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The Ketamine HCl 11.5% Transdermal Gel is a semisolid formulation designed for targeted application on the skin. This gel is dispensed through a pump mechanism, which ensures easy and precise dosing. The consistency of the gel allows for the ketamine to be absorbed through the skin, providing localized or systemic effects depending on the site of application.
This formulation is commonly used in the management of chronic pain, including neuropathic pain, and may also be utilized in the treatment of complex regional pain syndrome (CRPS).
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Ketamine HCl 11.5% Transdermal Gel is a specialized medication formulated by the compounding pharmacists at Bayview Pharmacy to deliver the active ingredient, ketamine hydrochloride, through the skin directly to the site of pain or discomfort. This semisolid formulation is designed to be dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose with each use. The gel-like consistency of the medication allows for easy application and adherence to the skin, facilitating the absorption of ketamine HCl into the local tissue.
When applied transdermally, ketamine HCl bypasses the gastrointestinal system, potentially reducing systemic side effects and providing targeted relief. This mode of administration is particularly beneficial for patients who may have difficulty with oral medications or those who require localized pain management.
The 11.5% concentration of ketamine HCl in the gel has been carefully chosen to balance efficacy with tolerability. This formulation is commonly used in the treatment of neuropathic pain, a type of chronic pain caused by nerve damage or a malfunctioning nervous system. Conditions such as postherpetic neuralgia, complex regional pain syndrome (CRPS), and certain types of cancer-related pain may respond favorably to this treatment. Additionally, ketamine's potential anti-inflammatory and antidepressant effects can be advantageous in the context of chronic pain, which often has a multifactorial nature.
Patients and prescribers considering Ketamine HCl 11.5% Transdermal Gel should be aware of the importance of proper dosing and application. The pharmacists at Bayview Pharmacy are available to provide guidance on the use of this medication, including instructions for application, dosing schedules, and potential side effects. It is crucial to use this medication under the supervision of a healthcare provider who can monitor its effectiveness and make any necessary adjustments to the treatment plan.
For those interested in exploring the potential benefits of Ketamine HCl 11.5% Transdermal Gel for managing chronic pain, the team at Bayview Pharmacy is ready to assist. We encourage patients and prescribers to reach out to us with any questions or concerns regarding this formulation. Our goal is to support our patients' health and well-being through personalized medication solutions.
Ketamine HCl is a medication primarily known for its anesthetic and analgesic properties. When formulated as an 11.5% transdermal gel, it is intended for topical application and can be used to manage chronic pain, including neuropathic pain. The transdermal route allows for localized effect with potentially reduced systemic side effects. However, it is important to consider potential drug interactions when using this formulation.
Firstly, ketamine is metabolized primarily by the liver enzyme CYP3A4. Therefore, concurrent use of CYP3A4 inhibitors such as clarithromycin, ketoconazole, or grapefruit juice can increase the levels of ketamine, potentially leading to enhanced effects and side effects. Conversely, CYP3A4 inducers like rifampin, carbamazepine, and St. John's Wort may decrease ketamine levels, reducing its efficacy.
Additionally, ketamine has CNS depressant effects. Using it in conjunction with other CNS depressants such as benzodiazepines, opioids, or alcohol can enhance sedation and respiratory depression. This is particularly important to monitor in patients with a history of respiratory issues or when using high doses of CNS depressants.
Antihypertensive medications may also interact with ketamine. Since ketamine can cause increases in blood pressure and heart rate, it may antagonize the effects of antihypertensive drugs, necessitating close monitoring of blood pressure in patients using both types of medications.
Furthermore, ketamine may interact with serotonergic drugs, such as SSRIs, SNRIs, and MAOIs, potentially leading to serotonin syndrome, a serious condition characterized by symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Caution is advised when co-administering these medications.
It is also important to consider the potential for additive or synergistic effects when ketamine is used with other topical medications. The absorption and effect of ketamine may be altered when applied to areas treated with other topical agents, particularly those that affect skin permeability or those with irritant properties.
Patients should be advised to inform their healthcare providers of all medications, supplements, and herbal products they are taking to avoid potential interactions. Prescribers should carefully evaluate the patient's medication profile for potential interactions before prescribing ketamine transdermal gel.
Lastly, due to the potential for abuse and diversion, ketamine should be prescribed and dispensed with caution. Patients should be educated on the proper use and storage of the medication to minimize risks.
If you have any questions or require further information regarding drug interactions with Ketamine HCl 11.5% Transdermal Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team is committed to ensuring the safe and appropriate use of this medication.
The Ketamine HCl 11.5% Transdermal Gel is a specialized medication designed for transdermal delivery, meaning it is absorbed through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise dosing. The gel is applied directly to the skin, where it is intended to provide localized or systemic therapeutic effects.
The active ingredient in this formulation is Ketamine Hydrochloride (HCl), a compound that is well-known for its anesthetic and analgesic properties. At a concentration of 11.5%, the ketamine in the gel works by blocking N-methyl-D-aspartate (NMDA) receptors in the nervous system. This action can help to modulate pain signals and provide relief from various types of chronic pain. Additionally, ketamine has been shown to have anti-inflammatory effects, which may contribute to its pain-relieving properties.
When applied to the skin, the gel's base facilitates the absorption of ketamine into the systemic circulation or to the targeted tissue. The transdermal route of administration can be particularly beneficial for patients who have difficulty swallowing pills or for those who require a steady release of medication over time. This can lead to a reduction in peak-trough fluctuations that are common with oral or injectable dosing, potentially minimizing side effects and improving overall efficacy.
This transdermal gel is used to treat various disease states, particularly chronic pain conditions such as neuropathic pain, complex regional pain syndrome (CRPS), and fibromyalgia. It may also be beneficial for patients with refractory pain who have not responded to other treatments. The localized delivery system aims to reduce systemic side effects and provide targeted relief at the site of pain.
The formulation's strength and dosing regimen should be individualized based on the patient's specific condition, severity of symptoms, and response to therapy. Additionally, patients should be monitored for any potential side effects, such as skin irritation at the application site or systemic effects related to ketamine absorption.
If you have any questions about the Ketamine HCl 11.5% Transdermal Gel or its use in treating various disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary information and support to ensure appropriate treatment for our patients.
Ketamine HCl 11.5% Transdermal Gel is a medicated gel that contains 11.5% of Ketamine Hydrochloride. It is designed to be applied to the skin where it releases the active ingredient over time for targeted treatment.
The gel is applied topically to the skin. Use the pump mechanism to dispense the recommended amount of gel, and gently spread it onto the area of skin as directed by your healthcare provider. Always follow the prescribed dosage and instructions.
The pump mechanism is designed to provide an easy and precise way to dispense a consistent dose of the medication with each application, ensuring accurate dosing and reducing the potential for waste or overdose.
No, Ketamine HCl 11.5% Transdermal Gel is a specific medication that should only be used for conditions prescribed by your healthcare provider. It is not suitable for all skin conditions.
The safety of Ketamine HCl 11.5% Transdermal Gel for all ages has not been established. Always consult with a healthcare provider before using this medication, particularly in children or the elderly.
The frequency of application will depend on your healthcare provider's instructions. It is important to follow their guidance and not to alter the dosing schedule without consultation.
You should avoid applying Ketamine HCl 11.5% Transdermal Gel to broken or irritated skin unless specifically instructed by your healthcare provider, as it may lead to increased absorption or side effects.
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and apply the next one at the regular time. Do not apply extra gel to make up for a missed dose.
As with any medication, side effects are possible. These can include local reactions such as skin irritation, redness, or rash. Systemic effects, although rare in transdermal delivery, may occur and you should contact your healthcare provider if you experience any unusual symptoms.
Unless directed by your healthcare provider, it is typically not necessary to cover the treated skin area. Covering can alter the absorption of the medication. If you have been advised to cover the area, follow those specific instructions.
Store the medication at room temperature, away from heat and direct sunlight. Keep the container tightly closed when not in use. Keep out of reach of children and pets.
It is best to avoid using other skincare products on the application area unless your healthcare provider approves their use. Other products may interfere with the absorption or action of the medication.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
