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Amitriptyline HCl 5%/Bupivacaine HCl 2%/Gabapentin 5%/Ketoprofen 20% Topical Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Amitriptyline Hydrochloride
Bupivacaine Hydrochloride
Gabapentin
Ketoprofen

This formulation is a compounded topical gel containing Amitriptyline HCl 5%, Bupivacaine HCl 2%, Gabapentin 5%, and Ketoprofen 20%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant used for its analgesic properties, Bupivacaine HCl is a local anesthetic, Gabapentin is used for neuropathic pain relief, and Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic and anti-inflammatory properties.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Bupivacaine Hydrochloride
Gabapentin
Ketoprofen
Topical Gel
6530aa8737a36ef8301e0746
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 5%, Bupivacaine HCl 2%, Gabapentin 5%, and Ketoprofen 20%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the targeted area for optimal therapeutic effect.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. Bupivacaine HCl is a local anesthetic that provides numbness or loss of feeling in the area where the gel is applied. It works by blocking nerve signals in your body, thus reducing pain sensation.

Gabapentin is an anticonvulsant and nerve pain medication. It is used in this formulation for its ability to treat nerve pain by changing the way the body senses pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It is used in this formulation for its potent anti-inflammatory and analgesic effects.

This compounded formulation is typically used to manage pain in various disease states. It can be beneficial for patients suffering from neuropathic pain conditions, such as postherpetic neuralgia and diabetic neuropathy. It may also be used for localized pain management in conditions like osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders. The combination of these four active ingredients provides a multi-modal approach to pain management, targeting different aspects of pain perception and inflammation.

As with any medication, it is important to use this formulation as directed by your healthcare provider. Side effects may include skin irritation at the application site, dizziness, drowsiness, or dry mouth. If any of these effects persist or worsen, or if you experience any serious side effects, contact your healthcare provider immediately.

Remember, this is a compounded medication, specifically tailored to meet individual patient needs. It is not intended to replace any existing medication regimen, but rather to provide an additional tool for managing difficult-to-treat pain conditions. Always consult with your healthcare provider before starting any new medication.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Drug Interactions

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This compounded formulation contains Amitriptyline HCl, Bupivacaine HCl, Gabapentin, and Ketoprofen. Each of these active ingredients can interact with other medications, potentially altering their effects. It's crucial to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Amitriptyline HCl, a tricyclic antidepressant, can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive drugs. Combining these medications can lead to serious side effects such as serotonin syndrome, increased heart rate, and elevated blood pressure. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

Bupivacaine HCl, a local anesthetic, can interact with certain antiarrhythmic drugs (like lidocaine and mexiletine), beta-blockers, and other local anesthetics. These interactions can lead to additive systemic toxicity, including CNS effects and cardiovascular effects.

Gabapentin, an anticonvulsant, can interact with antacids containing magnesium or aluminum, morphine, and certain stomach acid reducing drugs. These interactions can affect the absorption of gabapentin, potentially reducing its effectiveness. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with anticoagulants, antiplatelet drugs, corticosteroids, and certain antihypertensive drugs. These interactions can increase the risk of gastrointestinal bleeding and may affect kidney function. It's also important to avoid alcohol while using this medication as it can increase the risk of stomach bleeding.

This formulation is designed to provide targeted treatment for a variety of conditions, including neuropathic pain, inflammation, and certain types of arthritis. The combination of these active ingredients works synergistically to provide pain relief, reduce inflammation, and improve nerve function. However, it's important to use this medication exactly as directed by your healthcare provider to ensure its safety and effectiveness.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us.

How Does it Work

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This formulation is a combination of four active ingredients: Amitriptyline HCl, Bupivacaine HCl, Gabapentin, and Ketoprofen, each playing a unique role in managing pain and inflammation.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, and the body's response to pain. In this topical formulation, it can help to reduce nerve pain at the site of application.

Bupivacaine HCl is a local anesthetic. It works by blocking nerve impulses in your body, thereby reducing pain and discomfort. When applied topically, it numbs the skin and underlying tissues, providing immediate relief from pain.

Gabapentin is an anticonvulsant and nerve pain medication. It works by calming down nerve activity, thus reducing pain sensations. In a topical formulation, it can help to manage neuropathic pain directly at the site of application.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. When applied topically, it can help to reduce inflammation and pain in the muscles and joints.

The combination of these four active ingredients in a gel formulation allows for targeted treatment. The gel is easily applied to the skin, and the active ingredients are absorbed directly into the affected area.

This formulation can be used to treat a variety of disease states that involve pain and inflammation, including neuropathic pain, musculoskeletal pain, and inflammatory conditions. It can also be used to manage pain associated with conditions such as fibromyalgia, post-herpetic neuralgia, and diabetic neuropathy.

As with any medication, it's important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

Frequently Asked Questions

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What is Amitriptyline HCl 5%/Bupivacaine HCl 2%/Gabapentin 5%/Ketoprofen 20% Topical Gel?

This is a compounded formulation that combines Amitriptyline HCl, Bupivacaine HCl, Gabapentin, and Ketoprofen. It's dispensed as a semisolid gel through a pump mechanism, allowing for easy and precise application on the skin.

How should I use this medication?

You should apply this medication to your skin as directed by your healthcare provider. The pump mechanism allows for a precise, targeted application. It's suggested to clean and dry the application area before using.

How does this compounded formulation work?

Each active ingredient contributes to the overall effect of the medication. Amitriptyline is a tricyclic antidepressant, Bupivacaine is a local anesthetic, Gabapentin is used to help control certain types of seizures, and Ketoprofen is a nonsteroidal anti-inflammatory drug. Combined, these ingredients aid in the management of pain or discomfort.

Can this medication be used for all types of pain?

It's mainly used for localized or neuropathic pain. As this is a compounded medication, your healthcare provider will decide if it's right for your specific needs.

Is this medication safe for all skin types?

Although the gel is designed to be gentle on the skin, individual reactions may vary. If you notice any skin irritation, inflammation, or other adverse effects, contact your healthcare provider immediately.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's time for your next dose, skip the missed one. Do not apply extra medication to make up for the missed dose.

What are the potential side effects of this medication?

Side effects may include skin irritation, redness, or a rash at the application site. If you experience any severe side effects, such as difficulty breathing or swelling, seek immediate medical attention.

Can I use other medications with this topical gel?

Discuss all medications you're currently taking with your healthcare provider. Certain medications may interact with the active ingredients in this gel, possibly causing adverse effects.

Can I apply this gel to broken or damaged skin?

Avoid applying the gel to broken or damaged skin or open wounds unless specifically instructed by your healthcare provider. This could lead to medication being absorbed more rapidly, potentially causing increased side effects.

How should I store this compound?

Store the compound at room temperature, away from light and moisture. Keep it out of the reach of children.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCl 5%/Bupivacaine HCl 2%/Gabapentin 5%/Ketoprofen 20% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)

Three times daily