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The Ketamine HCl 10%/Lidocaine HCl 4% Transdermal Gel is a specialized medication designed for the management of neuropathic pain and chronic pain conditions. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application directly to the skin. The gel-like consistency ensures that the active ingredients, ketamine and lidocaine, are absorbed at the site of pain for targeted relief. Ketamine, an NMDA receptor antagonist, and lidocaine, a local anesthetic, work synergistically to reduce pain signaling and provide analgesic effects. This transdermal gel is particularly useful for patients who require localized pain management without the systemic side effects associated with oral medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Ketamine HCl 10%/Lidocaine HCl 4% Transdermal Gel is a compounded medication designed for topical application. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise dosing. The gel base facilitates the transdermal delivery of the active ingredients, ketamine and lidocaine, directly to the site of pain or discomfort. Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to provide analgesic effects, particularly in neuropathic pain conditions. Lidocaine, a local anesthetic, works by blocking sodium channels, thereby reducing pain signaling at the peripheral level. The combination of these two agents in a transdermal gel form offers a synergistic approach to pain management, potentially reducing the need for systemic analgesics.
This formulation is particularly useful in the management of chronic pain syndromes, including neuropathic pain, complex regional pain syndrome (CRPS), and fibromyalgia. It may also be beneficial for patients experiencing localized pain from conditions such as postherpetic neuralgia or musculoskeletal disorders. The transdermal route of administration provides a targeted therapy with a lower risk of systemic side effects compared to oral medications. Additionally, the gel formulation is designed to minimize skin irritation and is suitable for patients who may have difficulties with oral dosing or those who require localized pain relief.
Patients and prescribers should be aware that this is a customized medication prepared in a compounding pharmacy, and its use should be based on a thorough evaluation of the patient's medical history and current medications to avoid potential drug interactions. The efficacy and safety profile of this compounded formulation are based on the known pharmacological actions of the individual ingredients, and its use should be monitored by a healthcare professional. For any questions or concerns regarding this formulation, or to discuss its appropriateness for specific patients, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide additional information and support to ensure optimal treatment outcomes.
The combination of Ketamine HCl 10% and Lidocaine HCl 4% in a transdermal gel is designed to provide analgesic effects when applied topically. Ketamine is an NMDA receptor antagonist that can help manage pain by reducing central sensitization, while Lidocaine is a local anesthetic that blocks sodium channels, leading to a decrease in pain signaling. This formulation is often used for the management of neuropathic pain, localized chronic pain, and in some cases, for the symptomatic relief of certain types of dermatological pain syndromes.
When considering the use of this transdermal gel, it is important to be aware of potential drug interactions. Ketamine is metabolized primarily by the cytochrome P450 enzyme CYP3A4. Therefore, concomitant use with strong inhibitors of CYP3A4 (such as clarithromycin, ketoconazole, or ritonavir) may increase plasma concentrations of ketamine, potentially leading to enhanced effects and side effects. Conversely, strong inducers of CYP3A4 (such as rifampin, carbamazepine, or phenytoin) may decrease ketamine levels, reducing its efficacy.
Lidocaine is also metabolized by cytochrome P450 enzymes, including CYP1A2 and CYP3A4. Similar interactions as those described for ketamine may occur with lidocaine. Additionally, caution should be exercised when lidocaine is used with other local anesthetics or antiarrhythmic drugs due to the additive systemic effects on cardiac conduction and potential toxicity.
Both ketamine and lidocaine may have CNS depressant effects, which can be potentiated when used with other CNS depressants such as opioids, benzodiazepines, or alcohol. This can increase the risk of sedation, respiratory depression, and other CNS-related side effects. Patients should be advised to avoid or limit the use of alcohol and other CNS depressants while using this medication.
It is also important to consider the potential for additive or synergistic effects on blood pressure when ketamine is used with antihypertensive medications or substances that can alter blood pressure. Blood pressure should be monitored, and dosage adjustments may be necessary.
Given the complexity of drug interactions, prescribers should review the patient's current medication regimen in detail to identify any potential interactions before prescribing this transdermal gel. Patients should be instructed to inform their healthcare provider of all medications they are taking, including over-the-counter drugs, herbal supplements, and vitamins, to ensure safe use of this formulation.
For any questions or concerns regarding this formulation or its potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to provide guidance and support to ensure the safe and appropriate use of this medication.
The Ketamine HCl 10%/Lidocaine HCl 4% Transdermal Gel is a specialized medication designed for topical application to provide localized relief from pain. This formulation combines two potent anesthetics: ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, and lidocaine, a sodium channel blocker. When applied to the skin, this gel works by penetrating the dermal layers to reach the underlying tissues where pain receptors are located.
Ketamine, as part of this compound, works by blocking the NMDA receptors in the central nervous system. This action inhibits the transmission of pain signals to the brain, thereby reducing the sensation of pain. Ketamine's role in this formulation is particularly beneficial for neuropathic pain, which is often resistant to other types of pain medication. By targeting the NMDA receptors, ketamine can help alleviate the complex mechanisms involved in neuropathic pain syndromes.
This blockade prevents the initiation and conduction of nerve impulses, leading to a temporary loss of sensation in the applied area.
The combination of ketamine and lidocaine in a transdermal gel allows for a synergistic effect, enhancing the analgesic properties of each drug while minimizing systemic absorption and potential side effects. This makes the formulation an excellent choice for patients experiencing localized pain, such as that associated with conditions like neuropathies, post-herpetic neuralgia, or complex regional pain syndrome (CRPS).
The semisolid formulation of this gel is designed to be dispensed through a pump mechanism, which ensures a consistent and measured dose with each application. This delivery system allows patients to apply the medication directly to the affected area, providing targeted relief. The gel-like consistency facilitates absorption through the skin, ensuring that the active ingredients reach the site of pain without the need for systemic distribution that could lead to unwanted side effects.
For prescribers considering this formulation for their patients, it is important to note that the transdermal route of administration offers a convenient and non-invasive option for pain management. It is suitable for patients who may have difficulty with oral medications or those who require localized pain control without the risks associated with systemic analgesics.
If you have any questions about the Ketamine HCl 10%/Lidocaine HCl 4% Transdermal Gel or its suitability for treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the information and support you need to make informed decisions about pain management options for your patients.
This is a prescription medication that combines two active pharmaceutical ingredients: Ketamine Hydrochloride at a concentration of 10% and Lidocaine Hydrochloride at a concentration of 4%. It is designed for transdermal (through the skin) delivery, providing targeted relief at the site of application.
To use the transdermal gel, apply a thin layer to the affected area as directed by your healthcare provider. The semisolid formulation is dispensed through a pump mechanism, which allows for precise dosing and easy application directly to the skin.
This gel is intended for patients who have been prescribed this specific medication by their healthcare provider for the management of pain or as part of a pain management regimen. It should only be used under the supervision of a healthcare professional.
While the gel may provide relief for various types of pain, it should only be used for conditions for which it has been prescribed. The combination of Ketamine and Lidocaine is often used for neuropathic pain or certain chronic pain conditions but should not be used without professional medical advice.
The frequency of application will depend on the instructions provided by your healthcare provider. It is important to follow their recommendations and not to exceed the prescribed dose.
Possible side effects may include local skin irritation, redness, itching, or a rash at the site of application. Systemic side effects may also occur but are less common. If you experience any concerning symptoms or reaction, contact your healthcare provider immediately.
The medication should be stored at room temperature, away from direct sunlight and heat. Keep the bottle securely closed when not in use, and keep out of reach of children and pets.
Do not cover the treated area with a bandage or dressing unless directed by your healthcare provider, as this might change the absorption of the medication.
If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for the missed dose.
As with any medication, there may be potential interactions with other drugs. Inform your healthcare provider about all other medications, supplements, and remedies you are using to ensure appropriate treatment.
Avoid exposure to heat, such as using a heating pad, on the area where the gel has been applied, as this might increase absorption. Additionally, avoid getting the medication in your eyes, mouth, and other mucous membranes. If contact occurs, rinse thoroughly with water.
The safety of this medication has not been fully established during pregnancy or breastfeeding. It is crucial to discuss the risks and benefits with your healthcare provider before starting treatment if you are pregnant or planning to become pregnant, or if you are breastfeeding.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
