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The Ketamine 11.5%/Lidocaine HCl 10%/Methocarbamol 10% Topical Gel is a specialized semisolid formulation designed for targeted application on the skin. This unique compound combines the analgesic and anesthetic properties of ketamine and lidocaine with the muscle relaxant effects of methocarbamol. The gel is dispensed through a pump mechanism, which ensures easy and precise dosing. The consistency of the gel allows for optimal skin contact and potential absorption of the active ingredients.
This formulation is primarily used in the management of neuropathic pain, a type of chronic pain caused by nerve damage or dysfunction. It may also be beneficial for patients experiencing musculoskeletal pain or spasticity, where muscle relaxation is needed. The combination of active ingredients works synergistically to provide pain relief and muscle relaxation, potentially improving the quality of life for patients suffering from these disease states.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Ketamine 11.5%/Lidocaine HCl 10%/Methocarbamol 10% Topical Gel is a specialized medication compounded by Bayview Pharmacy to provide targeted relief from various conditions. This semisolid formulation is designed to be dispensed through a pump mechanism, which ensures easy and precise application. The gel-like consistency allows for the active ingredients to be absorbed through the skin, directly reaching the affected area.
Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, Ketamine at 11.5% works to provide pain relief by blocking NMDA receptors, which are involved in pain transmission and modulation. This can be particularly beneficial for patients experiencing neuropathic pain, a type of chronic pain caused by nerve damage.
Lidocaine HCl, a local anesthetic, is included at a 10% concentration. It works by blocking sodium channels, which temporarily interrupts the path of pain signals along nerves. This can provide symptomatic relief from pain, including that associated with conditions like post-herpetic neuralgia or other forms of localized pain.
Methocarbamol, a muscle relaxant, is incorporated at a 10% concentration to help alleviate muscle spasms and associated pain. This can be especially useful in the treatment of musculoskeletal conditions, such as back pain or strains, where muscle spasms are a common symptom.
This compounded gel is intended for patients who require a multimodal approach to pain management, particularly when oral medications are not suitable or have not provided adequate relief. It is also beneficial for those who prefer a non-systemic treatment option with potentially fewer side effects. The combination of an NMDA receptor antagonist, a local anesthetic, and a muscle relaxant in a topical formulation allows for a synergistic effect, targeting different pain pathways and providing comprehensive pain management.
Patients and prescribers considering this formulation should be aware of the potential side effects and contraindications associated with each active ingredient. It is important to use this medication as directed by a healthcare professional and to discuss any concerns or questions with the compounding pharmacists at Bayview Pharmacy. For further information or guidance on the use of this topical gel, please do not hesitate to reach out to us.
The topical gel formulation containing Ketamine 11.5%, Lidocaine HCl 10%, and Methocarbamol 10% is designed for localized application and is intended to provide analgesic and muscle relaxant effects directly to the area of application. However, it is important to consider potential drug interactions when using this formulation, especially if the patient is taking other medications systemically or applying other topical treatments.
Ketamine, a NMDA receptor antagonist, is primarily metabolized by the liver enzyme CYP3A4. While systemic absorption of ketamine from topical application is expected to be low, concurrent use of systemic medications that are strong inhibitors or inducers of CYP3A4 could potentially affect the metabolism of ketamine if significant systemic absorption occurs. Examples of such medications include certain antifungals, macrolide antibiotics, and anticonvulsants. Additionally, ketamine may have additive CNS depressant effects when used with other CNS depressants such as benzodiazepines, opioids, or alcohol.
Lidocaine is an amide local anesthetic and antiarrhythmic agent. It is metabolized by the liver enzymes CYP1A2 and CYP3A4. Similar to ketamine, the systemic absorption of lidocaine from a topical application is generally minimal, but the use of systemic medications that affect these enzymes could alter lidocaine metabolism if significant systemic absorption occurs. Caution is advised when using other local anesthetics or antiarrhythmic agents concurrently, as this may increase the risk of systemic toxicity, including CNS and cardiovascular effects.
Methocarbamol is a muscle relaxant that works centrally and does not directly relax tense skeletal muscles. While there is limited information on the metabolism of topically applied methocarbamol, systemic methocarbamol is metabolized in the liver and excreted primarily in the urine. The use of methocarbamol in combination with other CNS depressants may enhance the overall sedative effect. Additionally, caution should be exercised when methocarbamol is used with medications that have the potential for hepatic metabolism interference.
It is also important to consider the potential for pharmacodynamic interactions. The combination of ketamine, lidocaine, and methocarbamol in a topical formulation may produce additive effects in terms of analgesia and muscle relaxation. This could be beneficial in treating localized pain and muscle spasms, but the risk of systemic effects, such as sedation and CNS depression, should be monitored, especially in patients with compromised skin integrity or when applied over a large surface area.
Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs, herbal supplements, and other topical treatments, to assess for potential interactions. Prescribers should carefully evaluate the patient's medication profile for interactions before recommending this topical gel formulation. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for assistance.
The Ketamine 11.5%/Lidocaine HCl 10%/Methocarbamol 10% Topical Gel is a compounded medication designed to deliver its active ingredients directly to the site of pain or discomfort. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the medication stays where it is applied and facilitates absorption through the skin.
Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, ketamine works by blocking NMDA receptors, which are involved in pain transmission and modulation. By doing so, it can help reduce central sensitization, which is a condition where the central nervous system becomes sensitized to pain stimuli, often leading to chronic pain states.
Lidocaine HCl is a local anesthetic that works by blocking sodium channels, which are necessary for the conduction of nerve impulses. When applied topically, lidocaine can provide localized pain relief by numbing the area where it is applied. This can be particularly beneficial for patients with localized neuropathic pain or for numbing a painful area due to injury or inflammation.
Methocarbamol is a muscle relaxant that works by depressing the central nervous system, leading to a reduction in muscle spasms. When included in this topical formulation, methocarbamol can help alleviate muscle pain and stiffness, making it useful for conditions such as muscle strains, sprains, and other musculoskeletal conditions.
The combination of these three active ingredients in a topical gel form allows for targeted therapy with potentially fewer systemic side effects compared to oral administration. This can be particularly advantageous for patients who may be sensitive to oral medications or those who prefer localized treatment. The conditions that may benefit from this formulation include neuropathic pain, fibromyalgia, localized muscle pain, and certain types of chronic pain syndromes.
It is important for both patients and prescribers to understand that this is a specially compounded medication and should be used under the guidance of a healthcare professional. The effectiveness and safety of this formulation are based on the proper selection of patients and adherence to application instructions. If you have any questions or require further information about this compounded medication, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to support you with your healthcare needs.
This compounded gel is formulated to manage localized pain, provide analgesic effects, and relax muscles. It contains active ingredients Ketamine, Lidocaine, and Methocarbamol, which work together to help manage symptoms associated with various conditions such as neuropathic pain, muscle spasms, and other pain-related issues.
To apply the gel, press the pump to dispense a small amount onto your fingertips and then gently rub it onto the affected area of your skin. Ensure the area is clean and dry before application. Use the gel as directed by your healthcare provider. Avoid contact with eyes, mouth, and mucous membranes.
The frequency of use for the compounded gel should be determined by your healthcare provider based on your specific condition and severity of symptoms. Do not exceed the recommended dosage without consulting your healthcare provider.
Before using this compounded gel with other medications, consult with your healthcare provider or pharmacist. They can advise you on any potential drug interactions and ensure safe and appropriate use of concurrent treatments.
Side effects can include skin irritation at the application site, temporary numbness or tingling, and allergic reactions. Systemic side effects are less common with topical application, but can occur if large amounts are used or if the gel is applied to broken skin. Contact your healthcare provider if you experience any unusual symptoms.
The safety and effectiveness of this compounded gel in children have not been established. Use in pediatric patients should only be considered if the potential benefits outweigh the risks, and as prescribed by a pediatrician or healthcare provider.
After applying the gel, you should wait for it to dry before covering the area with any clothing or bandages. Consult with your healthcare provider about the use of occlusive dressings, as they may increase the absorption of the active ingredients.
If the pump mechanism is not working, ensure the pump is primed by pressing it several times. If it still fails to dispense the gel, please contact your pharmacist for assistance or further instructions.
The compounded gel should be stored at room temperature, away from direct sunlight and heat. Keep the pump bottle closed when not in use, and store it in a place that is out of reach of children and pets.
If you miss a dose, apply the gel as soon as you remember, unless it is almost time for your next scheduled dose. If you apply too much, wipe off the excess gel with a tissue, and contact your healthcare provider if you have any concerns or experience adverse reactions.
This compounded gel may be used as part of a treatment plan for chronic pain, depending on the individual’s specific condition and healthcare provider's advice. It is important to follow the prescribed treatment regimen and attend regular check-ups to assess effectiveness and adjust treatment as needed.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
