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The Ketamine 5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a specialized semisolid formulation designed for targeted application on the skin. This unique compound combines the analgesic and anesthetic properties of ketamine and lidocaine with the anti-inflammatory effects of ketoprofen. The gel is dispensed through a pump mechanism, which ensures easy and precise dosing. The consistency of the gel allows for optimal skin contact and potential absorption of the active ingredients.
This formulation is primarily used in the management of neuropathic pain and chronic pain conditions. It may also be beneficial for patients experiencing localized pain and inflammation, such as in certain musculoskeletal disorders. The combination of active ingredients works synergistically to provide pain relief and reduce inflammation directly at the site of application, offering an alternative or adjunct to systemic medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Our compounded Ketamine 5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a specialized medication designed for targeted pain relief. This unique formulation combines the analgesic and anesthetic properties of three active ingredients to provide a synergistic effect for managing pain. Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, it may help in reducing the sensation of pain by blocking NMDA receptors, which are involved in pain transmission.
Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the enzyme cyclooxygenase, which is involved in the production of prostaglandins, substances that mediate inflammation and pain. By reducing the levels of prostaglandins, ketoprofen can help alleviate inflammation and associated pain. Lidocaine HCl, a local anesthetic, provides immediate relief by blocking sodium channels and thus the transmission of pain signals along the nerves.
The combination of these three agents in a 5%/10%/5% concentration, respectively, in a gel base allows for direct application to the affected area, offering localized relief without the systemic side effects often associated with oral medications. The semisolid formulation is designed to be dispensed through a pump mechanism, which ensures easy and precise dosing. The gel consistency allows for quick absorption through the skin and can be particularly beneficial for patients who have difficulty swallowing pills or who prefer a non-invasive treatment option.
This topical gel is commonly used for the treatment of localized musculoskeletal pain, neuropathic pain, and inflammatory conditions. It may be particularly useful for patients suffering from conditions such as arthritis, tendonitis, bursitis, or nerve-related pain such as postherpetic neuralgia. The combination of anesthetic and anti-inflammatory effects can provide significant pain relief and improve the quality of life for patients dealing with chronic pain conditions.
As with any compounded medication, it is important for patients and prescribers to be aware of the potential for side effects and interactions with other medications. The pharmacists at Bayview Pharmacy are available to discuss the benefits and considerations of this topical gel formulation, ensuring that it is appropriate for the patient's specific condition and medical history. We encourage open communication and are here to answer any questions or concerns regarding this or any other compounded medication. Please reach out to us for personalized support and guidance.
The topical gel formulation containing Ketamine 5%, Ketoprofen 10%, and Lidocaine HCl 5% is designed for localized application and is intended to provide analgesia and reduce inflammation in the area of application. However, it is important to consider potential drug interactions when using this compound, especially if the patient is taking other medications systemically or applying other topical agents.
Ketamine, when used topically, is generally considered to have a low risk of systemic absorption and thus a low risk of systemic drug interactions. However, caution should be exercised if the patient is taking CNS depressants or psychoactive drugs, as there may be an additive effect on sedation and CNS depression. Additionally, if the patient is prescribed other NMDA antagonists, the risk of CNS side effects may be increased.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with other NSAIDs, increasing the risk of gastrointestinal ulceration or bleeding. Although the systemic absorption of ketoprofen from topical application is lower than from oral administration, it is still important to consider the total NSAID load, especially in patients taking oral NSAIDs or anticoagulants. Concomitant use with other medications that affect renal function, such as ACE inhibitors or diuretics, may also require monitoring.
Lidocaine is a local anesthetic and, when applied topically, has a low risk of systemic absorption. However, if used concomitantly with other local anesthetics or medications that affect cardiac conduction, there may be an increased risk of adverse cardiac effects. Caution is advised if the patient is on antiarrhythmic drugs, as there may be additive effects on the heart.
It is also important to consider the potential for skin irritation or allergic reactions when using this compound, especially if the patient has a history of sensitivity to any of the ingredients or similar medications. The use of other topical preparations on the same area of skin should be discussed with a healthcare provider to avoid potential interactions or enhanced absorption through compromised skin integrity.
This compounded formulation is used to treat localized pain, inflammation, and neuropathic conditions. The combination of an NMDA antagonist (ketamine), an NSAID (ketoprofen), and a local anesthetic (lidocaine) provides a multimodal approach to pain management, which can be beneficial in conditions such as arthritis, tendonitis, neuropathic pain, and other musculoskeletal disorders. The precise application through a pump mechanism allows for consistent dosing and targeted therapy, minimizing systemic exposure and potential side effects.
If you have any questions or require further information regarding the use of this compounded formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. We are here to ensure the safe and appropriate use of this medication for your patients.
The Ketamine 5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a compounded medication designed to deliver a combination of active ingredients directly to the site of pain or inflammation through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied and facilitates the absorption of the active ingredients into the affected area.
Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, ketamine works by blocking N-methyl-D-aspartate (NMDA) receptors in the nervous system, which are involved in the transmission of pain signals. By inhibiting these receptors, ketamine can help reduce the sensation of pain.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing their production, ketoprofen effectively decreases inflammation and pain in the tissues where the gel is applied.
Lidocaine HCl is a local anesthetic that provides rapid numbing effects to the area of application. It works by blocking sodium channels on the neuronal cell membrane, which prevents the initiation and conduction of nerve impulses. This action results in a temporary loss of sensation in the area, providing relief from pain.
When combined, these three ingredients offer a multimodal approach to pain management. The gel is particularly useful for conditions that involve inflammation and pain, such as musculoskeletal injuries, neuropathic pain, and certain types of arthritis. By applying the gel topically, patients can achieve localized relief with potentially fewer systemic side effects compared to oral medications.
It is important for both patients and prescribers to understand that while this topical gel can provide significant relief, it should be used as directed by a healthcare professional. The compounding pharmacists at Bayview Pharmacy can provide guidance on the appropriate use of this medication, including the amount to apply and the frequency of application. If you have any questions or require further information about this formulation and its use in treating specific disease states, please reach out to us.
This is a compounded medication that combines the active ingredients ketamine, ketoprofen, and lidocaine HCl in a topical gel form. The formulation is designed to provide pain relief by direct application to the skin in areas experiencing pain or inflammation.
Apply a measured dose using the pump mechanism provided with the product. Use enough gel to cover the painful area completely, but avoid applying too much. The pump provides a specific amount with each dispersion to help ensure you use the correct dose.
The frequency of application will depend on the instructions given by your healthcare provider. Always follow the dosing guidelines provided specifically for you. Do not apply more frequently than recommended as this could increase the risk of side effects.
This gel is intended for external use only and should be applied to the area of pain or inflammation as directed by your healthcare provider. Avoid sensitive areas such as the eyes, mouth, and mucous membranes. If you are unsure about where to apply the gel, consult your healthcare provider for guidance.
Avoid covering the treated areas with tight bandages or occlusive dressings unless advised by your healthcare provider. Also, avoid using heating pads or other heat sources on the treated area as these can increase absorption of the medication and the potential for side effects.
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for a missed dose.
Because this is a topical formulation, it may have less interaction with other medications than oral forms might. However, always inform your healthcare provider about all the medications and supplements you are currently taking to rule out potential interactions.
As with any medication, side effects are possible. Common side effects could include skin irritation or rash at the application site. If you experience severe or worrisome symptoms, or if the side effects do not go away, contact your healthcare provider immediately.
Store the gel at room temperature, away from heat and direct light. Do not freeze the medication, and keep the container tightly closed. Keep this and all medications out of reach of children and pets.
If someone ingests this medication, seek immediate medical attention or call a poison control center. It is important to keep the medication out of reach to prevent accidental ingestion, especially in children.
Water or moisture may affect the gel if you swim or shower shortly after application. It is generally recommended to wait a significant amount of time—your healthcare provider can give specific advice—after applying the gel before getting the treated area wet.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
