treat certain skin conditions such as rosacea, which may include inflammation, redness, and pimples. Ivermectin has anti-parasitic and anti-inflammatory properties, while Metronidazole is an antibiotic that helps to reduce infection and inflammation.
Apply the cream to the affected area as directed by your physician, usually once or twice daily. Before applying, clean the area with a mild cleanser and pat dry. Use the pump to dispense the cream onto your fingertips and spread it gently over the skin. Wash your hands after applying the cream.
Yes, you can wear makeup after applying the Ivermectin 1%/Metronidazole 0.75% Topical Cream. However, it is best to wait until the cream has dried on your skin before applying makeup or other skincare products. This typically takes about 5 to 10 minutes.
If you miss a dose of the cream, apply it as soon as you remember, unless it's close to the time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Side effects can include skin irritation, dryness, redness, burning or stinging sensation, and scaling. If any of these effects persist or worsen, contact your healthcare provider. Severe side effects are rare but report any signs of a serious allergic reaction immediately.
Store the cream at room temperature away from light and moisture. Do not store it in the bathroom. Keep the medication out of reach of children and pets. Consult your pharmacist or the product label for more specific storage instructions.
Avoid contact with eyes, mouth, and other mucous membranes. If the medication gets into these areas accidentally, rinse thoroughly with water. During treatment, you may need to avoid alcohol-containing products, as they can cause irritation when used with Metronidazole.
The safety of Ivermectin 1%/Metronidazole 0.75% Topical Cream during pregnancy or breastfeeding is not fully established. You should use this medication only if clearly needed and after consulting with your healthcare provider.
A mild tingling sensation after applying the cream can be normal, but if it is strong or persistent, or if you experience severe burning or stinging, stop using the medication and consult your healthcare provider for advice.
No, you should not apply Ivermectin 1%/Metronidazole 0.75% Topical Cream on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these conditions have fully healed before using the medication on those areas.
The pump mechanism is designed for convenient and controlled application, ensuring you get the correct dose each time. It also helps in maintaining the cream's sterility by preventing direct contact with the container's contents, which can reduce the risk of contamination.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
