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Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% Topical Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Carbamazepine
Ketamine Hydrochloride
Ketoprofen
Lidocaine Hydrochloride

This formulation is a compounded topical gel containing Carbamazepine 5%, Ketamine HCl 2.3%, Ketoprofen 20%, and Lidocaine HCl 10%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Carbamazepine component is an anticonvulsant and mood stabilizer, often used in the treatment of epilepsy and bipolar disorder. Ketamine HCl, a powerful anesthetic, provides rapid relief from pain and depression. Lidocaine HCl, a local anesthetic, provides relief from pain and discomfort by numbing the skin and surrounding area.

Together, these ingredients create a potent formulation designed to treat a variety of disease states, including neuropathic pain, post-herpetic neuralgia, complex regional pain syndrome, and other conditions that cause chronic pain. This topical gel formulation provides targeted relief right where it's needed, minimizing systemic side effects often associated with oral medications.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Carbamazepine
Ketamine Hydrochloride
Ketoprofen
Lidocaine Hydrochloride
Topical Gel
65380c2801693c1cbe63970d

Formula Information

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This formulation is a compounded topical gel containing Carbamazepine 5%, Ketamine HCl 2.3%, Ketoprofen 20%, and Lidocaine HCl 10%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Carbamazepine is an anticonvulsant and mood stabilizer, often used in the treatment of epilepsy and bipolar disorder. In this formulation, it is used for its analgesic properties to help manage nerve pain. Ketamine HCl is a powerful anesthetic that provides rapid pain relief. It works by blocking the NMDA receptors in the brain which are involved in pain sensation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain by inhibiting the production of prostaglandins, substances in the body that cause inflammation. Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body, providing numbing relief to the area of application.

The topical application allows for targeted treatment, reducing systemic side effects often associated with oral medications.

Patients should apply the gel to the affected area as directed by their healthcare provider. It is important to wash hands before and after application and avoid contact with eyes, mouth, and open wounds. Side effects may include skin irritation at the application site. If these persist or worsen, contact your healthcare provider immediately.

Prescribers should consider this formulation for patients who have not responded to traditional oral medications or who cannot tolerate them due to side effects. As with all medications, it is important to consider the patient's overall health status, other medications, and potential drug interactions.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This formulation contains Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Carbamazepine is an anticonvulsant and mood stabilizer. It can interact with a wide range of medications, including other anticonvulsants, certain antidepressants, anticoagulants, and some antifungal medications. These interactions can lead to changes in the effectiveness of either medication, or increase the risk of side effects.

Ketamine HCl is a powerful anesthetic and analgesic. It can interact with other central nervous system depressants, including alcohol, benzodiazepines, and opioids. These interactions can lead to an increased risk of respiratory depression, sedation, and potentially, overdose.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It can interact with other NSAIDs, corticosteroids, anticoagulants, and certain blood pressure medications. These interactions can increase the risk of gastrointestinal bleeding and ulcers, and may affect kidney function.

Lidocaine HCl is a local anesthetic. It can interact with other local anesthetics and certain heart medications. These interactions can lead to an increased risk of serious heart problems, including irregular heartbeat.

This formulation is designed to be applied topically, which can reduce the risk of systemic drug interactions. However, it's still important to consider potential interactions, especially in patients who are using other medications or have underlying health conditions. The combined use of these medications can be beneficial for treating certain conditions, such as neuropathic pain, but should be used with caution.

Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements. Healthcare providers should carefully consider the potential for drug interactions when prescribing this medication, and monitor patients closely for any signs of adverse effects.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that you and your patients are using this medication safely and effectively.

How Does it Work

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This formulation is a combination of four active ingredients: Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl, each playing a unique role in managing various disease states.

Carbamazepine is an anticonvulsant and mood stabilizer. It works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity. In this formulation, it is used to manage nerve-related pain or discomfort.

Ketamine HCl is a potent analgesic that works by blocking the NMDA receptors in the brain, which are involved in pain signaling. This action helps to reduce the perception of pain, providing relief to the patient.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is used to relieve pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used to relieve pain and discomfort caused by skin irritations, such as sunburn, insect bites, poison ivy, poison oak, poison sumac, and minor cuts, scratches, or burns.

The semisolid formulation dispensed through a pump mechanism allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin, providing targeted treatment for the affected area. This formulation is particularly beneficial for patients who have difficulty swallowing pills or those who prefer a topical treatment option.

It's important to note that while this formulation can provide significant relief for various disease states, it should be used under the guidance of a healthcare provider. Always follow the prescribed dosage and application instructions to ensure the best possible outcome.

If you have any questions about this formulation or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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This compounded formulation of Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% in a topical gel is primarily formulated to help manage pain and inflammation associated with various conditions such as neuropathic pain disorders, arthritis, sports injuries, post-surgical pain, and other musculoskeletal conditions. However, there are additional uses for this formulation, leveraging the unique characteristics of the individual components.

Carbamazepine, primarily used as an anticonvulsant, can also manage certain types of neuropathic pain and psychiatric disorders, offering potential benefit in topical form for skin-related nerve pain conditions and postherpetic neuralgia. Ketamine, typically employed as an anesthetic, has been recognized for neuropathic pain relief in topical formulations. It may also have benefits for treating itching and inflammation associated with certain skin conditions.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), while typically used for pain and inflammation associated with arthritis or injury, may also be beneficial in this formulation for managing dermatologic conditions characterized by inflammation, like psoriasis or eczema. Lidocaine, a local anesthetic, is extensively used in topical formulations for its numbing effect. This can provide symptomatic relief for a myriad of conditions that involve skin irritation or pain such as burns, insect bites, or minor cuts and scrapes.

This Carbamazepine/Ketamine/Ketoprofen/Lidocaine HCl gel formulation could potentially be exploited for other indications, all within the prescribing physician's discretion, based on their assessment of the patient's specific condition and the known pharmacological profiles of the drugs utilized. It offers the convenience of easy application, targeted delivery, and precise dosing, making it a versatile option for various therapeutic needs.

Please note that all uses of compounded medications should be reviewed and approved by a healthcare professional. Patient experience can vary based on individual health status, severity of the condition, other treatments utilized, and individual response to medication. Always consult your healthcare provider before beginning any new treatment.

If you have further questions or need additional information about this formulation or potential uses, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of trained compounding pharmacists is here to provide expert assistance.

Frequently Asked Questions

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What is Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% Topical Gel?

This is a compounded medication in the form of a semisolid gel, designed for topical application on the skin. It combines the therapeutic effects of Carbamazepine, Ketamine HCl, Ketoprofen, and Lidocaine HCl to target specific symptoms and conditions.

How do I apply this medication?

Using the pump mechanism integrated into the bottle, dispense the medication onto the desired area of your skin and smooth it out evenly. Ensure that it is fully absorbed for maximum effectiveness.

What is the consistency of the gel?

The gel has a semi-solid consistency, which makes it easy to apply precisely on the part of the skin where treatment is needed.

Who can use this medication?

This medication should only be used by the person for whom it was prescribed. It should not be shared with others. Additionally, it should only be used for the indication prescribed.

Is this medication safe for everyone?

While this medication is safe for most people, it's important to inform your healthcare provider of all over-the-counter and prescription medications you're currently taking, as well as any allergies or medical conditions. Your provider will assess whether this treatment is safe for you.

What are the possible side effects?

While not everyone will experience side effects, common ones noted with these active ingredients may include mild skin irritation, redness or itching. If you experience severe side effects or prolonged discomfort, please seek medical attention immediately.

Does this medication get absorbed into the body?

Yes, the active ingredients in the gel get absorbed through the skin into the body to provide targeted treatment. Ensure that it is fully absorbed and do not wash or wipe off immediately after application.

What is the role of each active ingredient in the formulation?

Each ingredient plays a significant role. Carbamazepine is used to control certain types of seizures and relieve certain types of nerve pain. Ketamine HCl provides pain relief. Ketoprofen is a type of non-steroidal anti-inflammatory drug (NSAID) used to treat aches and pains. Lidocaine HCl is a local anesthetic, which helps to numb the treatment area.

Can I stop using the medication once I feel better?

No, you should complete the prescribed course of treatment even if you start to feel better. Stopping the medication prematurely may return your symptoms or cause a relapse of your condition.

Can I use this gel with other topicals?

It's important to consult with your healthcare provider before using other topical treatments with this gel. Mixing medications may affect how well they work or increase the risk of side effects.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Carbamazepine 5%/Ketamine HCl 2.3%/Ketoprofen 20%/Lidocaine HCl 10% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)