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The Ketoprofen 20%/Ibuprofen 2.5% Transdermal Gel is a specialized semisolid formulation designed for targeted delivery of anti-inflammatory and analgesic medication directly through the skin. This gel is dispensed from a pump mechanism, which ensures ease of use and precise dosing. The unique combination of ketoprofen and ibuprofen in the gel base offers synergistic effects for the management of pain and inflammation.
This transdermal gel is primarily indicated for the treatment of localized musculoskeletal pain, osteoarthritis, and rheumatoid arthritis. It may also be used to alleviate soft tissue inflammation, such as tendinitis and bursitis, providing patients with a non-invasive treatment option that minimizes systemic exposure to the medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Ketoprofen 20%/Ibuprofen 2.5% Transdermal Gel is a specialized medication designed for topical application. This semisolid formulation is dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose of the medication directly to the affected area. The gel base provides a suitable medium for the transdermal delivery of the active ingredients, ketoprofen and ibuprofen, which are both nonsteroidal anti-inflammatory drugs (NSAIDs).
Ketoprofen is a potent analgesic and anti-inflammatory agent that works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins, substances that mediate inflammation and pain. Ibuprofen, similarly, exerts its effects by reducing the production of prostaglandins. The combination of these two NSAIDs in a transdermal gel allows for localized relief of pain and inflammation with a reduced systemic exposure, potentially minimizing gastrointestinal side effects commonly associated with oral NSAIDs.
This formulation is particularly useful in the treatment of localized musculoskeletal conditions such as arthritis, tendinitis, bursitis, and other inflammatory disorders. By applying the gel directly to the skin over the affected area, patients may experience prompt relief from pain and swelling. The transdermal route also offers the advantage of bypassing the first-pass metabolism in the liver, which can lead to higher local drug concentrations and prolonged therapeutic effects.
Patients should be advised to use the medication as directed by their healthcare provider, and not to exceed the recommended dose or frequency of application. It is important to apply the gel to clean, intact skin and to avoid contact with eyes, mucous membranes, or open wounds. Patients should also be informed that while the transdermal gel reduces systemic absorption, systemic side effects, although less likely, are still possible and they should monitor for signs of NSAID-related adverse effects.
Prescribers considering this formulation for their patients should assess the suitability based on the patient's medical history, concomitant medications, and the potential for drug interactions. Monitoring for therapeutic effectiveness and adverse reactions is recommended during the course of treatment. As with all medications, patient education on the proper use and storage of the transdermal gel is crucial for ensuring safety and efficacy.
If you have any questions or require further information about the Ketoprofen 20%/Ibuprofen 2.5% Transdermal Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support to both patients and healthcare providers.
The combination of ketoprofen and ibuprofen in a transdermal gel formulation is designed to provide anti-inflammatory and analgesic effects directly to the site of application. Both ketoprofen and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins, substances that mediate inflammation and pain. While this combination may offer the benefit of localized action with potentially reduced systemic side effects, it is important to consider potential drug interactions when using this formulation.
Concomitant use of other NSAIDs, including over-the-counter medications such as aspirin, naproxen, or other topical NSAIDs, should be avoided as this may increase the risk of adverse effects, including gastrointestinal ulceration, bleeding, and renal impairment. Patients should also be cautious when combining this gel with anticoagulants (such as warfarin), antiplatelet agents (such as clopidogrel), or selective serotonin reuptake inhibitors (SSRIs), as these can further increase the risk of bleeding.
Patients taking angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or diuretics should be monitored closely, as NSAIDs can reduce the antihypertensive effect of these drugs and may lead to the deterioration of renal function. The use of this transdermal gel in combination with corticosteroids or alcohol may also increase the risk of gastrointestinal side effects. Additionally, caution is advised when used with methotrexate or lithium, as NSAIDs can elevate plasma levels of these drugs, potentially leading to toxicity.
It is important to note that while the transdermal route of administration may reduce systemic exposure, systemic absorption can still occur, and the potential for drug interactions exists. Patients should inform their healthcare provider of all medications they are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to assess for potential interactions.
This transdermal gel formulation is intended for the treatment of localized pain and inflammation, such as that associated with musculoskeletal conditions like arthritis, tendinitis, or bursitis. It is not intended for the treatment of systemic inflammatory conditions or pain. The use of this gel should be limited to the affected area, and it should not be applied to open wounds, damaged skin, or mucous membranes.
If you have any questions or require further information regarding this formulation and its potential interactions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and appropriate use of this medication.
The Ketoprofen 20%/Ibuprofen 2.5% Transdermal Gel is a specialized medication designed for topical application to provide localized relief from pain and inflammation. This semisolid formulation is dispensed through a pump mechanism, which ensures that patients can apply a consistent and precise dose of the medication directly to the affected area. The gel base facilitates the penetration of the active ingredients through the skin, allowing for targeted action and potentially reducing systemic side effects compared to oral administration.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in the inflammation process. By reducing their production, ketoprofen effectively decreases inflammation and pain in the tissues where the gel is applied. The 20% concentration of ketoprofen in this formulation is intended to provide a high level of anti-inflammatory action and analgesia directly at the site of application.
Ibuprofen, another NSAID with a similar mechanism of action, works synergistically with ketoprofen to enhance the anti-inflammatory and analgesic effects. At a concentration of 2.5%, ibuprofen contributes to the overall efficacy of the gel without significantly increasing the risk of local or systemic side effects that can be associated with higher doses of NSAIDs. The combination of these two NSAIDs in a transdermal gel form is particularly useful for treating localized musculoskeletal conditions, such as sprains, strains, and arthritis-related pain.
The transdermal delivery system of this gel offers several advantages. It allows the medication to bypass the gastrointestinal tract, reducing the risk of gastrointestinal irritation or ulcers that can occur with oral NSAIDs. Additionally, the localized application minimizes the amount of drug that enters the systemic circulation, potentially reducing the risk of systemic side effects such as renal impairment or cardiovascular issues that are sometimes associated with NSAIDs.
Patients and prescribers should note that while this formulation is designed for targeted delivery, it is still important to use it as directed to minimize the risk of adverse effects. The gel should be applied to intact skin only and should not be used on open wounds or in conjunction with occlusive dressings unless advised by a healthcare professional. As with all medications, individual responses can vary, and it is important to monitor for any signs of local or systemic reactions.
For those interested in using the Ketoprofen 20%/Ibuprofen 2.5% Transdermal Gel, or for more detailed information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is available to answer any questions and provide guidance on the appropriate use of this medication.
This medication is a compounded transdermal gel that combines two anti-inflammatory drugs, Ketoprofen at a concentration of 20% and Ibuprofen at 2.5%. It's designed to be applied topically to provide targeted relief from pain and inflammation.
To use this gel, apply it directly to the affected area of your skin as prescribed by your healthcare provider. The pump mechanism allows for easy dispensing and precise dosing. Rub it gently into the skin for maximum absorption.
Follow your healthcare provider's instructions regarding usage frequency, as it can vary based on your condition and response to treatment. Do not apply more often than prescribed, as this can increase the risk of side effects.
This gel is primarily intended for relieving pain and inflammation associated with conditions like arthritis, tendinitis, or sports injuries. Consult your healthcare provider for your specific condition to determine if this medication is appropriate for you.
Possible side effects include localized skin irritation, redness, itching, or rash. Systemic side effects are less common with topical application than with oral forms, but if you experience any unusual symptoms, contact your healthcare provider immediately.
Avoid covering the treated area with airtight dressings such as bandages unless your healthcare provider instructs you to do so, as this might increase the absorption of the medication and potentially lead to more side effects.
If you miss a dose, apply the gel as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Store the gel at room temperature, away from direct heat and light. Keep the bottle properly closed and out of reach of children. If the medication has expired or is no longer needed, dispose of it as instructed by your pharmacist.
The safety of this gel during pregnancy or breastfeeding has not been fully established. Always consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or are breastfeeding.
You should avoid using other topical products on the same area without first consulting your healthcare provider, as there may be a risk of interactions or increased side effects.
Avoid exposing the treated area to sunlight or UV lamps, as certain ingredients in the gel may increase your skin's sensitivity to sunlight. Also, avoid applying heat to the treated area, such as heating pads or hot water bottles, unless instructed by your healthcare provider.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
