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The Ketamine HCl 5%/Ketoprofen 10%/Lidocaine 10% Transdermal Gel is a specialized medication compounded to manage pain associated with various disease states. This semisolid formulation is designed for transdermal delivery of active pharmaceutical ingredients and is dispensed through a pump mechanism, which allows for easy and precise application to the skin. The gel-like consistency ensures that the medication is spread evenly and absorbed effectively at the site of pain.
The combination of Ketamine HCl, an NMDA receptor antagonist, with Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), and Lidocaine, a local anesthetic, provides a multimodal approach to pain management. This formulation is commonly used to treat neuropathic pain, chronic pain syndromes, and inflammatory conditions. By delivering the medication directly to the affected area, this transdermal gel minimizes systemic exposure and potential side effects, offering targeted relief for patients suffering from these debilitating disease states.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Ketamine HCl 5%/Ketoprofen 10%/Lidocaine 10% Transdermal Gel is a compounded medication designed for topical application. This semisolid formulation is dispensed through a pump mechanism, which ensures easy and precise dosing. The gel base allows for the active ingredients to be absorbed through the skin, targeting localized areas for therapeutic effects. The combination of active ingredients in this formulation works synergistically to provide analgesic and anti-inflammatory effects.
Ketamine HCl, a N-methyl-D-aspartate (NMDA) receptor antagonist, is utilized in this formulation for its analgesic properties, particularly in neuropathic pain. By blocking NMDA receptors, ketamine can help reduce the sensation of pain. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), contributes to the formulation by providing anti-inflammatory and analgesic effects, making it beneficial for conditions involving inflammation and pain such as arthritis or musculoskeletal injuries. Lidocaine, a local anesthetic, offers immediate relief from pain by blocking sodium channels and numbing the affected area. This can be particularly useful for patients experiencing sharp, localized pain or for initiating therapy while waiting for the other components to take effect.
This transdermal gel is particularly suited for patients who require targeted pain relief or who may not tolerate oral medications well due to systemic side effects or gastrointestinal issues. The transdermal route of administration provides the advantage of delivering medication directly to the site of pain, potentially reducing the risk of systemic side effects. This formulation is commonly used in the management of neuropathic pain, localized inflammatory conditions, and certain musculoskeletal disorders.
It is important for both patients and prescribers to understand that this is a specialized medication prepared in a compounding pharmacy. The concentration of active ingredients has been carefully selected to maximize therapeutic effects while minimizing potential adverse effects. Patients should use this medication as directed by their healthcare provider and report any adverse reactions or concerns immediately. As with any compounded medication, it is essential to use this formulation under the guidance and prescription of a healthcare professional familiar with the patient's medical history and current condition.
For further information or questions regarding the Ketamine HCl 5%/Ketoprofen 10%/Lidocaine 10% Transdermal Gel, or to discuss its suitability for specific patient needs, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is committed to providing high-quality, individualized care to our patients and supporting healthcare providers in their treatment plans.
The transdermal gel formulation containing Ketamine HCl 5%, Ketoprofen 10%, and Lidocaine 10% is designed for topical application and may offer localized relief from pain and inflammation. Ketamine is an NMDA receptor antagonist that can provide analgesia and may have anti-inflammatory effects. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes COX-1 and COX-2, which are involved in prostaglandin synthesis, leading to reduced inflammation and pain. Lidocaine is a local anesthetic that blocks sodium channels, thereby providing a numbing effect and further contributing to pain relief.
When considering drug interactions, it is important to note that while the systemic absorption of these medications in a transdermal formulation is lower than oral or parenteral routes, interactions can still occur. Ketamine may interact with CNS depressants, such as benzodiazepines, opioids, and alcohol, potentially enhancing sedative effects. Caution is advised when using this medication concurrently with other CNS depressants. Ketoprofen, as an NSAID, may increase the risk of bleeding when combined with anticoagulants like warfarin or antiplatelet agents such as aspirin. It may also interact with other NSAIDs, leading to an increased risk of gastrointestinal ulcers or bleeding, and with ACE inhibitors or angiotensin receptor blockers, potentially diminishing their antihypertensive effects. Lidocaine, although less likely to interact due to its local action, may still pose a risk when used with other local anesthetics or medications that affect cardiac conduction, as it can have additive effects on the heart.
Patients should be advised to inform their healthcare providers of all medications they are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Prescribers should carefully consider the patient's medication profile before prescribing this transdermal gel. Monitoring for side effects or signs of systemic absorption, such as dizziness, confusion, gastrointestinal distress, or abnormal bleeding, is recommended. If you have any questions or require further information regarding this formulation and its potential interactions, please reach out to us at Bayview Pharmacy for assistance.
The Ketamine HCl 5%/Ketoprofen 10%/Lidocaine 10% Transdermal Gel is a compounded medication designed to deliver active pharmaceutical ingredients through the skin, directly to the site of pain or inflammation. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied and facilitates the absorption of the active ingredients into the skin.
Ketamine HCl, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this transdermal formulation, Ketamine HCl acts on the N-methyl-D-aspartate (NMDA) receptors in the central nervous system, which play a significant role in pain modulation. By blocking these receptors, ketamine can help reduce central sensitization, which is a condition where the central nervous system amplifies pain signals, leading to heightened sensitivity to pain.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing the production of these chemicals, ketoprofen can help alleviate inflammation and pain at the site of application.
Lidocaine is a local anesthetic that provides rapid pain relief by blocking the sodium channels in the neuronal cell membranes. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing effect and temporary relief from pain. When combined with ketamine and ketoprofen, lidocaine enhances the overall analgesic effect of the gel.
This transdermal gel is particularly useful for treating localized pain conditions such as neuropathic pain, musculoskeletal pain, and certain inflammatory conditions. By delivering the medication directly to the affected area, systemic side effects are minimized, and relief can be targeted more precisely.
Patients and prescribers should note that this is a specially compounded formulation and should be used under the guidance of a healthcare professional. It is important to apply the gel as directed and to the specific area of pain or inflammation to ensure the best therapeutic outcome. If there are any questions or concerns regarding the use of this transdermal gel, or if additional information is needed, please reach out to us at Bayview Pharmacy for assistance.
This is a compounded medication that combines Ketamine HCl, Ketoprofen, and Lidocaine in a transdermal gel form. It is used to deliver these medications through the skin to provide pain relief in a targeted area.
Apply a thin layer of gel to the affected area as directed by your healthcare provider. Use the pump mechanism to dispense the prescribed amount of medication. Spread the gel gently and thoroughly on the skin.
The frequency of application will depend on your specific condition and instructions provided by your healthcare provider. Do not alter the dosing schedule without consulting them first.
No, you should only apply the gel to intact skin. Avoid areas with open wounds, cuts or significant irritation. If you are unsure, please consult your healthcare provider.
As with all medications, there can be side effects. These may include local skin reactions such as redness, itching, or irritation at the application site. Systemic side effects are less common but can occur, so if you experience any unusual symptoms, contact your healthcare provider immediately.
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular application schedule. Do not double the dose to catch up.
Store the gel at room temperature, away from heat and direct light. Do not freeze it, and keep it out of reach of children and pets.
You can cover the area lightly with clothing, but do not bandage or wrap it tightly, which might increase the absorption of the medication. Wait until the gel has dried before putting any clothing over the treated area.
No, applying more gel will not increase your pain relief and can lead to increased side effects. Always use the medication as prescribed by your healthcare provider.
Inform your healthcare provider about all the medications you are currently taking to avoid potential interactions. Some medications may alter the effects of the gel or increase the risk of side effects.
You should only use this medication during pregnancy or while breastfeeding if it has been specifically recommended by your healthcare provider. They will assess the risks and advise you accordingly.
If you suspect an overdose, or if the gel has been ingested, contact your local poison control center or seek emergency medical attention immediately.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Apply topically to affected area(s)
