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Cyclobenzaprine 5%/Ketoprofen 10%/Lidocaine 5% Transdermal Gel

FDA-approved generic
Dose form
Topical Gel
Active ingredients
Ketoprofen
Cyclobenzaprine Hydrochloride
Lidocaine Hydrochloride

This formulation is a combination of Cyclobenzaprine 5%, Ketoprofen 10%, and Lidocaine 5% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Cyclobenzaprine component is a muscle relaxant that works by blocking nerve impulses to relieve muscle spasms. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, swelling, and inflammation. Lidocaine is a local anesthetic that causes temporary numbness in the area where it is applied, providing relief from pain and discomfort.

This formulation is commonly used to treat various disease states including muscle spasms, inflammation, and localized pain. The transdermal delivery allows for direct application to the affected area, providing targeted relief while minimizing systemic side effects.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Ketoprofen
Cyclobenzaprine Hydrochloride
Lidocaine Hydrochloride
Topical Gel
653f6b3a2583514609bf8c5c
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation combines Cyclobenzaprine, Ketoprofen, and Lidocaine in a transdermal gel, which is a semisolid formulation dispensed through a pump mechanism. This allows for easy and precise application on the skin, ensuring targeted treatment or absorption of the active ingredients. The gel-like consistency of the formulation ensures that it adheres well to the skin, providing a sustained release of the active ingredients.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is commonly used to treat muscle spasms and pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It is used to treat mild to moderate pain, or inflammation caused by arthritis. Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. It is used to relieve pain and discomfort from various conditions such as skin irritations and minor burns.

Together, these three active ingredients provide a comprehensive approach to pain management. The Cyclobenzaprine relaxes the muscles, the Ketoprofen reduces inflammation, and the Lidocaine provides immediate, localized pain relief.

It's important to note that this formulation is intended for topical use only and should not be ingested or applied to open wounds or damaged skin. As with any medication, it's crucial to use this formulation as directed by a healthcare professional. Side effects may include skin irritation at the application site, and if these persist or worsen, it's important to contact your healthcare provider.

If you have any questions about this formulation, or if you're a prescriber wanting to use this formulation for your patients, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This formulation contains three active ingredients: Cyclobenzaprine, Ketoprofen, and Lidocaine. Each of these ingredients can interact with other medications, potentially altering their effects or increasing the risk of adverse reactions.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. It can interact with monoamine oxidase inhibitors (MAOIs), increasing the risk of serious side effects such as high fever, severe headache, stiff muscles, and confusion. It can also interact with other central nervous system depressants, including alcohol, antihistamines, sedatives, and narcotics, potentially leading to increased sedation and respiratory depression.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It can interact with blood thinners, such as warfarin, increasing the risk of bleeding. It can also interact with other NSAIDs, corticosteroids, and alcohol, increasing the risk of gastrointestinal bleeding. Additionally, it can interact with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or diuretics, potentially reducing their effectiveness.

Lidocaine is a local anesthetic that works by blocking nerve signals in your body. It can interact with other local anesthetics, potentially leading to increased systemic absorption and toxicity. It can also interact with antiarrhythmic drugs, such as mexiletine and tocainide, potentially altering their effects.

This formulation is designed to treat a variety of disease states. Cyclobenzaprine can help to relieve muscle spasms associated with acute musculoskeletal conditions. Ketoprofen can help to reduce pain and inflammation associated with conditions such as arthritis, bursitis, and tendonitis. Lidocaine can help to provide local anesthesia, relieving pain and discomfort associated with conditions such as postherpetic neuralgia or other types of nerve pain.

It's important to inform your healthcare provider of all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements, to avoid potential drug interactions. If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists, and we are here to help.

How Does it Work

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The Cyclobenzaprine 5%/Ketoprofen 10%/Lidocaine 5% Transdermal Gel is a unique formulation that combines the therapeutic benefits of three active ingredients. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed directly into the targeted area, providing localized relief.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. When applied topically in a gel form, cyclobenzaprine can provide targeted relief to the affected area.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis. In this formulation, ketoprofen is absorbed through the skin directly into the affected area, providing localized anti-inflammatory and analgesic effects.

Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. It does this by blocking the nerve signals in your body. When applied topically, lidocaine can provide rapid, localized pain relief.

Together, these three active ingredients work synergistically to provide relief from various disease states. The muscle relaxant properties of cyclobenzaprine, the anti-inflammatory and analgesic effects of ketoprofen, and the anesthetic properties of lidocaine can effectively treat conditions such as muscle spasms, arthritis, and other sources of pain and inflammation. The transdermal gel formulation allows for targeted treatment, reducing the potential for systemic side effects and providing rapid relief at the site of application.

If you have any questions about this formulation, or if you would like more information on how it can be used to treat specific conditions, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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While primarily prescribed for management of pain and inflammation associated with conditions like arthritis, sprains, and strains, the cyclobenzaprine 5%/ketoprofen 10%/lidocaine 5% transdermal gel is remarkably versatile. This formulation can serve other important roles in patient care due to its unique composition of active ingredients. Cyclobenzaprine, a muscle relaxant, can be used to relieve muscle spasms resulting from injuries such as sprains and strains. On the other hand, lidocaine, a local anesthetic, can be beneficial in alleviating nerve pain including post-shingles neuralgia. Further, it may provide symptomatic relief in certain skin conditions associated with pain and itch, such as bug bites, minor burns, or sunburns.

In addition to these, the anti-inflammatory component, ketoprofen, may help reduce inflammation and associated pain in a multitude of conditions including gouty arthritis, bursitis, tendinitis, and may even show therapeutic effects in soft tissue injuries. It is important to note that while this gel provides localized therapy, it isn't suitable for open wounds or broken skin. Lastly, remember that while this formulation can address symptomatic relief, it does not treat the underlying cause of the medical condition hence should not replace necessary medical intervention.

Utilization of this formulation is patient specific and largely depends on the clinical scenario and the prescriber’s judgment. In all cases, monitoring should be maintained by the healthcare provider, reviewing the patient’s response, and making necessary adjustments. It should be used under the supervision of a healthcare professional and potential side-effects or allergy manifestations should be reported immediately.

So, while the cyclobenzaprine 5%/ketoprofen 10%/lidocaine 5% transdermal gel offers robust therapeutic properties, it is always essential to use it under proper medical guidance. It's also key to ensure its use is appropriate for the specific health needs of the patient. Should you have any other questions or require further information about this, or any formulation, please don't hesitate to reach out to us. As a team of experienced, compounding pharmacists, we're here to support you, clarifying any doubts and providing comprehensive advice to both prescribers and patients.

Frequently Asked Questions

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What is the Cyclobenzaprine 5%/Ketoprofen 10%/Lidocaine 5% Transdermal Gel?

This is a compounded medication that combines Cyclobenzaprine, Ketoprofen, and Lidocaine in a 5%/10%/5% concentration, respectively. It is formulated into a gel that is dispensed through a pump to easily apply to the skin for targeted treatment or absorption.

How does this medication work?

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses that you perceive as pain. Ketoprofen is a nonsteroidal anti-inflammatory drug that reduces substances in the body that cause inflammation. Lidocaine is a local anesthetic that works by causing temporary numbness or loss of sensation in the area of your body where you apply the cream. The combination of these three drugs helps manage pain and inflammation.

How do I use the Cyclobenzaprine 5%/ Ketoprofen 10%/ Lidocaine 5% Transdermal Gel?

Use the pump to dispense an appropriate amount of medication and apply it to the skin area in pain. Follow the exact dosage instructions provided by your healthcare provider. Wash your hands thoroughly after applying unless the treated skin part is your hand.

Can I apply the gel to any part of the body?

You should only apply the gel to the area of discomfort unless otherwise directed by your doctor. Avoid application to open wounds, burns, or the eyes.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Am I supposed to feel immediate relief after application?

You may not feel immediate relief after the first few applications. The reaction to the medication varies among individuals. Keep using the gel as directed and let your healthcare provider know if your condition does not improve or if it worsens.

Can this gel cause any allergic reactions?

Although rare, serious allergic reactions may occur. Stop using the medication and seek immediate medical attention if you notice symptoms like rash, itching/swelling (particularly of the face/tongue/throat), severe dizziness, or trouble breathing.

How should I store the gel?

The gel should be stored at room temperature, away from heat and light. Keep the container tightly closed when not in use.

Can this gel be used in conjunction with other medications?

Always inform your doctor about any other medications you are currently using to prevent any drug interactions. Do not mix the gel with other topical creams without consulting your healthcare provider.

Is this gel safe for pregnant or nursing mothers?

If you are pregnant, planning to get pregnant, or breastfeeding, inform your doctor before using the gel. The effects of the medications in this gel on the fetus or nursing baby are unknown.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Cyclobenzaprine 5%/Ketoprofen 10%/Lidocaine 5% Transdermal Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)

Three times daily