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This formulation is a combination of Clonidine HCl 0.2%, Doxepin HCl 5.65%, Ketamine HCl 5.75%, Ketoprofen 10%, and Lidocaine 5% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.
The formulation is used to treat a variety of disease states. Clonidine HCl is an alpha-2 adrenergic agonist that is used for pain management and hypertension. Doxepin HCl is a tricyclic antidepressant that can help with anxiety and depression. Ketamine HCl is a NMDA receptor antagonist used for its analgesic and anesthetic properties. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for its anti-inflammatory and analgesic effects, particularly in the treatment of arthritis. Lidocaine is a local anesthetic used for numbing the skin and relieving pain or discomfort.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This formulation is a compounded transdermal gel containing Clonidine HCl 0.2%, Doxepin HCl 5.65%, Ketamine HCl 5.75%, Ketoprofen 10%, and Lidocaine 5%. It is a semisolid formulation that is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency of the formulation ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.
Clonidine HCl is an alpha-2 adrenergic agonist that is commonly used to treat high blood pressure. In this formulation, it is used for its potential analgesic properties and its ability to reduce certain types of neuropathic pain. Doxepin HCl is a tricyclic antidepressant that has been shown to have significant analgesic properties, particularly for neuropathic pain. It also has sedative effects, which can be beneficial for patients with sleep disturbances related to their pain condition.
Ketamine HCl is a powerful anesthetic that is used in this formulation for its potent analgesic properties. It works by blocking the NMDA receptor, which plays a key role in the transmission of pain signals in the nervous system. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain. Lidocaine is a local anesthetic that works by blocking nerve signals in your body and is used to reduce pain or discomfort caused by skin irritations.
This formulation is designed to provide targeted relief from pain and inflammation, making it potentially beneficial for a variety of disease states. These may include conditions characterized by chronic pain, such as fibromyalgia, neuropathic pain, and certain types of arthritis. It may also be beneficial for acute pain conditions, such as post-surgical pain or injury-related pain. As with any medication, it is important to use this formulation under the guidance of a healthcare provider, who can monitor for potential side effects and adjust the treatment plan as necessary.
If you have any questions about this formulation, please do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists at Bayview Pharmacy is always here to help.
This formulation contains a combination of Clonidine HCl, Doxepin HCl, Ketamine HCl, Ketoprofen, and Lidocaine, all of which can interact with other medications. Therefore, it is crucial to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
Clonidine HCl can interact with beta-blockers, calcium channel blockers, and digitalis. Concurrent use of these medications can lead to bradycardia and hypotension. Clonidine HCl can also interact with tricyclic antidepressants, potentially reducing its hypotensive effect. Doxepin HCl can interact with monoamine oxidase inhibitors (MAOIs), leading to serious side effects such as high fever, muscle rigidity, and seizures. It can also interact with selective serotonin reuptake inhibitors (SSRIs), leading to an increased risk of serotonin syndrome.
Ketamine HCl can interact with central nervous system (CNS) depressants, including alcohol, benzodiazepines, and opioids, leading to increased sedation and potentially respiratory depression. Concurrent use of Ketamine HCl and medications that affect liver enzymes, particularly cytochrome P450 3A4 enzymes, can alter the metabolism of Ketamine HCl, affecting its efficacy and safety. Ketoprofen can interact with anticoagulants, antiplatelet drugs, and corticosteroids, increasing the risk of gastrointestinal bleeding. It can also interact with angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and diuretics, potentially reducing their efficacy.
Lidocaine can interact with antiarrhythmic drugs, potentially leading to additive cardiac effects. It can also interact with local anesthetics and CNS depressants, potentially increasing the risk of CNS and cardiovascular toxicity. This formulation is a semisolid gel designed for transdermal application, which can alter the absorption and distribution of these medications, potentially affecting their interactions.
This formulation is used to treat various disease states. Clonidine HCl is an alpha-2 adrenergic agonist used to treat hypertension and severe pain. Doxepin HCl is a tricyclic antidepressant used to treat depression and anxiety. Ketamine HCl is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used to treat severe pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. Lidocaine is a local anesthetic used to treat pain and discomfort from certain skin conditions.
If you have any questions about this formulation or its potential interactions, please do not hesitate to reach out to us. We are here to help ensure the safe and appropriate use of your medications.
This formulation is a combination of five active ingredients: Clonidine HCl, Doxepin HCl, Ketamine HCl, Ketoprofen, and Lidocaine, all of which work together to provide relief from various disease states. The formulation is designed to be applied topically, directly to the skin, where it is absorbed into the body to exert its effects.
Clonidine HCl is a medication that is primarily used to treat high blood pressure, but in this formulation, it is used for its pain-relieving properties. It works by stimulating alpha-2 adrenergic receptors in the brain, which helps to reduce nerve signal transmission and thus decrease pain sensation.
Doxepin HCl is a tricyclic antidepressant that is used in this formulation for its ability to help manage chronic pain, particularly neuropathic pain. It works by increasing the concentrations of certain chemicals in the brain that help regulate mood and pain perception.
Ketamine HCl is a powerful anesthetic that is used in this formulation for its ability to provide rapid pain relief. It works by blocking the NMDA receptors in the brain and spinal cord, which play a key role in transmitting pain signals. By blocking these receptors, Ketamine HCl can effectively reduce the perception of pain.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this formulation for its ability to reduce inflammation and relieve pain. It works by inhibiting the production of prostaglandins, chemicals in the body that cause inflammation and increase pain sensation.
Lidocaine is a local anesthetic that is used in this formulation for its ability to numb the skin and underlying tissues, providing immediate pain relief. It works by blocking sodium channels in the nerve cells, preventing the transmission of nerve signals that carry pain sensations.
The transdermal gel formulation allows for targeted application and absorption of these active ingredients. The gel is easily applied to the skin and absorbed into the body, providing localized relief from pain and inflammation. The pump mechanism allows for precise dosing and easy application.
If you have any questions about this formulation or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.
This unique, topical formulation combines the properties of Clonidine HCl, Doxepin HCl, Ketamine HCl, Ketoprofen, and Lidocaine in a gel base to potentiate their synergistic effects on pain and inflammation. Beyond the standard uses, this compound formulation has applications in various other disease states and conditions as well. For instance, it might be used for complicated regional pain syndrome (CRPS) or other neuropathic pain conditions due to its neurological acting compounds. Clonidine, Doxepin, and Ketamine possess analgesic properties on neuropathic pain sites, making the formulation a potential choice for handling these challenging conditions.
Because the gel is applied topically, it can also be used to treat localized inflammatory conditions like dermatitis or psoriasis, thanks to the anti-inflammatory properties of Doxepin and Ketoprofen. Lidocaine, as a local anaesthetic, can provide relief from the constant itch and discomfort associated with these dermatological conditions. Furthermore, the gel could be considered in treating areas of localized musculoskeletal pain, like in arthritis, back pain or sport-related injuries due to the inclusion of Ketoprofen, a potent non-steroidal anti-inflammatory drug.
While the formulation includes agents with anxiolytic (Clonidine, Doxepin) and anaesthetic (Ketamine, Lidocaine) properties, the transdermal route may not provide sufficient systemic absorption for treating states like anxiety or for surgical anaesthesia. The formulation cannot substitute the oral or parenteral routes when systemic action is required.
Lastly, patients using this formulation should always be informed that the gel is intended for external use only and that accidental ingestion could lead to adverse effects, including drowsiness or more serious cardiovascular effects associated with the active ingredients. If you have any questions about the many potential applications of this compound medication, please don't hesitate to reach out to us at Bayview Pharmacy. We would be more than happy to assist.
This compounded formulation provides targeted treatment by delivering active ingredients directly through the skin. Components in this gel are commonly used to relieve pain and inflammation at specific areas of the body. Though the specific uses might vary, such gels are primarily employed in pain management.
It is a semisolid formulation that is dispensed through a pump mechanism which makes application easy and precise. The gel should be spread thinly and evenly over the area of skin according to the specified dosage or as prescribed by medical professionals.
Each active ingredient in the formulation serves a specific purpose. Clonidine HCl is known as a central alpha agonist that relieves nerve pain. Doxepin HCl works as a tricyclic antidepressant to relieve itching or hives. Ketamine HCl is an anesthetic, Ketoprofen is an anti-inflammatory drug, and Lidocaine is a local anesthetic.
While it's essential to seek a healthcare professional’s advice for each unique case, this gel is typically used to manage pain and inflammation conditions. It can also relieve other symptoms associated with specific skin conditions.
Yes, it is quite common for the formulation to leave a slight residue due to its semisolid consistency. It is imperative not to wash the area immediately after application, allowing ample time for the skin to fully absorb the active ingredients.
The pump mechanism allows for better control over the amount of gel being dispensed, which reduces waste and ensures accurate dosing each time the product is used. This in turn promotes consistent and optimal therapeutic outcomes.
Like any medication, potential side effects can occur, such as skin irritation at the application site. If you develop any sort of allergic response or if the condition worsens even after application of the gel, consult with your healthcare provider immediately.
Onset of relief typically depends on individual factors such as severity of the symptom and its location. However, many users often report some degree of relief within a few hours of application. Regular application as guided by the healthcare provider will usually lead to long-term symptom relief.
The gel should only be applied to the area indicated, avoided on broken, damaged or inflamed skin, and should definitely not come in contact with mucous membranes, eyes, or internally. If you're unsure, always consult a healthcare professional.
While generally safe, it's crucial to inform your healthcare provider about all pre-existing conditions, treatments, and current medications to avoid any harmful interactions. A physician's advice should always be sought before starting or stopping any medication.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
