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Cyclobenzaprine Hydrochloride is a muscle relaxant commonly used to alleviate muscle spasms associated with acute musculoskeletal conditions.
Cyclobenzaprine hydrochloride is a centrally acting skeletal muscle relaxant used as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.[1][2] It acts primarily within the central nervous system at the brain stem, and it does not act directly on skeletal muscle or at the neuromuscular junction.[1][2] The FDA label states it should be used only for short periods, up to 2 or 3 weeks.[2]
Bayview compounds cyclobenzaprine hydrochloride on a prescriber's order, including when a dosage or dosage form not available in commercially manufactured products is prescribed.
Prescribers should be aware of the potential side effects of cyclobenzaprine hydrochloride, the most common of which are drowsiness, dry mouth, and dizziness.[2] It may impair the mental or physical abilities needed for hazardous tasks such as operating machinery or driving.[2] Cyclobenzaprine is contraindicated during the acute recovery phase of myocardial infarction and in patients with arrhythmias, heart block or conduction disturbances, congestive heart failure, or hyperthyroidism, and like tricyclic antidepressants it may cause arrhythmias and tachycardia.[1][2]
When considering cyclobenzaprine hydrochloride, it is important to review concurrent medications. It is contraindicated with MAO inhibitors or within 14 days of stopping them, and serotonin syndrome has been reported when it is combined with other serotonergic drugs.[2] It is metabolized in the liver by cytochrome P450 enzymes, including CYP3A4, CYP1A2, and CYP2D6.[1] It should be used with caution in mild hepatic impairment and is not recommended in moderate to severe hepatic impairment.[1][2]
Compounded at Bayview
Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.
For prescribers
Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.
Cyclobenzaprine, the muscle relaxant sold as a tablet, prepared by Bayview as a topical gel (or a cream on request) in strengths from 0.5% to 5%, to a prescriber's order, so it can be rubbed into the painful muscle instead of swallowed. No cyclobenzaprine gel, cream, liquid, or troche is manufactured. The compounded forms are not FDA-approved, their use is off-label, and a prescription is required.
Anyone who has taken an MAOI in the past 14 days, is recovering from a heart attack, has an irregular heartbeat, heart block, or heart failure, has an overactive thyroid, or is allergic to it. Talk with your prescriber first if you have liver disease, glaucoma, or trouble urinating, take an antidepressant, tramadol, or other sedating medicines, are 65 or older, or are pregnant or breastfeeding. It is not established as safe in children under 15.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
