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Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream

FDA-approved generic
Dose form
Topical Cream
Active ingredients
Cyclobenzaprine Hydrochloride
Ketamine Hydrochloride
Ketoprofen
Menthol

This formulation is a semisolid preparation of Cyclobenzaprine HCl 2%, Ketamine HCl 11.5%, Ketoprofen 15%, and Menthol 3% Topical Cream. It is dispensed in a pump mechanism for convenient and controlled application on the skin. The active ingredients are designed for localized treatment or absorption.

The formulation is used to treat a variety of disease states. Cyclobenzaprine HCl is a muscle relaxant that helps to relieve muscle spasms, while Ketamine HCl is a potent analgesic that provides relief from severe pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body. Menthol provides a cooling sensation and helps to numb the skin, providing additional relief from pain and discomfort.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Cyclobenzaprine Hydrochloride
Ketamine Hydrochloride
Ketoprofen
Menthol
Topical Cream
653edd63621a9b87365383f8

Formula Information

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This formulation is a compounded topical cream containing Cyclobenzaprine HCl 2%, Ketamine HCl 11.5%, Ketoprofen 15%, and Menthol 3%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. This formulation is intended for localized treatment or absorption of active ingredients.

Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is commonly used to treat muscle spasms and to relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Ketamine HCl is a potent analgesic that provides pain relief by blocking the NMDA receptors in the brain which are involved in pain sensation. It is often used in pain management for conditions such as neuropathic pain and fibromyalgia.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is used to treat mild to moderate pain, or inflammation caused by conditions such as arthritis. Menthol is a local anesthetic that provides a cooling sensation and helps to numb the skin, providing further relief from pain and discomfort.

This combination of active ingredients in a topical cream formulation allows for targeted relief at the site of pain or inflammation. The cream is applied directly to the affected area, reducing systemic exposure and potential side effects compared to oral medications. The pump mechanism allows for controlled dosing and easy application.

It's important to note that this is a compounded medication, meaning it is made specifically for you based on a doctor's prescription. It is not a commercially available product and should be used only under the supervision of a healthcare provider. As with any medication, it's important to use this product as directed by your healthcare provider and report any side effects or adverse reactions immediately.

If you have any questions about this formulation, its use, or any other aspect of your medication, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Drug Interactions

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This formulation contains a combination of Cyclobenzaprine HCl, Ketamine HCl, Ketoprofen, and Menthol. Each of these active ingredients can interact with other medications, potentially altering their effects. Therefore, it's crucial to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter products, and herbal supplements.

Cyclobenzaprine HCl, a muscle relaxant, may interact with drugs like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and certain heart medications. Combining these drugs can increase the risk of serious side effects such as serotonin syndrome, irregular heart rhythm, and severe drowsiness. Avoid consuming alcohol as it can enhance these side effects.

Ketamine HCl, an NMDA receptor antagonist, can interact with CNS depressants, opioids, and certain anesthetics. These interactions can lead to an increased risk of severe respiratory depression, profound sedation, and hypotension. It's also important to avoid grapefruit juice while using this medication as it can increase the levels of ketamine in your body, leading to increased side effects.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with anticoagulants, antiplatelet drugs, and other NSAIDs, increasing the risk of bleeding and ulcers. It can also interact with certain blood pressure medications and diuretics, potentially reducing their effectiveness. Avoid alcohol and tobacco while using this medication as they can increase the risk of stomach bleeding.

Menthol, a topical analgesic, generally has fewer interactions. However, it can cause skin irritation when used with other topical products that also irritate the skin. Therefore, it's important to inform your healthcare provider about all the topical products you are currently using.

This formulation is designed to treat various disease states. Cyclobenzaprine HCl helps to relax muscles and reduce muscle spasms, making it useful in conditions like fibromyalgia and muscle injuries. Ketamine HCl provides pain relief, particularly for neuropathic pain conditions. Ketoprofen reduces inflammation and pain, making it beneficial for conditions like arthritis and other inflammatory diseases. Menthol provides a cooling sensation that can help to soothe minor aches and pains.

Remember, this is not a complete list of possible drug interactions. Always consult with your healthcare provider or pharmacist to understand the potential interactions of your medications. If you have any questions or concerns about this formulation, please reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists, ready to assist you with your medication needs.

How Does it Work

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This formulation is a combination of four active ingredients: Cyclobenzaprine HCl, Ketamine HCl, Ketoprofen, and Menthol, each with a unique mechanism of action that contributes to the overall therapeutic effect of the cream. The cream is designed to be applied topically, directly to the skin, where it can be absorbed locally to provide targeted relief.

Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. When applied topically, it can provide localized relief without the systemic side effects often associated with oral administration.

Ketamine HCl is a powerful analgesic that works by blocking the NMDA receptor, a type of glutamate receptor in the brain and spinal cord. This action can effectively reduce pain signals, providing relief from chronic and acute pain. In a topical formulation, Ketamine HCl can provide targeted pain relief directly at the site of application.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is commonly used to relieve pain, swelling, and joint stiffness caused by arthritis. In this topical formulation, Ketoprofen can provide localized anti-inflammatory and analgesic effects, reducing pain and inflammation at the site of application.

Menthol is a natural substance derived from peppermint or other mint oils. It provides a cooling sensation when applied to the skin, which can help to numb pain and reduce inflammation. Menthol also helps to increase blood flow to the area, which can aid in the absorption of the other active ingredients in the cream.

The cream is dispensed in a pump mechanism, which allows for convenient and controlled application. This ensures that the correct dose is applied each time, reducing the risk of side effects and increasing the effectiveness of the treatment.

If you have any questions about this formulation, or if you would like more information on how it can be used to treat specific conditions, please don't hesitate to reach out to us. Our team of knowledgeable compounding pharmacists at Bayview Pharmacy is always here to help.

Other Uses

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This unique compounding formulation of Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream makes it a versatile option beyond the already extensive traditional uses. The combination of these active ingredients offers a multidimensional approach to pain management, which goes beyond typical disease states.

Cyclobenzaprine is typically employed for relief of muscle spasms and associated pain, but its topical administration can also be considered in conditions like fibromyalgia or neck pain. Ketamine HCl, on the other hand, has a broad reach of application. The topical administration helps to avoid the systemic side effects associated with its traditional use. In addition, it may work synergistically with the other compounds to enhance pain control, promote muscle relaxation, and contribute to an overall decline in inflammation.

Ketoprofen, similar to other NSAIDs, is used to relieve pain from various conditions. When compounded in this formulation, it works locally to decrease pain and inflammation in the skin, muscles, or joints close to the skin's surface. Concurrently, menthol provides a cooling sensation, providing immediate comfort and relief from itching, burning, and pain from skin irritations. Moreover, its inclusion helps to promote better absorption of the other compounds into the skin.

Beyond pain management, this formulation might also find a role in athletes and individuals with physically demanding jobs that lead to overexertion of muscles and joints. Under the supervision of a healthcare provider, this topical application might assist in the management of minor sprains, strains, or muscular injuries associated with physical activity.

In conclusion, the Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream offers versatility in its application, contributing to its value in pain management and other potential therapeutic uses. However, optimal use depends on a careful assessment of the patient's condition and needs. Always consult with a healthcare provider before starting or changing your medication regimen. Should you have any questions or concerns about this formulation, please feel free to reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream?

This is a compounded formulation of several active ingredients: Cyclobenzaprine Hydrochloride, Ketamine Hydrochloride, Ketoprofen, and Menthol. It is a semi-solid preparation dispensed with a pump mechanism for convenient application on the skin to deliver localized treatment.

What should I use Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream for?

This cream is used for the localized treatment of several conditions, primarily those related to pain and inflammation. Consult your doctor to know if this is the right treatment option for your medical condition.

How do I properly apply this cream?

The cream is dispensed using a pump mechanism provided with the container. Apply a thin layer of the cream to the affected area as directed by your doctor or pharmacist.

How often should I use this cream?

The frequency of application will depend on your medical condition and your doctor's instructions. Always follow your healthcare provider's guidelines regarding the use of this medication.

What are the active ingredients in this compounded formulation?

This formulation contains Cyclobenzaprine Hydrochloride, Ketamine Hydrochloride, Ketoprofen, and Menthol that work together to provide pain relief and reduce inflammation.

Who should avoid using Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream?

Individuals with known allergies to any of the active ingredients in the cream, or those instructed by their healthcare provider to avoid these medications should refrain from using this cream.

Does this cream have any side effects?

Like with any medication, potential side effects may occur. Some common side effects might include skin irritation, redness or itching at the application site. Always consult your health care provider for medical advice about side effects.

Can I use this cream with other medications?

It is important to provide your health care provider with a list of all the medications you are currently taking, as this cream may interact with other drugs. Your doctor will consider this when prescribing this medication.

Should I use this cream if pregnant or breastfeeding?

If you are pregnant or breastfeeding, inform your health care provider. They will evaluate the potential risks and benefits before advising you on using this medication.

What do I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's nearly time for your next dose, then skip the missed dose. Never apply extra cream to make up for a missed dose.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Cyclobenzaprine HCl 2%/Ketamine HCl 11.5%/Ketoprofen 15%/Menthol 3% Topical Cream
Topical Cream
30 g
controlled

Apply topically to affected area(s)